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18 Cards in this Set

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process of membrane trafficking begins with the transport of material from the rER to the ... this is performed by budding off of membrane-bound vesicles called ...
Golgi
transport vesicles
vesicles formed from the rER are coated on the ... side of the membrane by ... protein.
cytoplasmic
COPII
The membranes of the transport vesicles lose their coat and fuse with the membranes of the ...-face of the ...
cis
Golgi
transported material and membranes are then further transported through other stacks of the Golgi by a similar process of ... and ...
and along the way, cargo proteins are modified by various ... within the different stacks
budding
fusion
enzymes
terminal N- and O-glycosylation and phosphorylation of lysosomal enzymes happens in ...
golgi
cis-most cisternae contain a higher content of ... in their membranes and thus can be identified by osmium tetroxide reduction.
lipid
middle and trans-side cisternae contain a higher content of ... enzymes and can be identified by reactions for these enzymes activities.
glycosylation
trans-most cisternae (trans Golgi network) is the site where ... are produced and contain ... marker activities.
lysosomes
lysosomal
identify what part of golgi is being stained:
a.
b.
c.
a. middle and trans-side cisternae
b. cis-most cisternae
c. trans-most cisternae
Golgi is the major center for trafficking of:
1.
2.
3.
1. membrane proteins
2. secretory proteins
3. lysosomes
there is also a retrograde transport between the Golgi stacks and the ...
rER
retrograde transport involves an ER receptor and a coating protein called ... Thus, the ... is also the source of mature proteins for the ...
COPI
Golgi
rER
what are the 2 types of secretion for proteins:
1.
2.
1. constitutive
2. regulated
digestion of extracellular substances and intracellular organelles by ... is called ...
lysosomes
autophagy
lysosomal enzymes and lysosomal membrane proteins are transported to primary lysosomes by a ... system.
mannose-6-phosphate receptor
Several highly glycosylated integral membrane glycoproteins have been identified in lysosomes which have been found to be ... by lysosomal enzymes
resistant to degradation
the following are examples of what:
-Defects in genes that code specific enzymes
-Molecules to be degraded build up & are stored in lysosomes
-Some organs affected more than others
-Most often kidney, liver & brain
-Symptoms mild to death
-I cell disease: Defect in M6P phosphotransferase – enzymes secreted
Lysosomal Storage Diseases
one of the glycosylated integral membarane proteins identified in the lysosome is an ATP-driven proton pump, which is believed to be responsible for ... found in the lumen of the lysosome
maintenance of the pH < 5.0