Wound Healing

Front 1

Abrasion

Back 1

Wound caused by scraping or friction to the skin's surface.

Front 2

Angioblasts

Back 2

Endothelial cell that lines vessel walls.

Front 3

Angiogenesis

Back 3

Formation of new blood vessels

Front 4

Chemotactic Agents

Back 4

Substance that attracts cells.

Front 5

Chemotaxis

Back 5

Movement along a chemical gradient.

Front 6

Closed Wound

Back 6

A wound in which the epithelial integrity has been restored.

Front 7

Collagenase

Back 7

Enzyme that breaks down collagen.

Front 8

Contracture

Back 8

Pathological shortening of scar tissue resulting in a deformity.

Front 9

Current of injury

Back 9

Local change of polarity at the site of integumentary injury.

Front 10

Cyotkines

Back 10

Signaling protein during the inflammatory phase of wound healing.

Front 11

Cytotoxic Agents

Back 11

Substance that is poisonous to human cells.

Front 12

Dehiscence

Back 12

Separation of wound margins.

Front 13

Delayed primary closure

Back 13

A combination of primary and secondary wound healing processes in which the wound is first observed before primary closure.

Front 14

Diapedesis

Back 14

The movement of PMNs through capillary walls.

Front 15

Epibole

Back 15

Keratinocyte migration over the lip or margin of the dermis

Front 16

Epithelialization

Back 16

Process by which keratinocytes resurface the wound defect.

Front 17

Exudate

Back 17

Mixture of fluid, high levels of protein, and cells.

Front 18

Fibroblast

Back 18

Dermal cell that produces collagen, elastin, granulation tissue, and growth factors.

Front 19

Granulation Tissue

Back 19

Temporary structure composed of vascularized connective tissue that fills the wound void.

Front 20

Growth Factors

Back 20

Growth promoting substance that increases or enhances cell size, proliferation, or activity.

Front 21

Healed Wound

Back 21

A closed wound with tissue strength approaching normal.

Front 22

Histamine

Back 22

Chemical mediator released by mast cells that causes vasodilation, increases vessel wall permeability, and attracts other cells to the area.

Front 23

Hypergranulation

Back 23

Error of proliferative phase in which too much granulation tissue is formed and epithelialization is delayed.

Front 24

Hypertrophic Scarring

Back 24

Overproduction of collagen that stays within the confines of the original wound.

Front 25

Hypogranular

Back 25

A pothole-type wound that fails to build a sufficient granulation tissue matrix.

Front 26

Inflammation

Back 26

First phase of wound healing, characterized by rubor, calor, tumor, dolor, and functiolaesa; vascular and cellular response to injury of living tissue.

Front 27

Integrins

Back 27

Cell surface receptors that allow cells to reversibly bind to extracellular matrix.

Front 28

Keloids

Back 28

Scar due to the overproduction of collagen that extends beyond the confines of the original wound.

Front 29

Macrophages

Back 29

Cell that directs the repair process, secretes growth factors and enzymes, and destroys bacteria and debris.

Front 30

Margination

Back 30

When PMNs are pushed to the sides of a vessel wall.

Front 31

Mast Cells

Back 31

Cell that helps initiate inflammation; secretes histamine, enzymes, and chemical mediators.

Front 32

Matrix Metalloproteases (MMPs)

Back 32

Proteases that degrade the extracellular matrix.

Front 33

Maturation/Remodeling

Back 33

Final phase of wound healing during which collagen matures and reorients along the lines of stress.

Front 34

Myofibroblasts

Back 34

Cell possessing properties of fibroblasts and smooth muscle cells that cause wound contraction.

Front 35

Platelets

Back 35

Cell that helps control bleeding; releases growth factors and chemotactic agents.

Front 36

Polymorphonuclear Neutrophils (PMNs)

Back 36

Cell that cleans the wound; secretes enzymes and inflammatory mediators.

Front 37

Primary Closure

Back 37

Process by which wound heal if the wound margins can be approximated.

Front 38

Proliferation

Back 38

Second phase of wound healing; building and regenerating phase consisting of angiogenesis, granulation tissue formation, wound contraction, and epithelialization.

Front 39

Prostaglandins

Back 39

Substance released by injured cells that cause vasodilation.

Front 40

Scab

Back 40

Collection of necrotic cells, fibrin, collagen, and platelets that covers a superficial wound.

Front 41

Secondary Closure

Back 41

Wound healing process in which granulation tissue is formed to fill the wound defect.

Front 42

Tissue inhibitors of matrix metalloproteases (TIMPs)

Back 42

Proteases that regulate the activity of MMPs

Front 43

Transudate

Back 43

Low-protein collection of fluid caused by increased vascular permeability.

Front 44

Wound Contraction

Back 44

Process by which myofibroblasts pull wound margins closer together, thereby decreasing the size of the defect.