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31 Cards in this Set
- Front
- Back
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Acute Lymphocytic/Lymphoblastic Leukemia
Clinical CBC Labs Prognostic Indicators Other Tx |
Clinical: Peak age 4; CNS & testes sequester cells
Labs: TdT+ PAS+ 80% Pre-B CD10 (CALLA); CD19 Pre-T: CD7, 2, 3 Prognostic Indicators: Hyperploidy Good t9:22 poor Peripheral Blasts >100k poor PreT worse than PreB Other: Respiratory Sx Due to Pre-T Mediastial Mass Compression Tx: Combo chemotherapy, CNS Tx, 90% remit, 2/3 cured, treatment sequelae |
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Acute Myelocytic/Myeloblastic Leukemia
Clinical Labs Prognostic Indicators Other Tx Prognosis |
Clinical: Peak 25
Labs: Myeloperoxidase +, Aur Rods, M1-3 Types: based on degree of differentiation M0-2: Myeloblastic M3: Promyelocyteic t15:17 PML:RAR, granules and Auer rods --DIC: PT, PTT prolonged, D-Dimer inc. platelets fibrinogen dec M4-M7 lineage Prognostic Indicators: Dvlpt from MDS (del5q;7q, etc) poor Other: Chloroma = granulocyte sarcoma leukemia cutis = skin involvment; gingival infiltrates in monoblastic Tx:Combo chemo, 60% remit, 20% cure, Marrow translant curative PML tx w/ retinoic acid |
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Chronic Lymphocytic/Lymphoblastic Leukemia
Clinical CBC Labs Prognostic Indicators Tx |
Most Common Adult Leukemia in West
Clinical: 50+yo men; enlarged lymph nodes = SLL CBC >4k lymphocytosis, small uniform, dark appear mature possible anemia, thrombocytopenia; SMUDGE CELLS Labs: CD19, 20, 23, 5 Prognostic Indicators: Median 5 years Zap70 positive = naieve, poor prognosis Zap70 negative w/ Low [lymphos] = 10+ years Tx: palliative, anti-CD20 Marrow transplant if younger |
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Chronic Myelocytic/Myeloblastic Leukemia
Clinical CBC Labs Prognostic Indicators Other Tx Prognosis |
Any Age peak 25-60, Splenomegaly
CBC: Granulocytosis with Left Shift (incl Eos & Basos) Anemia Present, Mild Platelet Increase Labs: 90% have Philadelphia 9:22 100% have BCR-ABL Leukocyte Alkaline Phosphatase (LAP) Low Prognostic Indicators: 3 years w/o Tx Death via Accelerated Phase Blast Crisis ALL or AML type Tx:Imatinib = long remissions Marrow transplant = cure |
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TdT+ PAS+ Leukemia
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Acute Lymphocytic/Lymphoblastic Leukemia
Clinical: Peak age 4; CNS & testes sequester cells Labs: TdT+ PAS+ 80% Pre-B CD10 (CALLA); CD19 Pre-T: CD7, 2, 3 Prognostic Indicators: Hyperploidy Good t9:22 poor Peripheral Blasts >100k poor PreT worse than PreB Other: Respiratory Sx Due to Pre-T Mediastial Mass Compression Tx: Combo chemotherapy, CNS Tx, 90% remit, 2/3 cured, treatment sequelae |
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CD10; CD19 Leukemia
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Pre-B Acute Lymphocytic/Lymphoblastic Leukemia
Clinical: Peak age 4; CNS & testes sequester cells Labs: TdT+ PAS+ 80% Pre-B CD10 (CALLA); CD19 Pre-T: CD7, 2, 3 Prognostic Indicators: Hyperploidy Good t9:22 poor Peripheral Blasts >100k poor PreT worse than PreB Other: Respiratory Sx Due to Pre-T Mediastial Mass Compression Tx: Combo chemotherapy, CNS Tx, 90% remit, 2/3 cured, treatment sequelae |
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CD7, 2, 3 Leukemia
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Pre-T Acute Lymphocytic/Lymphoblastic Leukemia
Clinical: Peak age 4; CNS & testes sequester cells Labs: TdT+ PAS+ 80% Pre-B CD10 (CALLA); CD19 Pre-T: CD7, 2, 3 Prognostic Indicators: Hyperploidy Good t9:22 poor Peripheral Blasts >100k poor PreT worse than PreB Other: Respiratory Sx Due to Pre-T Mediastial Mass Compression Tx: Combo chemotherapy, CNS Tx, 90% remit, 2/3 cured, treatment sequelae |
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Hyperploid Acute Lymphocytic/Lymphoblastic Leukemia
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Good Prognostic Indicator
