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31 Cards in this Set
- Front
- Back
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InI A and InI B
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invasion
L. monocytogenes |
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Hly
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intracellular survival
L. monocytogenes |
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ActA
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cell - to - cell spread
L. mononcytogenes |
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LLO
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Listeriolysin O
escape from host cell vacuoles L. mononcytogenes |
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CpbA
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binds to CHO on cell surface
s. pneumoniae also PspA - another adhesion virulence factor |
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virulence factors of N. meninigitis
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IgA protease
Pili - adhere to epithelium LOS - like LPS (toxic & pro-inflammatory) Capsule - A,B,C,Y, W135 |
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virulence factors for H. influenza
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polyribitol capsule (Quellung (+))
IgA protease Pili endotoxin (LPS) OMP = outer membrane protien H. influenza is G(-) facultatiave anaerobe |
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virulence factors for Campylobacter Jejuni
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G(-) microaerophilic
Oxidase (+) Catalase (+) for attachment and colonization of gut epithelium: chemotaxis, motility, flagella also Iron aquisition, host cell invasion, toxin production and epithelial disruption |
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What organisms have capsules?
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s. pneumoniae
n. meningitides h. influenzae s. aglactiae (GBS) cryptococcus neoformans |
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virulence factor for s. pneumnoniae
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capsule
IgA protease |
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Kps protien
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K1 Capsule of E. coli K1
composed of K1 Antigen -antiphagocytic -serum resistnat |
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LPS
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lipopolysaccharide
found on G(-) like E. Coli K1 endotoxin induce IL-1 and TNF to produce shock and fever |
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Csp protien
Clp protien |
Csp protien = capsule
Clp protien - ATP protease GBS = S. Agalactiae |
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melanin
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dark pigment that protects against oxidative defenses of macrophages
associated with cryptococcus neoformans |
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Pla
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pneumolysis
-cytotoxin release when bateria lysis, also inhibits antibody binding to bacteria s. pneumoniae |
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LytA
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Autolysin
-release of this protien causes bacteria (S. pneumoniae) to release intracellular contents including Pla |
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spherules
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arthroconidia transform into spherical cells called spherules
coccidiodes imitis (valley fever) |
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oocyst transforms into tachyzoites with tissue cyst develop in brain
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Toxoplasma gondi
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translocated into the lumen and released from the
C’terminus of E by signal peptidase. It is a membrane soluble haemagglutinin and elicits humoral immune responses and immunization with purified protein can be protective |
NS1 protein:
flavivirus |
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L, 2A, 3C
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proteases for Picronavirus
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NS3
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proteases for Flavivirus
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It is a 63-kDa protein, involved in RNA
synthesis |
3D (RNA dependent RNA polymerase)
Viral non-structural proteins Picornovirus |
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translocates the NS1 protein into lumen of ER. Play a critical role in binding to cell surface receptors and subsequent viral entry
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E protein:
flavivirus |
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a protease, implicated between p2 and p3 cleavage
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3C protein
Viral non-structural proteins Picornovirus |
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RNA dependent RNA polymerase (RdRP)of flaviviruses
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NS5
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VP1, VP2, VP3 and VP4
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capsid protien for picornoviruses
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C protein
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capsid protien for flaviviruses
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proteins which may play an essential role in the pathogenesis of the HTLV-1 associated diseases
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Structural regulatory (Tax and Rex) and several additional proteins
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Stimulates the 3D pol activity as well as the proteolytic activity of 3CDpro
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3AB protein
Viral non-structural proteins Picornovirus |
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similar hydrophobic sequences at C-terminal of the prM cause the translocation of the E protein into lumen. PrM will be cleaved to pr and M
upon maturation of virion. |
PrM protein:
flavivirus |
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highly basic, forms ribonucleoprotein complex with genomic RNA. The C’terminal domain has a signal sequence to translocate the prM protein into the lumen of the ER to be processed as membrane protein.
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C Protein of flaviviruses
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