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10 Cards in this Set
- Front
- Back
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asthma characterized by?
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Activation of mast cells
Infiltration of eosinophils T helper 2 (TH2) |
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what are 3 chronchoconstrictors mediators?
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Histamine
LeukotrienesD4 Prostaglandin D2 |
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clinical S&S of Asthma?
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Shortness of breath
Chest tightness Wheezing Coughing |
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mediators cause what?
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Bronchoconstriction
Microvascular leakage Plasma exudation |
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pathology of remodeling bronchial mucosa?
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Thickeningof the lamina reticularis
Hyperplasiaof cells of the airway walls this includes the Vessels Smooth muscle Secretory gland Goblet cells |
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Triggers of asthma?
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Respiratory infections
Exercise Medication (ASA) GERD |
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COPD?
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preventable, treatable
persistent airflow limitations This airflow limitations is progressive and associated with chronic inflammatory response Major cause of chronic morbidity and mortality |
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what COPD can lead to?
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small airway fibrosis
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what are the mechanism underlying airflow limitation in COPD?
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Small airways disease
Airway inflammation Airway fibrosis Increased airway resistance Parenchymal destruction Loss of alveolar attachments Decrease of elastic recoil |
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factors that influence disease development and progression?
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cigarette smoking
genetic age and gender (studies indicated women are more susceptible to cigarette smoke than men) Lung growth and development (birth wt and FEV1 in adulthood) |
