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18 Cards in this Set
- Front
- Back
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process of membrane trafficking begins with the transport of material from the rER to the ... this is performed by budding off of membrane-bound vesicles called ...
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Golgi
transport vesicles |
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vesicles formed from the rER are coated on the ... side of the membrane by ... protein.
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cytoplasmic
COPII |
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The membranes of the transport vesicles lose their coat and fuse with the membranes of the ...-face of the ...
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cis
Golgi |
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transported material and membranes are then further transported through other stacks of the Golgi by a similar process of ... and ...
and along the way, cargo proteins are modified by various ... within the different stacks |
budding
fusion enzymes |
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terminal N- and O-glycosylation and phosphorylation of lysosomal enzymes happens in ...
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golgi
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cis-most cisternae contain a higher content of ... in their membranes and thus can be identified by osmium tetroxide reduction.
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lipid
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middle and trans-side cisternae contain a higher content of ... enzymes and can be identified by reactions for these enzymes activities.
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glycosylation
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trans-most cisternae (trans Golgi network) is the site where ... are produced and contain ... marker activities.
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lysosomes
lysosomal |
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identify what part of golgi is being stained:
a. b. c. |
a. middle and trans-side cisternae
b. cis-most cisternae c. trans-most cisternae |
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Golgi is the major center for trafficking of:
1. 2. 3. |
1. membrane proteins
2. secretory proteins 3. lysosomes |
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there is also a retrograde transport between the Golgi stacks and the ...
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rER
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retrograde transport involves an ER receptor and a coating protein called ... Thus, the ... is also the source of mature proteins for the ...
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COPI
Golgi rER |
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what are the 2 types of secretion for proteins:
1. 2. |
1. constitutive
2. regulated |
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digestion of extracellular substances and intracellular organelles by ... is called ...
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lysosomes
autophagy |
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lysosomal enzymes and lysosomal membrane proteins are transported to primary lysosomes by a ... system.
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mannose-6-phosphate receptor
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Several highly glycosylated integral membrane glycoproteins have been identified in lysosomes which have been found to be ... by lysosomal enzymes
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resistant to degradation
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the following are examples of what:
-Defects in genes that code specific enzymes -Molecules to be degraded build up & are stored in lysosomes -Some organs affected more than others -Most often kidney, liver & brain -Symptoms mild to death -I cell disease: Defect in M6P phosphotransferase – enzymes secreted |
Lysosomal Storage Diseases
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one of the glycosylated integral membarane proteins identified in the lysosome is an ATP-driven proton pump, which is believed to be responsible for ... found in the lumen of the lysosome
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maintenance of the pH < 5.0
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