Xxx - Bchm Vii - Lipid Metabolism

Front 1

LIPID METABOLISM

- Two-Thirds (2/3) of cholesterol is esterified by what?

Back 1

- Lecithin-Cholesterol Acyltransferase

(LCAT)

Front 2

LIPID METABOLISM

- Pancreatic Lipase degrades what TG's?

- these TG's are located where?

Back 2

- Dietary TG

- small intestine

Front 3

LIPID METABOLISM

- Lipoprotein Lipase (LPL) degrades what TG's?

- these TG's are located where?

Back 3

- Circulatory TG

- in Chylomicrons & VLDL's

Front 4

LIPID METABOLISM

- Hepatic TG Lipase (HL) degrades what TG's?

- these TG's are located where?

Back 4

- TG's remaining in IDL

Front 5

LIPID METABOLISM

- Hormone-Sensitive Lipase degrades what TG's?

- these TG's are located where?

Back 5

- TG's stored in Adipose

Front 6

LIPID METABOLISM

- Cholesterol Ester Transfer Protein (CETP) mediates what?

Back 6

- Transfer of Cholesterol to other Lipoprotein particles

Front 7

LIPID METABOLISM

- Apolipoprotein A-1 function?

Back 7

(A = A)

- Activates LCAT

Front 8

LIPID METABOLISM

- Apolipoprotein B-100 function?

Back 8

(B=B)

- Binds to LDL receptor & mediates VLDL secretion

Front 9

LIPID METABOLISM

- Apolipoprotein C-II function?

Back 9

(C=C)

- Cofactor for LPL

Front 10

LIPID METABOLISM

- Apolipoprotein B-48 function?

Back 10

- mediates Chylomicron secretion

Front 11

LIPID METABOLISM

- Apolipoprotein E function?

Back 11

(E=E)

- mediates Extra (remnant) Uptake

Front 12

LIPID METABOLISM

- which apolipoprotein mediates Chylomicron secretion?

- which apolipoprotein mediates VLDL secretion?

Back 12

- B-48

- B-100

Front 13

LIPID METABOLISM

- which apolipoprotein is needed for LCAT?

- which apolipoprotein is needed for LDL?

Back 13

A-I

C-II

Front 14

LIPID METABOLISM

- which Lipoprotein carries most of the cholesterol?

Back 14

- LDL

- HDL

Front 15

LIPID METABOLISM

- transports cholesterol from Liver to Tissues?

Back 15

(LDL is Lousy)

- LDL

Front 16

LIPID METABOLISM

- transports cholesterol from peripheral Tissues to Liver?

Back 16

(HDL is Healthy)

- HDL

Front 17

LIPID METABOLISM

- Carries Cholesterol to peripheral tissue

- Carries DIETARY TG to peripheral tissue

- Carries HEPATIC TG to peripheral tissue

Back 17

- LDL

- Chylomicrons

- VLDL

Front 18

LIPID METABOLISM

- can deliver cholesterol to Liver

- can deliver cholesterol to Liver in the form of remnants (mostly depleted of triacylglycerols)

Back 18

- HDL

- Chylomicrons

Front 19

LIPID METABOLISM

- which lipoprotein is secreted by INTESTINAL Epithelial cells?

Back 19

- Chylomicrons

Front 20

LIPID METABOLISM

- which lipoprotein is secreted by the LIVER?

Back 20

- VLDL

Front 21

LIPID METABOLISM

- HDL is secreted from where?

Back 21

- Liver

AND

- Intestine

Front 22

LIPID METABOLISM

- degradation of VLDL forms?

- occurs where?

Back 22

- IDL (in the Liver)

- LDL (in the Peripheral Tissue)

Front 23

LIPID METABOLISM

- formed by LPL modification of VLDL

- where?

Back 23

- LDL

- Peripheral Tissue

Front 24

LIPID METABOLISM

- taken up by Target cells

- via what process?

Back 24

- LDL

- Receptor mediated Endocytosis

Front 25

LIPID METABOLISM

- HDL acts as a repository for what apolipoproteins?

- these apolipoproteins are important for what?

Back 25

- apoC
- apoE

- Chylomicron metabolism
- VLDL metabolism

Front 26

LIPID METABOLISM

- Chylomicron apolipoproteins

Back 26

A-4

B-48

C-2

E

Front 27

LIPID METABOLISM

- VLDL apolipoproteins

Back 27

B-100

C-2

E

Front 28

LIPID METABOLISM

- IDL apolipoproteins

Back 28

B-100

E

Front 29

LIPID METABOLISM

- LDL apolipoproteins

Back 29

B-100