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23 Cards in this Set
- Front
- Back
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Paracortex swelling
- occurs under what conditions? |
- Extreme response of Cellular Immunity
(i.e. - viral) |
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Paracortex does NOT develop well in what Dz?
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- DiGeorge Syndrome
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MHC I binds what receptors?
MHC II binds what receptors? |
- TCR
- CD8 - TCR - CD4 |
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Which MHC
- mediates Viral immunity - pairs up with Beta-2 microglobulins |
- MHC I
- MHC I |
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Which MHC
- loads Antigens that are mostly Intracellular Peptides @ RER? |
- MHC I
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Which MHC
- loads Antigens following release of an Invariant chain @ acidified Endosome |
- MHC II
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Which MHC
- expressed on all Nucleated cells - expressed ONLY on APCs (BMD) |
- MHC I
- MHC II |
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Natural Killer Cells
- are the only lymphocytes of what immune system - kills by inducing apoptosis of what cells? |
- Innate Immune System
- Viral-infected cells - Tumor cells |
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Natural Killer Cells
- induced to kill under what conditions? |
- Absence of MHC I
- Exposure of NonspecifiK Activation Signal |
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Natural Killer Cells
- NK activity enhanced by what Cytokines? |
- IFN-alpha
- IFN-beta - IL-12 |
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B-cell or T-cells
- Type I Hypersensitivity? - Type II Hypersensitivity? - Type III Hypersensitivity? - Type IV Hypersensitivity? |
- B-cells do I, II, & III
- T-cells do IV |
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Positive Selection
- occurs where? - selects what type of T-cell? |
- Cortex of Thymus
- CD4+/CD8+ T cells |
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Negative Selection
- occurs where? - selects what type of T-cell? |
- Medulla of Thymus
- CD4+ T cell - CD8+ T cell |
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@ the LN
- CD4+ T-cells become what? - CD8+ T-cells become what? |
- Helper T-cells
- Cytotoxic T-cells |
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@ the LN
- Helper T-cells become what? x2 - which one mediates CMI - which one mediates Humoral Immune |
- Th1 (CMI)
- Th2 (Humoral) |
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HELPER T-cells
- Th1 induced by? - Th1 inhibited by? |
- IL-12
- IL-10 (secreted from Th2) |
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HELPER T-cells
- Th2 induced by? - Th2 inhibited by? |
- IL-4
- IFN-gamma (secreted from Th1) |
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HELPER T-cells
- Th1 secretes what cytokines |
- IL-2
- IFN-gamma (inhibits Th2) |
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HELPER T-cells
- Th2 secretes what cytokines |
IL-4
IL-5 IL-6 IL-10 (inhibits Th1) |
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HELPER T-cells
- which one activates Macrophages? |
- Th1
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HELPER T-cells
- which one activates CD8+ T-cells |
- Th1
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HELPER T-cells
- which one helps B-cells make Ab? - which Ab? |
Th2
IgE > IgG |
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HELPER T-cells
- bind to APC receptor MHC II, via what receptor? |
CD4
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