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17 Cards in this Set
- Front
- Back
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Major problem with azole antifungals?
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Interaction with CYP 450 due to inhibition of fungal CYP 450
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Which azole does not have activity against aspergillus?
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Fluconazole
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DOC for aspergillus?
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Voriconazole
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The only azole that needs to be renally dosed?
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Fluconazole
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Major side effect of polyene Amphotericin B?
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Nephrotoxicity, infusion reactions
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Broadest spectrum antifungal?
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Amphotericin B
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DOC for C. albicans and C. galbrata?
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Echinocandins
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Major side effect for flucytosine?
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Dose-dependent bone marrow suppression
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Antifungals for dermatophytes?
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Terbinafine, griseofulvin
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What do all antifungals cause?
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Hepatotoxicity
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Antifungals that penetrate the urine?
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Fluconazole, amphotericin B
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Major difference between ganciclovir and acyclovir?
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Ganciclovir covers CMV
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Major side effect of acyclovir and valganciclovir?
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Bone marrow suppression
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A cytosine nucleotide that does not require viral activation?
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Cidofovir
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Major side effect of foscarnet?
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Nephrotoxicity
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Major side effect of adamantanes?
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CNS effects: nervousness, lightheadedness, inability to concentrate
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Major issue with neuramidase inhibitor zanamivir?
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Inhalation may exacerbate COPD
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