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29 Cards in this Set

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Mineralcorticoid effect?

main one?
effect electrolytes of ECF
mainly Na & K

Aldosterone-90%
Glucocorticoid effect?

main one?
effect glucose concentration

Cortisol-90%
Androgens
same effect as testosterone
zonz glomerulosa
outer-15%

Aldosterone

Stimulated by angiotension II/K
zone reticularis
deepest layer

androgens, DHEA, endostrione
small amounts of androgens and estrogens

stimlated by ACTH
zona fasciulata
middle-(widest) 70%

cortisol &
small amount androgens/estrogens

stimulated by ACTH
Aldosterone secretion stimulated by? 2
ECF levels af angiotension II and K.
Cortisol secretion stimulated by?
hypothamic/Pituitary CRH/ACTH
Steroids are made from?....which comes from?
cholesterol comes from LDL'scho
cholesterol pathway
into cell-cleaved at mitochondria by desmolase-progenolone

both ACTH and AGII stimulate the conversion of cholseterol to progenolone
sythetic hormones? potentcy? 3
methypred-x5x potent as cortisol
dexmetasone-30x
predisone-4x
Aldosterone pathway?
cholesterol-progenolone-
progesterone-11-deoxycortisone-
corticosterone-aldosterone
Cortisol pathway?
cholesterol-progenolone-
17 hydrozyprogenolone-
17 hydroxyprogesterone-
11 deoxycortisol-cortisol
has both mineralo/gluco effects? 3
hydrocortisone
predisolone
9-flurocortisol
all adrenocortico hormones are metabolized mainly in the ?
liver
Aldosterone functions?
increased renal reabsorption of Na and secreation of K

-a sodium retainer
Cortisol functions?
2000x greater plasma concentration than aldosterone
Aldosterone deficiency? 3
hyperkalemia
Na/CL wasting
diarhhea
Aldosterone excess?
increased ECF volume
increased BP
little effect of ECF Na
hypokalemia
muscle weakness
loss of H ions (alkalosis)
low sweat/salivation
Aldosterone regulated by? 2
ECF K concentratons, ACII

increased K and angiotension II increases aldosterone secretion.
Cortisol excess symtoms?

caused by?
muscle weakness
moon face
buffalo torso
thin legs
antiinflammatory, lowers permeability
stabilizes lysosomal membrane
causes: stress, trauma, pain,infection, nec-fasc, restraint, catecholamines
Primary Aldosteronism?
Conn's

tumor of zona glomerulosa
Cortisol functions? 6
-stimulates gluconeogenesis
-mobilizes muscle AA's
-allows epi.norepi to utilize glucose
-decreases G utilization by the cells
-increases blood glucose
reduces protien stores and protien synthesis
causes intitial conversion of cholesterol to progenolone?

started by?
protien kinase A

ACTH
CRF regulated by?
cortisol levels

negative feedback
precursor of ACTH?
propiomelanocortin (POMC)
secretes MSH? (melanocye)

affects?
pars intermedia

fur/winter/hibernation
hypoadrenalism?
addision's (cause-autoimmunity)
hyposecretion by the adrenal cortex.

blotchy skin/MM's
hyperadrenalism?
Cushing's
hypersecretion by the adrenal
cortex
-dz-too much ACTH
-syndrome-effects
dexamethasone won't help id there is an ACTH secreting tumor