Week 6 Micro- Viruses Plfsom

Front 1

What is a strain

Back 1

species of the same virus with different nucleotide sequence

Front 2

What are the most common forms of viral genomes

Back 2

ssRNA and dsDNA

Front 3

Are all types of genomes medically important?

Back 3

Yes

Front 4

viral ssRNA are subdivided into _______ and _________ polarity

Back 4

positive and negative

Front 5

what is negative polarity?

Back 5

antisense (cannot be used as a direct template for protein synthesis)

Front 6

what is positive polarity?

Back 6

sense (it can be used as protein template)

Front 7

How is polarity commonly referred to/

Back 7

positive-strand and negative-strand RNA viruses

Front 8

What are the 2 types of capsid symmetry?

Back 8

helical or icosahedral

Front 9

What is the capsid constructed of?

Back 9

multiple copies of a single polypeptide (helical), a small number of different polypeptides (icosahedral)

Front 10

How are polypeptide units (protomers) bound to neighboring protomers?

Back 10

H-bonding

Front 11

What is called the nucleocapsid?

Back 11

the complex of protomers and nucleic acid

Front 12

How is the nucleic acid of a virus protected from its environment?

Back 12

by being surrounded by the capsid

Front 13

what is a capsomer?

Back 13

structural subassemblies of icosahedral capsids

Front 14

T/F. An important structural feature used in defining a viral family is the presence or absence of a lipi-containing membranse surrounding the nuclepcapsid.

Back 14

TRUE

Front 15

A virus that is not enveloped is referred to as a

Back 15

naked virus

Front 16

All of the helical viruses of animals are ________

Back 16

enveloped and contain RNA

Front 17

Eclipse period

Back 17

represent the time elapsed from initial entry and disassembly of the parental virus to the assembly of the first progeny virion.

Front 18

Is active synthesis of virus components occuring during the eclipse period?

Back 18

Yes

Front 19

Exponential growth

Back 19

incrase of progeny increases exponentially for a time, then reaches a plateau, after which no additional progency yield occurs.

Front 20

What is the growth limit of a virus within a cell limited to?

Back 20

the rate at which the cell loses the synthetic capacity and structural integrity needed to produce new virus particles

Front 21

Steps in the replication cycles of viruses

Back 21

Adsoprtion, penetration, Uncoating, genome replication, assembly and release of progeny viruses,

Front 22

Influenza Family

Back 22

Orthomyxoviridae

Front 23

Influenza Genome

Back 23

ss (-) RNA segmented

Front 24

Influenza Morphology

Back 24

enveloped, helical

Front 25

Influenza Receptor

Back 25

sialic acid

Front 26

Parainfluenza Family

Back 26

paramyxoviridae, subfamily paramyxovirinae

Front 27

parainfluenza Genome

Back 27

ss (-) RNA, no segments

Front 28

Parainfluenza Morphology

Back 28

helical

Front 29

Parainfluenza Receptor

Back 29

sialic acid

Front 31

Coxsackie A Family

Back 31

Picornaviridae

Front 32

Coxsackie A Genome

Back 32

ss(+) RNA

Front 33

Coxsackie A Morphology

Back 33

No envelope, icosahedral

Front 34

Coxsackie A Receptor

Back 34

Icam-1, or LDL

Front 35

Rhinovirus Family

Back 35

Picornaviridae

Front 36

Rhino Virus Morphology

Back 36

ss(+) RNA

Front 37

Rhinovirus Receptor

Back 37

No envelope, icosahedral

Front 38

Coronavirus Family

Back 38

Coronaviridae

Front 39

Coronavirus Genome

Back 39

ss(+) RNA

Front 40

Coronavirus Morphology

Back 40

Enveloped, helical

Front 41

Coronavirus Receptor

Back 41

variety of glycoproteins

Front 42

CMV, Herpes, EBV Family

Back 42

Herpesviridae

Front 43

CMV, Herpes, EBV Genome

Back 43

dsDNA

Front 44

CMV, Herpes, EBV Morphology

Back 44

Enveloped, icosahedral

Front 45

CMV, Herpes, EBV Receptor

Back 45

Heparin sulfate a Nectin 1

Front 46

HIV (acute phase) Family

Back 46

Retroviridae

Front 47

HIV ac genome

Back 47

RNA

Front 48

HIV ac Morphology

Back 48

enveloped

Front 49

HIV ac Receptor

Back 49

CD4 & CCR5 or CXCR4

Front 50

Can you get an earache with rhinovirus?

Back 50

Yes

Front 51

Is parainfluenza lytic?

Back 51

No, it buds

Front 52

parainfluenza transmission

Back 52

Spread by droplets

Front 53

What is influenzas interaction with the hose

Back 53

non-lytic but cytopathic. Antigenic drift and shift allow the virus to avoid immunity and can result in pandemics. Buds from apical surface of respiratory cells (non-lytic)

Front 54

Transmission of influenza

Back 54

mostly respiratory secretions

Front 55

influenza characteristics

Back 55

8 hour onset, super high fever

Front 56

rhinovirus disease

Back 56

rhinitis/sore throat, common cold, afebrile

Front 57

rhinovirus interaction with host

Back 57

lytic

Front 58

host cell rrange

Back 58

highly species specific

Front 59

Transmission of rhinovirus

Back 59

direct contact, nasal secretions, fomites more important than aerosols

Front 60

why are picornivaviridae fecal-oral?

Back 60

acid stable, can live through digestion

Front 61

rhinovirus interaction with host

Back 61

lytic

Front 62

rhinovirus host cell range

Back 62

highly species specific

Front 63

rhinovirus transmission

Back 63

direct contact, nasal secretions, fomites more important than aerosols

Front 64

What is the big difference between influenza and rhinovirus

Back 64

translation timing

Front 65

M1 in infleuza

Front 66

M2 in influenza

Front 67

Is rhinovirus released by budding?

Back 67

NO, its not envelloped

Front 68

be able to describe + and - and enveloped vs non enveloped

Front 69

Tamaflu

Back 69

blocks nerominidase- blocks the release of the virus from the cell