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17 Cards in this Set
- Front
- Back
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wound healing - immediate inflammatory
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- Platelet, neutrophils, macrophages
- clot, vessel permeability, neutrophil migration - cleared by macs in 2 days |
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wound healing - proliferative - 2-3 days
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- fibroblasts, myofibroblasts, endothelial cells, keratinocytes, macrophages
- deposition of granulation tissue and collagen - angiogenesis, epth cell proliferation |
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wound healing - remodling - 1 week
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- fibroblasts
- Type 3 collagen replaced by type 1 - inc tensile strenght of tissue |
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Granulomatous diseases
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1. Mycobac TB
2. Fungal: histoplasmosis; coccidiomycosis 3. Treponema pallidum 4. M. leprae 5. Bartonella hensale - cat scratch 6. Sarcoidosis 7. Crohn's disease 8. Wegners - polyangiitis 9. Churg Strauss 10. Berylliosis, silicosis |
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Granuloma formation
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T cells --> INFy --> Macs --> TNFa --> maintain granuloma
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Transudate
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due to: inc hydrostatic pressure, dec oncotic pressure, Na retention
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Exudate
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due to: lymphatic obstruction, inflammation
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High ESR
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Infection
inflammation cancer pregnancy SLE Polymyalgia rheumatical temporal arteritis osteomyelitis malignancy |
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Low ESR
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Sickle cell
Polycythemia CHF |
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Iron Poisoning
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mech: cell death d2 peroxidation of membrane lipida
sx: acute -gastric bleeding chronic - metabolic aciosis, scarring leading to GI obstruction |
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Amyloidosis
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- waxy appearance
- beta pleated sheets of protein |
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AL (primary) amyloid
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- deposition of Ig Light chain
- plasma cell disorder or multiple myeloma - multiple organ system impacted |
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AA (secondary) amyloid
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- chroinc diseases like: RA, IBD, spondyloarthropathy, chronic infection
- fibrils of serum Amyloid A - often multi system |
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Dialysis related amyloid
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- beta 2 microglobulin
- presents as carpal tunnel and other joint issues |
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heritable amyloid
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neurologic/cardiac - transthyretin (TTR or prealbumin) gene mutation
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Age related senile systemic amyloid
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deposition of nl TTR in myocardium and other sytes
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organ specific amyloid
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localized to single organ
Alzheimer's - amyloid beta protein cleaved from amyloid precursor protein (APP) |