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Peripheral Blasts 80k in Acute Lymphocytic/Lymphoblastic Leukemia
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Blasts <100k Good Prognostic Indicator
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Peripheral Blasts 120k in Acute Lymphocytic/Lymphoblastic Leukemia
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Blasts >100k Bad Prognostic Indicator
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t9:22
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Poorly Prognostic Acute Lymphocytic/Lymphoblastic Leukemia
Clinical: Peak age 4; CNS & testes sequester cells Labs: TdT+ PAS+ 80% Pre-B CD10 (CALLA); CD19 Pre-T: CD7, 2, 3 Prognostic Indicators: Hyperploidy Good t9:22 poor Peripheral Blasts >100k poor PreT worse than PreB Other: Respiratory Sx Due to Pre-T Mediastial Mass Compression Tx: Combo chemotherapy, CNS Tx, 90% remit, 2/3 cured, treatment sequelae |
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Leukemia with Respiratory Sx
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Acute Lymphocytic/Lymphoblastic Leukemia
Clinical: Peak age 4; CNS & testes sequester cells Labs: TdT+ PAS+ 80% Pre-B CD10 (CALLA); CD19 Pre-T: CD7, 2, 3 Prognostic Indicators: Hyperploidy Good t9:22 poor Peripheral Blasts >100k poor PreT worse than PreB Other: Respiratory Sx Due to Pre-T Mediastial Mass Compression Tx: Combo chemotherapy, CNS Tx, 90% remit, 2/3 cured, treatment sequelae |
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Leukemia at Age 4
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Acute Lymphocytic/Lymphoblastic Leukemia
Clinical: Peak age 4; CNS & testes sequester cells Labs: TdT+ PAS+ 80% Pre-B CD10 (CALLA); CD19 Pre-T: CD7, 2, 3 Prognostic Indicators: Hyperploidy Good t9:22 poor Peripheral Blasts >100k poor PreT worse than PreB Other: Respiratory Sx Due to Pre-T Mediastial Mass Compression Tx: Combo chemotherapy, CNS Tx, 90% remit, 2/3 cured, treatment sequelae |
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Leukemia at Age 25
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Acute Myelocytic/Myeloblastic Leukemia
Clinical: Peak 25 Labs: Myeloperoxidase +, Aur Rods, M1-3 Types: based on degree of differentiation M0-2: Myeloblastic M3: Promyelocyteic t15:17 PML:RAR, granules and Auer rods --DIC: PT, PTT prolonged, D-Dimer inc. platelets fibrinogen dec M4-M7 lineage Prognostic Indicators: Dvlpt from MDS (del5q;7q, etc) poor Other: Chloroma = granulocyte sarcoma leukemia cutis = skin involvment; gingival infiltrates in monoblastic Tx:Combo chemo, 60% remit, 20% cure, Marrow translant curative PML tx w/ retinoic acid |
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Myeloperoxidase + Leukemia
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Acute Myelocytic/Myeloblastic Leukemia
Clinical: Peak 25 Labs: Myeloperoxidase +, Aur Rods, M1-3 Types: based on degree of differentiation M0-2: Myeloblastic M3: Promyelocyteic t15:17 PML:RAR, granules and Auer rods --DIC: PT, PTT prolonged, D-Dimer inc. platelets fibrinogen dec M4-M7 lineage Prognostic Indicators: Dvlpt from MDS (del5q;7q, etc) poor Other: Chloroma = granulocyte sarcoma leukemia cutis = skin involvment; gingival infiltrates in monoblastic Tx:Combo chemo, 60% remit, 20% cure, Marrow translant curative PML tx w/ retinoic acid |
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Auer Rods
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Acute Myelocytic/Myeloblastic Leukemia
Clinical: Peak 25 Labs: Myeloperoxidase +, Aur Rods, M1-3 Types: based on degree of differentiation M0-2: Myeloblastic M3: Promyelocyteic t15:17 PML:RAR, granules and Auer rods --DIC: PT, PTT prolonged, D-Dimer inc. platelets fibrinogen dec M4-M7 lineage Prognostic Indicators: Dvlpt from MDS (del5q;7q, etc) poor Other: Chloroma = granulocyte sarcoma leukemia cutis = skin involvment; gingival infiltrates in monoblastic Tx:Combo chemo, 60% remit, 20% cure, Marrow translant curative PML tx w/ retinoic acid |
