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19 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Disease and organism?
-Associated with relapsing and remitting course of fever spread person to person -Found esp in areas of overcrowding, poverty and poor sanitation -spread by body louse |
Borrelia recurrentis (relapsing fever)
EPIDEMIC louse-borne relapsing fever |
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Bug and disease?
-obligate intracellular organisms; grow in cytoplasm and nucleus - Vectors of transmission are Dermacentor ticks -Dogs and other warm-blooded animals are reservoirs - More common in southeastern US |
Rickettsia ricketssii (Rocky Mountain Spotted Fever)
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The following is dx for what disease and assocated organism?
-Red, ring shaped lesion with central clearing at site of the tick bite -Usually found on thigh, groin, trunk, armpits -Lesions may have a central target |
Lyme disease
Erythema chronicum migrans Borrelia burgdorferi Vector of transmission is the Ixodes tick -White-tailed deer, bear, and white-footed mice are reservoirs |
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Virulence factor and organism?
-Antigenic determinants on cell surface that vary as selective pressure -Cells recognized by host are killed - genes are activated by gene conversion -Single clone can give rise to 20 distinct serotypes |
Variable major protein (VMP)
Borrelia recurrentis (relapsing fever) hint: selection varies |
selection varies
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What transmits the organism associated with Lyme disease?
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Borrelia burgdorferi
Vector of transmission is the Ixodes tick |
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Organism and disease?
-small, slightly curved G(-) rods aspirated pus from nodes - Diagnosis often made by serology coupled with clinical findings -fluorescent Ab test also can id |
Bartonella henselae (Cat Scratch Disease, bacillary angiomatosis, peliosis)
A Rickettsia |
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Organism and disease?
-person goes camping and drinks from local stream -spirochetes that can be visualized with dark field microscopy -serotype - specfic Ab titers are measured can cause: Hepatitis Bacteriuria in kidney Scleral hemorrhage in CSF and aqueous humor |
Leptospira spp. (Leptospirosis)
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Oraganism and disease?
-Target organ enlargement -Associated with Weight loss, nausea, fever -Elevated alkaline phosphatase levels |
Bartonella henselae – a Rickettsia
(Cat Scratch Disease, bacillary angiomatosis, peliosis) Sx Associated with immunocompromise (AIDS) |
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Disease and bug?
-Relapsing and remitting fever spread by soft tick bit -rodents act as reservoirs -common with visiting cabin or rustic area |
Borrelia recurrentis (relapsing fever)
ENDEMIC tick-borne relapsing fever |
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Organism?
Small G(-) Oxidase (+) bacilli -Infection of humans usually associated with cat or dog bite or scratch -Focal soft tissue infection (cellulitis) within 1-2 days after bite or scratch |
Pasteurella multocida
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Organism and disease?
Uniquely associated with Petechial (minute, non-blanching) or maculopapular (flat, papule) rash on extremities as well as with rash spreads CENTRIPETALLY, involving palms and soles |
Rickettsia ricketssii
(Rocky Mountain Spotted Fever) |
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What stage of lyme disease associated with bacteria are multiplying in tissue and disseminating, also associated with fatigue, fever and chills, myalgia, and arthralgia?
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Early and first stage of Lyme disase
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Spirochetes from peripheral blood smear (Giemsa stain) associated with Jarisch-Herxheimer reaction (fever, chills, myalgia)
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Borrelia recurrentis (relapsing fever)
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What organism and disease is assocated with symptoms including skin lesions, arthritis, neurological problems and thought to be due to autoimmune process (antigenic cross-reactivity)?
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Tertiary stage – chronic
Borrelia burgdorferi (Lyme disease) |
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Organism, disease and susceptible pt pop?
Cats are reservoirs of infection; bacteria are introduced by cat bites, scratches, licks - Cause of chronic lymph node swelling in children -. Regional lymphadenopathy, lesions may suppurate |
Bartonella henselae
(Cat Scratch Disease, bacillary angiomatosis, peliosis) AIDS PT A Rickettsia |
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Bug?
G(-)spirochete Presents with Red, ring shaped lesion & flu-like symptoms Organism can be cultured and stained; Gram or immunostain from Blood, CSF, or synovial fluid samples |
Borrelia burgdorferi (Lyme disease)
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Organism and disease?
-G(-) coccobacillary (stains poorly) - Complement fixation with antigen; 4-fold rise in titer -Indirect immunofluorescence with antigens; IgG, IgM detected -used to use weil-felix test |
Rickettsia ricketssii
(Rocky Mountain Spotted Fever) |
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Why is Borrelia recurrentis produces a disease that has a relapsing course?
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Bc of the virulence factor, Variable major protein (VMP)
--> Antigenic determinants on cell surface that vary as selective pressure --> Relapsing course of disease corresponds to variation in antigenic structure |
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Why does a pt infected with Borrelia recurrentis (relapsing fever) develop Jarisch-Herxheimer reaction?
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Release of VMP from dying spirochetes triggers local inflammatory response (release of cytokines [esp. TNF-α] & chemokines)
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