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15 Cards in this Set
- Front
- Back
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What are the contents of single donor platelets?
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100mL of volume, platelets have to be at least 3x10^11 in 90% of tested, plasma (150mg of fibrinogen) and 10^6
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Why would you give single donor platelets?
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Limit exposure (for HLA immunization), refractoriness..
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What is leukocyte reduction not indicated for?
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Transfusion of anything that is previously frozen, prevention of GVHD...
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What do you leukocyte reduce for?
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Prevent febrile nonhemolyt ic transfusion reactions, preventions of cmv trasnmission, prevention of imunruppressive effects of transfusion, reduction of bacterial contamination.
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What is the standard for leukocyte depleted prbc?
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At least 85% of original RBC's and <5 x10^6 white cells in all units.
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What are the standards for leukocyte reduced platelets concentrate?
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5.0x10^10 platelets in 75% of the units and <8.3 x10^5 wbc
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What about leukocyte reduced apheresis platelets?
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3.0x10^11 platelets in 75% and <5x10^6 wbc's in all units. (fda proposed to lower to 1x10^6)
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What are the two main types?
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You can do prestorage (which is more preferable) or you can do pretransfusion.
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What are potential complicatoins?
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ace inhibitors (hypotension?), red eye syndrome
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What is washing and what kind of life do you have after washing?
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wash the cells with normal saline (1-2 L)
rbc (24 hours) platelets (4 hours) |
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What are the indications for washing?
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Removal of palsam proteins for people with iga deficiency , abo antibotides.
Alloimmune thrombocytopenic purpura in materal/fetal sort of reactions (washed maternal antibody does noth have the anti pl a1 or the hpa -1a. febrile nonhemolytic reactions (rbc's and platelets) (type 1 and type 2?) |
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why would you want to freeze either platelets or prbc?
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autologous, plasma hypersensitivies
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What kind of storage time are you talkin about?
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glycerol (40/20%) (-65C/-120C) you have 24 hours after at 1-6 C
platelets have no defined and are about 4 horus after dmso |
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What do we irradiate?
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We irradiate to prevent GVHD from transfusion. Neonates,hematologous malignancies, neonatal, SCID, Digeorge, HLA matched.. are all irradiated, HIV, organ transplants, aplastic anemia, nont at risk.
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What don't we use irradiation for? What is the maximum storage time on a red blood cell?
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preventing cmv transmission adn peripheral stem cell infusions. Maximum storag time on a rbc is 28 days.
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