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21 Cards in this Set

  • Front
  • Back
prothrombin time (PT)
coagulation screening test dependent primarily on Factors VII
(activated) partial thromboplastin time (PTT)
coagulation screen test dependent primarily on Factors X, VIII, and IX
factor VIII
one of procoagulant factors necessary for normal clot formation and conversion of fibrinogen and fibrin
von willebrand's factor (vWF)
large protein produced by endothelial that circulates in plasma as a multimer; serves as a carrier protein for Factor VIII
acquired inhibitor
substance (usually antibody) circulating in plasma that interferes with funciton of one or more procoagulant factors. acquired=not congenital, coming at some time later
fibrinogen (Factor I)
plasma protein that is acted upon by thrombin to make fibrin through cleavage of some portions
polypeptide derived from fibrinogen that links together to form fibrillar basis of clots
reference interval
normal range or range not predictive of disease
normal range
range of values in an analysis that are considered normal. usually encompasses 95% of normal adult values. if distribution of values in population is Gaussian, range is usually set as mean+/- 2 SD
"negativity in health" = likelihood of negative (normal) test result when patient not sick
"positivity in disease" = likelihood of a positive (abnormal) test result if patient is sick
false positive
positive (abnormal) test result when patient is not sick
false negative
negative(normal) test result when patient is truly sick
true positive
positive (abnormal) test result when patient is truly sick
true negative
normal (negative) test result when patient is truly not sick
CK, creatine (phospho)kinase
enzyme found in muscle cells
isoform of CK found predominantly in mycardiocytes
LD or LDH, lactate dehydrogenase
enzyme found in many tissues, including myocardiocytes
form of B-type natriuretic peptide found in myocardiocytes and released on their stress; cleaved to BNP
Receiver Operating Characteristics Curve (ROC Curve)
curve describing ability of test to correctly distinguish health from disease
Positive predictive value
probability (in a given population