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Leukemia Dvlpt from MDS
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Acute Myelocytic/Myeloblastic Leukemia
Clinical: Peak 25 Labs: Myeloperoxidase +, Aur Rods, M1-3 Types: based on degree of differentiation M0-2: Myeloblastic M3: Promyelocyteic t15:17 PML:RAR, granules and Auer rods --DIC: PT, PTT prolonged, D-Dimer inc. platelets fibrinogen dec M4-M7 lineage Prognostic Indicators: Dvlpt from MDS (del5q;7q, etc) poor Other: Chloroma = granulocyte sarcoma leukemia cutis = skin involvment; gingival infiltrates in monoblastic Tx:Combo chemo, 60% remit, 20% cure, Marrow translant curative PML tx w/ retinoic acid |
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Chloroma
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Acute Myelocytic/Myeloblastic Leukemia
Clinical: Peak 25 Labs: Myeloperoxidase +, Aur Rods, M1-3 Types: based on degree of differentiation M0-2: Myeloblastic M3: Promyelocyteic t15:17 PML:RAR, granules and Auer rods --DIC: PT, PTT prolonged, D-Dimer inc. platelets fibrinogen dec M4-M7 lineage Prognostic Indicators: Dvlpt from MDS (del5q;7q, etc) poor Other: Chloroma = granulocyte sarcoma leukemia cutis = skin involvment; gingival infiltrates in monoblastic Tx:Combo chemo, 60% remit, 20% cure, Marrow translant curative PML tx w/ retinoic acid |
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Leukemia Cutis
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Acute Myelocytic/Myeloblastic Leukemia
Clinical: Peak 25 Labs: Myeloperoxidase +, Aur Rods, M1-3 Types: based on degree of differentiation M0-2: Myeloblastic M3: Promyelocyteic t15:17 PML:RAR, granules and Auer rods --DIC: PT, PTT prolonged, D-Dimer inc. platelets fibrinogen dec M4-M7 lineage Prognostic Indicators: Dvlpt from MDS (del5q;7q, etc) poor Other: Chloroma = granulocyte sarcoma leukemia cutis = skin involvment; gingival infiltrates in monoblastic Tx:Combo chemo, 60% remit, 20% cure, Marrow translant curative PML tx w/ retinoic acid |
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Most Common Adult Leukemia in West
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Chronic Lymphocytic/Lymphoblastic Leukemia
Clinical: 50+yo men; enlarged lymph nodes = SLL CBC >4k lymphocytosis, small uniform, dark appear mature possible anemia, thrombocytopenia; SMUDGE CELLS Labs: CD19, 20, 23, 5 Prognostic Indicators: Median 5 years Zap70 positive = naieve, poor prognosis Zap70 negative w/ Low [lymphos] = 10+ years Tx: palliative, anti-CD20 Marrow transplant if younger |
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Leukemia in a 55 yo
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Chronic Lymphocytic/Lymphoblastic Leukemia
Clinical: 50+yo men; enlarged lymph nodes = SLL CBC >4k lymphocytosis, small uniform, dark appear mature possible anemia, thrombocytopenia; SMUDGE CELLS Labs: CD19, 20, 23, 5 Prognostic Indicators: Median 5 years Zap70 positive = naieve, poor prognosis Zap70 negative w/ Low [lymphos] = 10+ years Tx: palliative, anti-CD20 Marrow transplant if younger |
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Smudge Cells
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Chronic Lymphocytic/Lymphoblastic Leukemia
Clinical: 50+yo men; enlarged lymph nodes = SLL CBC >4k lymphocytosis, small uniform, dark appear mature possible anemia, thrombocytopenia; SMUDGE CELLS Labs: CD19, 20, 23, 5 Prognostic Indicators: Median 5 years Zap70 positive = naieve, poor prognosis Zap70 negative w/ Low [lymphos] = 10+ years Tx: palliative, anti-CD20 Marrow transplant if younger |
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Zap70
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Chronic Lymphocytic/Lymphoblastic Leukemia
Clinical: 50+yo men; enlarged lymph nodes = SLL CBC >4k lymphocytosis, small uniform, dark appear mature possible anemia, thrombocytopenia; SMUDGE CELLS Labs: CD19, 20, 23, 5 Prognostic Indicators: Median 5 years Zap70 positive = naieve, poor prognosis Zap70 negative w/ Low [lymphos] = 10+ years Tx: palliative, anti-CD20 Marrow transplant if younger |
