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18 Cards in this Set
- Front
- Back
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Osteoblasts cause bone _________. |
formation osteoblast = build |
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Osteoclasts cause bone __________. |
reabsorption osteoclast = consume |
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Osteoblasts are stimulated by |
Stress Oestrogen Hormone |
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Osteoclasts are stimulated by __________ and inhibited by ___________. |
Low plasma calcium levels Testosterone |
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Parathyroid hormone increases the _______ level of__________ |
plasma
calcium |
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Hormonal regulation ofplasma Ca2+ levels |
Parathyroid glands increase secretion of parathyroid hormone |
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Parathyroid glands increase secretion of parathyroid hormone -> ________ removed from ________ to the bloodstream - > plasma calcium levels increase again |
calcium bone |
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Parathyroid glands increase secretion of parathyroid hormone -> ______ excretion by________ reduced - > plasma calcium levels increase again |
Calcium Kidney |
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Parathyroid glands increase secretion of parathyroid hormone -> _______ productionincreased - > More calcium absorbed by __ - > plasma calcium levels increase again |
Vitamin D gut |
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What are the requirements for bone health |
Adequate dietary calcium Adequate Vitamin D Adequate weight-bearing exercise |
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Bone disorders include |
Post-menopausal osteoporosis Paget’s disease of bone (osteitis deformans)9 |
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Bisphosphonates include |
Etidronate Alendronate Zoledronic acid |
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Bisphosphonates inhibit bone resorption by ? |
being incorporated into bone, and inhibiting osteoclasts. |
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Bisphosphonates are used for ??? |
paget’s disease osteoporosis bone metastasis osteogenesis imperfecta crews on long space missions |
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Problems with bisphosphonates include _____________ therefore must be taken on empty stomach. |
poor oral absorption |
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Problems with bisphosphonates include irritating to ____________ therefore? |
oesophagus need to remain upright for½ hour after taking them |
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no _______,_________ or other __________ within ___ hours of taking bisphosphonates |
antacids calcium minerals 2hours |
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Bisphosphonates have rare but serious side effect is __________, which is more likely if ? |
necrosis of the jaw there is trauma (accidental or due to dental procedures) |
