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24 Cards in this Set

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Onset is 12-24 hrs
Bulk-Forming Laxatives
↓ plasma cholesterol
psyllium
↓ intestinal absorption of many Rx (e.g. salicylates, digoxin)
Bulk-Forming Laxatives
Oral onset within 4 hrs
Saline Laxatives
-MgSO4
-Mg(OH)2
-Mg Citrate
-Na+Phosphate/Biphosphate (Fleet Phospho-Soda):
Laxative onset is 1-3 days
Lactulose (Chronulac, Cephulac)
used to tx hepatic encephalopathy
Lactulose
MOA of these Rxs are:
1) inhibits Na+-K+ATPase → fluid/electrolyte accumulation in lumen
2) ↑ synthesis of PGs & cAMP → ↑ fluid/ electrolyte secretion
Stimulant Laxatives(Irritants)
-Bisacodyl (Dulcolax)
-Sennosides (Senokot)
onset is 6-12 h
Stimulant Laxatives(Irritants)
-Bisacodyl (Dulcolax)
-Sennosides (Senokot)
Chronic use can→ Melanosis Coli –dark pigmentation of colonic mucosa. Benign & reversible, but suggests abuse. Also discolor urine into yellowish brown & red.
Sennosides (Senokot)
MOA: Anionic surfactants; softening stool → allow water & lipids to penetrate.
Docusates: Stool softeners
Docusate Na+
Docusate Ca 2+
Docusate K+ (Dialose)
onset of docusates
1-3 days.
May ↑ absorption of other Rxs → ↑ Rx toxicity
Docusates: Stool softeners
Docusate Na+
Docusate Ca 2+
Docusate K+ (Dialose)
A 5-HT4 partial agonist for Chronic constipation & irritable bowel syndrome with constipation
Tegaserod
the most effective & prompt acting nonspecific antidiarrheal agents.
Opioids:
-Diphenoxylate + atropine (Lomitil)
-Loperamide (Imodium)
opiod Side effects
anti-SLUD
For Travelers’ diarrhea.
Caution: Turns tongue & stool black
Bismuth Subsalicylate (PeptoBismol)
Sulfasalazine
Mesalamine (5-ASA)
Olsalazine (Dipentum)
Octreotide (Sandostatin)
Tx with Diarrhea with Inflammatory Bowel Disease (IBD)& AIDS
Ondansetron (Zofran)Granisetron (Kytril)
Alosetron (Lotrenex)
are antiemetics that act by
blocking 5-HT3
Chloropromazine (Thorazine)
Promethazine (generic)
Prochlorperazine (Compazine)
Promethazine (Phenergan) Droperidol (Inapsine)
D2 antagonists
Mixed D2/5HT3 Antagonist
Metoclopramide (Reglan)
SE: Extrapyramidal reactions
D2 Antagonists
Prochlorperazine (Compazine)
Promethazine (Phenergan) Droperidol (Inapsine)
MOA of Antihistamines:
Diphenhydramine (Benadryl)
Meclizine (Antivan)
Cyclizine (Marezine)
↓ impulse from vestibular apparatus
Anticholinergic that is Best for motion sickness
Scopolamine (Transderm-Scop)
Substance P Receptor Antagonist
Aprepitant (Emend)