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small dark uniform mature lymphocytosis
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Chronic Lymphocytic/Lymphoblastic Leukemia
Clinical: 50+yo men; enlarged lymph nodes = SLL CBC >4k lymphocytosis, small uniform, dark appear mature possible anemia, thrombocytopenia; SMUDGE CELLS Labs: CD19, 20, 23, 5 Prognostic Indicators: Median 5 years Zap70 positive = naieve, poor prognosis Zap70 negative w/ Low [lymphos] = 10+ years Tx: palliative, anti-CD20 Marrow transplant if younger |
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CD19, 20, 23, 5 Leukemia
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Chronic Lymphocytic/Lymphoblastic Leukemia
Clinical: 50+yo men; enlarged lymph nodes = SLL CBC >4k lymphocytosis, small uniform, dark appear mature possible anemia, thrombocytopenia; SMUDGE CELLS Labs: CD19, 20, 23, 5 Prognostic Indicators: Median 5 years Zap70 positive = naieve, poor prognosis Zap70 negative w/ Low [lymphos] = 10+ years Tx: palliative, anti-CD20 Marrow transplant if younger |
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Leukemia with Splenomegally
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Chronic Myelocytic/Myeloblastic Leukemia
Any Age peak 25-60, Splenomegaly CBC: Granulocytosis with Left Shift (incl Eos & Basos) Anemia Present, Mild Platelet Increase Labs: 90% have Philadelphia 9:22 100% have BCR-ABL Leukocyte Alkaline Phosphatase (LAP) Low Prognostic Indicators: 3 years w/o Tx Death via Accelerated Phase Blast Crisis ALL or AML type Tx:Imatinib = long remissions Marrow transplant = cure |
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Leukemia with Granulocytosis with Left Shift, and Anemia
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Chronic Myelocytic/Myeloblastic Leukemia
Any Age peak 25-60, Splenomegaly CBC: Granulocytosis with Left Shift (incl Eos & Basos) Anemia Present, Mild Platelet Increase Labs: 90% have Philadelphia 9:22 100% have BCR-ABL Leukocyte Alkaline Phosphatase (LAP) Low Prognostic Indicators: 3 years w/o Tx Death via Accelerated Phase Blast Crisis ALL or AML type Tx:Imatinib = long remissions Marrow transplant = cure |
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Philadelphia 9:22
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Chronic Myelocytic/Myeloblastic Leukemia
Any Age peak 25-60, Splenomegaly CBC: Granulocytosis with Left Shift (incl Eos & Basos) Anemia Present, Mild Platelet Increase Labs: 90% have Philadelphia 9:22 100% have BCR-ABL Leukocyte Alkaline Phosphatase (LAP) Low Prognostic Indicators: 3 years w/o Tx Death via Accelerated Phase Blast Crisis ALL or AML type Tx:Imatinib = long remissions Marrow transplant = cure |
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BCR-ABL
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Chronic Myelocytic/Myeloblastic Leukemia
Any Age peak 25-60, Splenomegaly CBC: Granulocytosis with Left Shift (incl Eos & Basos) Anemia Present, Mild Platelet Increase Labs: 90% have Philadelphia 9:22 100% have BCR-ABL Leukocyte Alkaline Phosphatase (LAP) Low Prognostic Indicators: 3 years w/o Tx Death via Accelerated Phase Blast Crisis ALL or AML type Tx:Imatinib = long remissions Marrow transplant = cure |
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Imatinib
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Chronic Myelocytic/Myeloblastic Leukemia
Any Age peak 25-60, Splenomegaly CBC: Granulocytosis with Left Shift (incl Eos & Basos) Anemia Present, Mild Platelet Increase Labs: 90% have Philadelphia 9:22 100% have BCR-ABL Leukocyte Alkaline Phosphatase (LAP) Low Prognostic Indicators: 3 years w/o Tx Death via Accelerated Phase Blast Crisis ALL or AML type Tx:Imatinib = long remissions Marrow transplant = cure |
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Look at the features of all Leukemias
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On the word Document
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