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29 Cards in this Set
- Front
- Back
Mineralcorticoid effect?
main one? |
effect electrolytes of ECF
mainly Na & K Aldosterone-90% |
|
Glucocorticoid effect?
main one? |
effect glucose concentration
Cortisol-90% |
|
Androgens
|
same effect as testosterone
|
|
zonz glomerulosa
|
outer-15%
Aldosterone Stimulated by angiotension II/K |
|
zone reticularis
|
deepest layer
androgens, DHEA, endostrione small amounts of androgens and estrogens stimlated by ACTH |
|
zona fasciulata
|
middle-(widest) 70%
cortisol & small amount androgens/estrogens stimulated by ACTH |
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Aldosterone secretion stimulated by? 2
|
ECF levels af angiotension II and K.
|
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Cortisol secretion stimulated by?
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hypothamic/Pituitary CRH/ACTH
|
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Steroids are made from?....which comes from?
|
cholesterol comes from LDL'scho
|
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cholesterol pathway
|
into cell-cleaved at mitochondria by desmolase-progenolone
both ACTH and AGII stimulate the conversion of cholseterol to progenolone |
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sythetic hormones? potentcy? 3
|
methypred-x5x potent as cortisol
dexmetasone-30x predisone-4x |
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Aldosterone pathway?
|
cholesterol-progenolone-
progesterone-11-deoxycortisone- corticosterone-aldosterone |
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Cortisol pathway?
|
cholesterol-progenolone-
17 hydrozyprogenolone- 17 hydroxyprogesterone- 11 deoxycortisol-cortisol |
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has both mineralo/gluco effects? 3
|
hydrocortisone
predisolone 9-flurocortisol |
|
all adrenocortico hormones are metabolized mainly in the ?
|
liver
|
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Aldosterone functions?
|
increased renal reabsorption of Na and secreation of K
-a sodium retainer |
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Cortisol functions?
|
2000x greater plasma concentration than aldosterone
|
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Aldosterone deficiency? 3
|
hyperkalemia
Na/CL wasting diarhhea |
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Aldosterone excess?
|
increased ECF volume
increased BP little effect of ECF Na hypokalemia muscle weakness loss of H ions (alkalosis) low sweat/salivation |
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Aldosterone regulated by? 2
|
ECF K concentratons, ACII
increased K and angiotension II increases aldosterone secretion. |
|
Cortisol excess symtoms?
caused by? |
muscle weakness
moon face buffalo torso thin legs antiinflammatory, lowers permeability stabilizes lysosomal membrane causes: stress, trauma, pain,infection, nec-fasc, restraint, catecholamines |
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Primary Aldosteronism?
|
Conn's
tumor of zona glomerulosa |
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Cortisol functions? 6
|
-stimulates gluconeogenesis
-mobilizes muscle AA's -allows epi.norepi to utilize glucose -decreases G utilization by the cells -increases blood glucose reduces protien stores and protien synthesis |
|
causes intitial conversion of cholesterol to progenolone?
started by? |
protien kinase A
ACTH |
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CRF regulated by?
|
cortisol levels
negative feedback |
|
precursor of ACTH?
|
propiomelanocortin (POMC)
|
|
secretes MSH? (melanocye)
affects? |
pars intermedia
fur/winter/hibernation |
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hypoadrenalism?
|
addision's (cause-autoimmunity)
hyposecretion by the adrenal cortex. blotchy skin/MM's |
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hyperadrenalism?
|
Cushing's
hypersecretion by the adrenal cortex -dz-too much ACTH -syndrome-effects dexamethasone won't help id there is an ACTH secreting tumor |