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18 Cards in this Set

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2 major thyroid hormones?

3rd hormone?
thyroxine-t4 93% weakerthe

triiodothyronin-t3N 7% stronger

calcitonin
effect on BMR?

no thyroid hormones?
too much " "?
none= -40%

too much= +40-60%
the functions of t4/t4 are_______ but thier _______ and _______ are different?
same functions

different potency and durations
thyroid follicular cells?
cuboidal epitheilium
iodine requirements?
50mg/hr

1 mg/week
ioidide trapping in follice?

affected by?
30-250 times the iodine concentration compared to the blood, last about 2-3 months.

-rate of TSH secretion
throglobulin produced by?

how may tyrosines per thyroglobulin?
ER and Golgi apparatus

70 tyrosines
thyroid pathway?
TRH-TSH-thyroglobulin-tyrosine/iodide-
-perioxidase-

iodinase enzyme-in globulin molecule
thyroid release pathway?
lysosomes/pinocytosis/proteases

scraps put back in the mix by
deiodinase enzyme
thyroid protien binding?
99%
1/2 of thyroxine(t4) in the blood is released every 6 days.

1/2 t3 released in 1 day
thyroid hormone functions? 5
-increase transcriptions of large numbers of genes.
-generalized increase in functional activity throughout the body, up BMR.
-MRNA translation
-protien formation
-incrased mitochondria, ATPase, energy
effects of Thyroid hormones? 6
-stimulate carbohydrate/fat metabolism, glucose uptake
-enhanced glucolysis, gluconeogenesis
-increase insulin secretion
-increase free FA'S
-decrease cholesterol, tri-g's (bile, feces)
-insomnia
Effects of hypothyroidism? 6
-high cholesterol, Tri-g's, phospholipids leads to artheroscloerosis
-lethargic
-intolerance to cold
-increased weight
-low HR, CO
-constipation
Effects of hyperthyroidism? 7
-anxious, nervous, tremor
-intolerance to heat
-vitamin deficiency
-decreased weight
-increased HR, CO, contractility
-icreased RR (VE)
-diarrhea
increase TSH?

decrease TSH?
-cold

-anxiety, excitement
causes of hyperthyroid? 4
toxic goiter
thryotoxicosis
graves dz
thyroid adenomna
sx;exopthalmus
causes of hypothyroidism 5
sx?
low iodine
non-toxic goiter
perioxidase deficiency
deiodinase deficiency
turnips/cabbage

sx-myxedema, non-pitting
extreme hypothyroidism during childhood?
cretinism