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10 Cards in this Set
- Front
- Back
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Hemostasis |
Platelets- release cytokines PDGF, TGF-B, EGF |
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Inflammatory Phase- tissue debris and pathogens |
Attract macrophages and neutrophils, which are responsible for: phagocytosis; producing biological regulators, bioactive lipids, and proteolytic enzymes |
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Proliferative phase: fibroblasts |
Responsible for: synthesizing and depositing extracellular proteins; producing growth factors; producing angiogenesis factors |
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ECM and granulation tissue |
ECM composed of: collagen and elastin; adhesive proteins; fibronectin and lamina; polysaccharides; proteoglycans; glycosaminoglycans |
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Angiogenesis |
Capillary growth into ECM |
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Reepithelization |
Migration of marginal basal cells across the provisional matrix |
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Wound contraction |
Contraction of fibroblasts and myofibroblasts to bring wound edges closer |
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Maturation |
Scar- collagen deposition and remodeling; differentiations of fibroblasts into myofibroblasts with programmed cell death (apoptosis) |
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Resultant scar |
Formation of a scar, an avascular, acellular mass of collagen |
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Role of MMP’s (protease) |
Contract wound matrix through use of myofibroblasts; implement angiogenesis; migrate cells; remodel scar, remove damaged ECM |
