Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
18 Cards in this Set
- Front
- Back
|
2 major thyroid hormones?
3rd hormone? |
thyroxine-t4 93% weakerthe
triiodothyronin-t3N 7% stronger calcitonin |
|
|
effect on BMR?
no thyroid hormones? too much " "? |
none= -40%
too much= +40-60% |
|
|
the functions of t4/t4 are_______ but thier _______ and _______ are different?
|
same functions
different potency and durations |
|
|
thyroid follicular cells?
|
cuboidal epitheilium
|
|
|
iodine requirements?
|
50mg/hr
1 mg/week |
|
|
ioidide trapping in follice?
affected by? |
30-250 times the iodine concentration compared to the blood, last about 2-3 months.
-rate of TSH secretion |
|
|
throglobulin produced by?
how may tyrosines per thyroglobulin? |
ER and Golgi apparatus
70 tyrosines |
|
|
thyroid pathway?
|
TRH-TSH-thyroglobulin-tyrosine/iodide-
-perioxidase- iodinase enzyme-in globulin molecule |
|
|
thyroid release pathway?
|
lysosomes/pinocytosis/proteases
scraps put back in the mix by deiodinase enzyme |
|
|
thyroid protien binding?
|
99%
1/2 of thyroxine(t4) in the blood is released every 6 days. 1/2 t3 released in 1 day |
|
|
thyroid hormone functions? 5
|
-increase transcriptions of large numbers of genes.
-generalized increase in functional activity throughout the body, up BMR. -MRNA translation -protien formation -incrased mitochondria, ATPase, energy |
|
|
effects of Thyroid hormones? 6
|
-stimulate carbohydrate/fat metabolism, glucose uptake
-enhanced glucolysis, gluconeogenesis -increase insulin secretion -increase free FA'S -decrease cholesterol, tri-g's (bile, feces) -insomnia |
|
|
Effects of hypothyroidism? 6
|
-high cholesterol, Tri-g's, phospholipids leads to artheroscloerosis
-lethargic -intolerance to cold -increased weight -low HR, CO -constipation |
|
|
Effects of hyperthyroidism? 7
|
-anxious, nervous, tremor
-intolerance to heat -vitamin deficiency -decreased weight -increased HR, CO, contractility -icreased RR (VE) -diarrhea |
|
|
increase TSH?
decrease TSH? |
-cold
-anxiety, excitement |
|
|
causes of hyperthyroid? 4
|
toxic goiter
thryotoxicosis graves dz thyroid adenomna sx;exopthalmus |
|
|
causes of hypothyroidism 5
sx? |
low iodine
non-toxic goiter perioxidase deficiency deiodinase deficiency turnips/cabbage sx-myxedema, non-pitting |
|
|
extreme hypothyroidism during childhood?
|
cretinism
|
