Western Pharmacology Ocom

Front 1

Sympathetic Post-ganglionic

Back 1

•Release Norepinephrine
•Stimulate alpha and beta receptors
•Metabolized by MAO & COMT ( enzymes responsible for breaking down)

Front 2

Parasympathetic Post-ganglionic

Back 2

•Release Acetylcholine
•Stimulate muscarinic receptors
•Metabolized by cholinesterase

Front 3

Pharmacology is the study of drugs and can be divided into two sub-sciences?

Back 3

•Pharmacodynamics: what drugs do to the body
•Pharmacokinetics: what the body does to drugs and how fast it does it (e.g. absorption, distribution, metabolism, excretion)

Front 4

Pharmacotherapeutics: Treatment of disease by drugs

Back 4

•Palliative (most drugs)
•Curative (some drugs)

Front 5

Drug absorption (passage of drug from site of administration into bloodstream) and
Drug distribution (passage of drug from bloodstream to site of action)
are determined by?

Back 5

a)Drug molecular size
b)Drug solubility
c)Conditions at site of tissues to be penetrated by drug

Front 6

Alpha 1 antagonist stimulates what of the iris?

Back 6

Alpha 1 antagonist stimulation of radial muscle of iris causes mydriasis

Front 7

Alpha 1 antagonist stimulates arterioles causing?

Back 7

Alpha 1 antagonist stimulation of arterioles causes vasoconstriction.

Front 8

Beta 1 & 2 antagonist stimulate?

Back 8

Beta 1 & 2 antagonist stimulation of heart causes + inotropic and + chronotropic response.

( increase heart rate, increase BP)

Front 9

Beta 2 antagonist stimulates?

Back 9

Beta 2 stimulation of bronchus causes bronchodilation.

Front 10

Epinephrine - category?

Back 10

Ans- sympathetic

Front 11

Epinephrine MOAction?

Back 11

Alpha and beta antagonist

Front 12

Epinephrine district characteristics ?

Back 12

Ineffective orally
Sort half life

Front 13

Epinephrine actions or uses ?

Back 13

Positive inotrophic & chronotrophic
Bronchodilator
Like local anesthesia

Front 14

Phenylephrine category?

Back 14

ANS sympathomimetic

Front 15

Phenylephrine MOA ?

Back 15

Alpha 1 antagonist

Front 16

Phenylephrine distinct characteristics ?

Back 16

Effective orally
Limiters CNS access

Front 17

Phenylephrine actions and uses ?

Back 17

Nasal congestion
CNS stimulation

Front 18

Isoproterenol category?

Back 18

ANS sympathy mimetic

Front 19

Isoproterenol MOA?

Back 19

Beta 1&2 antagonist

Front 20

Isoproterenol distinct characteristics?

Back 20

Metabolized by COMT
Shirt duration of action

Front 21

Pseudoephedrine category?

Back 21

ANS Symapathomimetric

Front 22

Pseudoephedrine MOA?

Back 22

Indirect acting

Front 23

Pseudoephedrine distinct characteristics?

Back 23

Crosses blood brain barrier
Effective orally

Front 24

Pseudoephedrine actions & uses ?

Back 24

Nasal congestion
CNS stimulation

Front 25

Albuterol category?

Back 25

ANS Symapathomimetic

Front 26

Albuterol MOA?

Back 26

Beta 2 antagonist

Front 27

Albuterol distinct characteristics ?

Back 27

Several hour duration of action

Front 28

Albuterol actions and uses?

Back 28

Bronchodialator
Limited cardiac effect
Selective vasodilation

Front 29

Clonodine category?

Back 29

ANS Sympathomimetric
Anti hypertensive

Front 30

Clonodine MOA?

Back 30

Alpha 2 antagonist

Front 31

Clonodine distinctive characteristics?

Back 31

Effective orally
Crosses blood brain barrier
CNS Alpha preference
Long half life

Front 32

Clonodine actions & uses ?

Back 32

Centrally acting anti hypertensive
Dry mouth
Sedation
Sexual dysfunction

Front 33

Acetylcholine category ?

Back 33

•Category: ANS- Parasympathomimetic

Front 34

Acetylcholine MOA?

Back 34

•MOA: Muscarinic and nicotinic agonist

Front 35

Acetylcholine Distinguishing characteristics

Back 35

–Rapidly hydrolyzed by esterases
–Acts on both muscarinic and nicotinic receptors
–Quaternary ammonium group invokes polarity

Front 36

Acetylcholine characteristics

Back 36

–Short half life (seconds)
–Diffuse activity (parasympathomimetic, sympathomimetic and skeletal muscle)
–Limited distribution

Front 37

Acetylcholine actions and uses ?

Back 37

•Predictable uses: Possible local ophthalmic use, but other products better.

Front 38

Phenelzine category?

Back 38

ANS Sympathomimetic

Front 39

Phenelzine MOA ?

Back 39

MAO inhibitor

Front 40

Phenelzine characteristics?

Back 40

Crosse blood brain barrier
Readily absorbed

Front 41

Phenelzine actions and uses?

Back 41

Increased catecholamine levels
Used as antidepressant
Interacts with symathomimetrics

Front 42

Reserpine category ?

Back 42

ANS sympatholytic

Front 43

Reserpine MOA ?

Back 43

Norepinephrine depletor

Front 44

Reserpine characteristics ?

Back 44

Anti quated

Front 45

Reserpine actions and uses ?

Back 45

Decreases blood pressure
Effects exceeds presence
Initial sympathommimmeffect

Front 46

Prazocin category ?

Back 46

ANS sympatholytic and anti hypertensive

Front 47

Prazocin MOA?

Back 47

Alpha 1antagonnist

Front 48

Prazocin characteristics ?

Back 48

Highly protein bound
Effective orally
Limited reflex tachycardia

Front 49

Prazocin actions and uses?

Back 49

Diminish peripheral resistance
May cause syncope
Mitosis

Front 50

Propranolol category ?

Back 50

ANS sympatholytic
Anti hypertensive
Anti arrhythmic
Antianginal

Front 51

Propranolol MOA?

Back 51

Beta 1&2 antagonist

Front 52

Propranolol characteristics ?

Back 52

1 st pass metabolism
Highly lipid soluble

Front 53

Propranolol actions and uses ?

Back 53

Antiarrytymic
Antianginal
Risk to asthmatics
Risk to diabetes

Front 54

Metoprolol category ?

Back 54

ANS sympatholytic
Anti hypertensive

Front 55

Metoprolol MOA?

Back 55

Beta 1 antagonist

Front 56

Metoprolol characteristics ?

Back 56

1 st pass metabolism
Highly lipid soluble

Front 57

Metoprolol actions and uses ?

Back 57

Negative inotropic and chronotropic
Limited asthmatic & diabetic risk