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12 Cards in this Set

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complications in wound healing?
-deficient scar formation
-excessive formation of repair components: keloid scars
-formation of contractures - exaggerated contraction of wound
systemic factors retarding wound healing
-nutrition: vitamin c
-metabolic status: diabetes
-circulatory status: retarded venous drainage
-hormones: glucocorticoids (inhibit collagen syn)
local factors retarding wound healing
-infection
-mechanical
-foreign bodies
-size/location/type
first intention
-clean, uninfected surgical incision
-re-epithelialization to close wound
-thin scar
second intention
-wound creates large defect on skin
-big loss cells/tissue
-large scar
Inflammation: involves? time?
-RBC + fibronectin + fibrin + complement components
-w/in 24 hrs
granulation
-24-72 hrs into
-angiogenesis/proliferation of fibroblasts form gran tissue
-more granulation tissue w/more intensity of wound/inflammation
wound contraction
-w/large surface wounds
-myofibroblasts express smooth muscl alpha-actin
-contract wound tissue
fibroblast migration
-driven by chemokines/cytokines
-48-96 hrs in
epithelialization
-close wound from dermis outward
-collagen fibrils bridge incision
fibrosis
-excessive deposit of collagen/other ECM
-usually in chronic disease
wound strength
-dependent on net collagen accumulation
-more tensile strength after 2 months + cross-linking