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21 Cards in this Set
- Front
- Back
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Mechanism of imatinib (gleevec)?
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Small molecule tyrosine kinase inhibitor blocking bcr/abl on Philadelphia chromosome intracellularly
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When is imatinib (gleevec) used?
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Chronic myeloid leukemia (CML)
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Mechanism of monoclonal antibodies?
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Bind to lingands/receptors extracellularly to disrupt cell processes
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Mechanism of bevacizumab?
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Binds VEGF to inhibit angiogenesis
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When is bevacizumab used?
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Metastatic colorectal and lung cancers
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Adverse effects with bevacizumab?
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GI perforation, impaired wound healing, hemorrhage, and hypertension
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Difference in small molecule inhibitors from monoclonal antibodies?
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Less specific targeting and metabolism via CYP450
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Mechanism of sunitinib?
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Intracellularly binds VEGFR2 among others (dirty drug)
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When is sunitinib used?
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Metastatic kidney cancer
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Adverse effects of sunitinib?
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Rash, hypothyroidism
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Most common anti-EGFR tyrosine kinase inhibitor?
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Erlotinib
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When is erlotinib used?
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Asian female non-smoker for lung cancer treatment
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Adverse effects of erlotinib?
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Rash, diarrhea
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Mechanism of cetuximab?
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Binds to EGFR to promote apoptosis
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When is cetuximab used?
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Colorectal and head/neck cancers
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Adverse effect of cetuximab?
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Rash
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Mechanism of trastuzumab?
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Extracellular binding of HER2, inhibits intracellular TK to inhibit cellular proliferation
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Mechanism of lapatinib?
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Inhibits intracellular signaling HER1/2
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What does petuzumab bind?
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HER2
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Mechanism of rituximab?
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Anti-CD20
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When is rituximab used?
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Treatment of lymphoma
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