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23 Cards in this Set
- Front
- Back
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Responsible for the conjugation of bilirubin?
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UDP-glucuronate
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enzyme for
G-6-P --> G-1-P |
Phosphoglucomutase
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enzyme for
G-1-P --> UDP-Glucose |
G-1-P uridyltransferase
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UDP-Glucose can be used for the production of what?
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UDP-Galactose
UDP- glucuronate Glycogen proteoglycans & glycoproteins |
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enzyme for
UDP-glucose --> UDP-glucuronate |
UDP-glucose dehydrogenase
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what is degraded to make bilirubin?
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heme
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why is bilirubin conjugated with a sugar
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to make it more water soluble, because sugar is water soluble, that is how we excrete hydrophobic molecules (estrogen, testosterone, morphine, ect).
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enzyme for
UDP-Glucose --> UDP-Galactose |
Epimerase
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what is the leaving group in this rxn?
UDP-Galactose + Glucose = Lactose |
UDP, it is stable and therefore and good leaving group.
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UDP-Glucose and UDP-galactose are what to each other?
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Distereomers
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what is the starting material necessary for the manufacture of lactose?
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glucose, we do not need to take in lactose or galactose, we make them from glucose.
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what are the alcoholic amino acids?
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serine , threonine
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where does post-translational modification occur?
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ER and Golgi
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where does the nitrogen come from the the rxn
F-6-P --> Glucosamind-6-P |
glutamine, where glutamine is converted into glutamate
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all proteoglycans must gave an extensive network of....
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glycosylation
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do proteoglycans act more like carbohydrates or proteins?
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carbohydrates, 95% of a proteoglycan is carbohydrate, and 5% is protein.
(Hydrophilic) |
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where is one place that peoteoglycans are important?
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synovial fluid, resist conpression, and bind lots of water
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what modification designates transfer into the lysosome?
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mannose-6-phosphate
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what enzyme is there a problem with, if there is a defecency in turning mannose into mannose-6-phosphate?
What disease is this? |
phosphotransferase
I-cell disease (comonly occurs in the eye) |
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what happens in I-cell desease?
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proteins that are degredation enzymes will not be able to be transferred intp the lysosome, now the degredations enzymes are floating around in the cytosol.
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two examples of glycolipids
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Galactocerbroside (ceramide + glactose)
Ganglioside (ceremide + galactose + GalNac) |
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what is H substance?
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it is the glycolipid that we all have on our blood, all individuas can make the H substance, some of us have those modified to make type A, B, ect.
(frucose-galactose-NA-glucosamine) |
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Tay-Sachs Disease?
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Common in Jewish Population.
Inability to breakdown glycolipids Defecency of hexoaminidase-a (GM2 Galglioside Disease) |
