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14 Cards in this Set
- Front
- Back
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Adenosine MOA |
Antidysrhythmic used for the tx of paroxysmal SVT. Is a nucleoside that depresses conduction through the AV node. This interrupts re-entry circuits within the heart and may restore SR in pts with SVT. |
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Adenosine INDICATIONS |
Patients 12 yrs and older with SVT and ventricular rate 150/min and over AND - Causing moderate cardiovascular compromise, or - Known to be responsive to Adenosine. |
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Adenosine CONTRAINDICATIONS |
1. Known severe Ax 2. Known sick sinus syndrome, without internal pacemaker in place (may cause severe bradycardia). 3. Previous 2/3° HB without an internal pacemaker in place (may cause HB). 4. Previous heart transplant without an internal pacemaker (following heart transplant the heart is denervated and adenosine may cause bradycardia). |
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Adenosine CAUTIONS |
1. Asthma. May cause bronchospasm and should be withheld if pt has had recurrent life-threatening attacks. 2. COPD. As above. 3. WPW syndrome if the rhythm is possibly fast AF. Could precipitate VF. |
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Adenosine IN PREGNANCY |
Safety not demonstrated. Balance of risk is in favour of administration. |
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Adenosine DOSAGE |
6mg. Second dose of 12mg if rhythm fails to revert. |
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Adenosine ADMINISTRATION |
Undiluted as rapid IV bolus, rapid flush of 20ml NaCl (pref antecubital fossa vein). |
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Adenosine ADVERSE EFFECTS |
1. Bradycardia 2. SOB 3. Light-headed 4. Nausea and flushing 5. Chest pressure and/or severe apprehension |
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Adenosine ONSET |
5-10s |
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Adenosine DURATION |
10-20s |
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Adenosine PHARMACOKINETICS |
Rapidly taken up and metabolised within seconds by the RBCs and vascular endothelial cells. |
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Adenosine PREPARATION |
Ampoule 6mg in 2ml |
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Adenosine COMMON INTERACTIONS |
Dipyridamole** inhibits the cellular uptake of adenosine may cause duration of effect to be prolonged. ** inhibits thrombus formation, rarely prescribed. |
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Adenosine ADDITIONAL INFO |
Usually causes brief period of very low cardiac output, often causing severe apprehension/sense of impending doom. Reassure pt this will pass quickly. Less than 12 yrs, seek clinical advice. |
