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67 Cards in this Set

  • Front
  • Back
The intricate structure of the heart develops during the fist ___ of life
eight weeks
From what type of tissue does the heart develop:
mesoderm
When does the heart begin to beat:
on the 22nd day
Where does the heart start forming:
rostral to the oral plate, adjacent to the septum transversum
what happens on day 18 in the development of the heart:
small islands of blood and endothelial tissue begin to differentiate out of the mesoderm
When does blood and endothelial tissue begin to differentiate out of the mesoderm:
day 18
blood islands unite to form ___ shaped tube when during embryonic development: (what day)
horseshoe
days 18-19
what happens in the embryo heart in days 21-22: (x2)
Venous end receives blood from yolk sac
(body’s first functional veins)

Arteries begin to pump to the head, via early aortic arches
identify the structures:
(see figure)
As the heart grows why does it bend into an ‘S’ shape:
the heart grows at a faster rate than the pericardial cavity
The heart grows at a faster rate than the pericardial cavity, what is the result:
it bends into an ‘S’ shape
what is the name of the bulge in the 'S' shaped heart:
bulboventricular loop
identify the labeled structures:
embryonic heart age:
(see figure)
6th week
identify the labeled structures:
age of the embryonic heart:
(see figure)
8-9 weeks
As the heart develops, systemic veins move to drain into the ___ side of heart, systemic arteries move to arise from the ___ side of heart
right
left
how do the developing embryonic atria fuse and expand:
by incorporating veins into atrial walls
The rough-walled part of the atrium comes from ___ while the smooth-walled (sinus venarum) part comes from ___
embryonic atrium
venous origin
the __ develops in the center of the single atrial and ventricular cavity from ant. to post.
endocardial cushion
the ___ initially separates the 2 atria but there is open communication via the ___
septum primum
foramen primum
during embryonic development, the ___ separates the 2 ventricles and the ___ is the opening between them
interventricular septum
interventricular foramen
As foramen primum shrinks, a second foramen connecting the two atria forms called ___ and a second septum froms called the ___
foramen secondum
septum secondum
what happens in the final separation of the atria and ventricles: (x3)
(what's closed/open)
1. atria leave an opening called the foramen ovale

2. interventricular septum closes

3. truncus arteriosus closes
what is the function of the foramen ovale:
for blood to go from the IVC to the L. atrium
when the interventricular septum closes the membranous part arise from what:
endocardial cushion
the truncus arteriosus closes with a ___, separating the ___ from the ___
spiral septum
aorta
pulmonary trunk
in the fetus, SVC carries (high/low) oxygen blood from where:

IVC carries (high/low) oxygen blood from where:
low
head and upper limb

high
umbilical vein
how is blood routed through the right atrium from SCV:

IVC:
SVC blood goes directly through right atrium to right ventricle

IVC blood goes through foramen ovale to left atrium, and hence to left ventricle
the two Aorta and Pulmonary trunk separate out from a common truncus by means of a ___
spiral septum
the right ventricle is anterior, while the pulmonary trunk has to arise from the ___ of the aortic sac
posterior part
the left ventricle is posterior, while its Aorta has to arise from the ___ of the aortic sac
anterior part
The final result of the spiral septum is what:
aorta and pulmonary trunk that twist around each other
what are the great vessels:

from where do they arise:
aorta and pulmonary trunk

aortic arches
what are the aortic arches that develop in the human embryo:

arches ___ involute early, and leave no major remnant
1,2,3,4,and 6

1 and 2
what is the function of the umbilical artery:

what is the function of the vitelline artery:
supply deoxygenated blood from the fetus to the placenta

an artery carrying blood to the yolk sac from the embryo
___ that is high in O2 brings blood back from the maternal circulation and continues up to the liver as the ___ where it meets up with the ___ that is low in O2
umbilical vein
ductus venosus
portal vein
the ___ is brining some low O2 content blood from the GI tract up to the liver where it mixes with the high O2 blood from the ___ to form the ___
portal vein
ductus venosus
inferior vena cava
the ___ is brining fairly high O2 content blood to the right atrium, where the majority of the blood with squirt through the ___ into the ___
inferior vena cava
foramen ovale
left atrium
from the left atrium, the blood will go to the ___ and out the ___ and to the rest of the body from there
left ventricle
aorta
the ___ brings low O2 blood from the body and brings it in to the ___ where it then goes to the ___ and then out the ___
superior vena cava
right atrium
right ventricle
pulmonary trunk
the lungs aren't working yet so the blood from the ___ goes through the ___ and mixes with the aortic blood where it feeds all the tissues of the body and then leaves the body through the ___
pulmonary trunk
ductus arteriosus
umbilical arteries
what causes the foramen ovale to close: (4 steps)
1. stopping of umbilical circulation
2. (↓)IVC blood flow causing (↓)right atrial pressure
3. blood flows to expanding lungs through pulmonary circulation
4. (↑)blood flow to left ventricle
___ and other factors cause smooth muscle in ductus arteriosus and ductus venosus to contract, sealing off these ducts
oxygen tension
atrial septal defects occur in the ___ and allow what:
interatrial wall
mixing of blood between left and right atria
what is a probe-patent foramen ovale:
minor atrial septal defect
what is a high atrial septal defect:
hole up near the SVC, connecting the two atria
a typical atrial septum defect is caused by either 1 of 2 things:
1. too large of a foramen secundum
2. too large a fossa (foramen) ovalis
what is the cause of a septum primum defect:

what is the result of this defect:
failure of septum primum to completely fuse with endocardial cushion

a variably sized hole connecting the two atria
This septum defect is frequently found in patients with Down’s syndrome:
septum primum defect
what is the cause of the membranous ventricular septal defect:
failure of fusion of the interventricular septum with the endocardial cushion
(atrial/ventricular) septum defects are the most common:
ventricular
(membranous/muscular) septal defects are less common:
muscular
what are truncus defects caused by:
failure of the spiral septum of the truncus arteriosus
what are the affected structures in truncus defects: (x3)
ascending aorta
pulmonary trunk
semilunar valves
what is the cause of persistent truncus arteriousus:

what is the result in the newborn:
failure for truncus to separate at all

no separation of blood flows
no aortic or pulmonary valves
what is occurring in the defect transposition of great vessels: (x3)

why does this occur:
right ventricle pumps to aorta
left ventricle pumps to pulmonary trunk
no transfer of oxygen to systemic circulation

spiral septum is straight and not spiral
what is occurring in unequal division:

what does this usually involve so that a baby could survive:
one vessel has a large opening, the other is small (aorta/pulmonary trunk)

a VSD so rest of right ventricular blood can get into aorta
what is occurring in tetralogy of fallot:
1. pulmonary stenosis
2. VSD (ventricular septal defect)
3. Over-riding aorta (aorta sits right over the interventricular septum, collecting blood from both ventricles)
4. hypertrophy of right ventricle
what is ectopia cordis:
failure of sternum to fuse, producing a heart outside of the thoracic cavity
what is dextrocardia:

when is this not a big problem:
reverse rotation

situs inversus
what is persistent ductus arteriosus:
pulmonary by-pass to continues functioning
what is occurring in ductus arteriosus: (think pressure)
Flow reverses, so blood going from high pressure to low → goes from aorta to pulmonary trunk (with resulting pulmonary hypertension).
what is coarctation of the aorta:

what are the 2 forms:
inexplicable narrowing of the aorta near the ductus arteriosus

preductal forms and postductal forms
what is occurring in coarctation of the aorta: (blood pressure)
blood pressure to upper extremities is increased
blood pressure to lower extremities is minimal.
how do you detect coarctation of the aorta:
compare brachial pulse to femoral pulse in newborn
in coarctation of the aorta:

in which form does ductus arteriosus act to supply low-oxygen blood to lower extremities
preductal form
in coarctation of the aorta:

in which form does blood from aorta use ductus arteriosus as pressure relief valve:
postductal forms
what happens if blood from the aorta uses ductus arteriosus as a pressure valve:
pulmonary hypertension