Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
36 Cards in this Set
- Front
- Back
|
About how many amino acids is each Ig domain composed of?
|
110
|
|
|
How are Ig domains held together?
|
by internal disulfide bonds
|
|
|
What are Ig domains composed of?
|
two players of B-pleated sheets
|
|
|
True or False? TRC's and BRC's both have variable (V) and constant (C) regions
|
true
|
|
|
True or False? Variable(V) regions are not very diverse.
|
false
|
|
|
How are TRC's activated?
|
TCR associates with: CD3 and z (zeta) chain (both have ITAMs)
|
|
|
How are BRC's activated?
|
BCR associates with: Iga and Igb (both have ITAMs)
|
|
|
What do BCR's bind?
|
macrocolecules(whole antigens)
|
|
|
What do TCR's bind?
|
peptides displayed by the MHC
|
|
|
Do B cells or T cells secrete their cell receptors?
|
B-Cells(antibodies)
|
|
|
What does the BCRV region bind?
|
linear or conformational determinants on antigen
|
|
|
What does the TCRV region bind?
|
only binds linear peptides in MHC
|
|
|
Does BCRV or TCRV undergo affinty maturation?
|
BCRV
|
|
|
What are the variable regions of BCR and TCR formed by?
|
somatic recombination of gene segments on the same chromosome
|
|
|
What are VDJ segments formed by?
|
recombination of the variable region of BCR heavy chain, and TCR b chain
|
|
|
How are VJ segments formed?
|
recombination of variable region of the BCR light chain, and TCR a chain
|
|
|
What is the most diverse regions of heavy and light chains of an antibody called?
|
complementarity determining regions (CDRs)
|
|
|
Why are many rearrangements non productive?
|
because they create stop codons
|
|
|
How many chains does each antibody molecule have?
|
4(2 heavy and 2 light)
|
|
|
How many fab fragments does each antibody monomer have?
|
2
|
|
|
Each Fab fragment has one
antigen-binding site composed of what? |
variable region of one heavy and one light chain
|
|
|
Each antibody monomer contains one Fc fragment composed of what?
|
heavy chain constant regions
|
|
|
What is allelic exclusion?
|
Each B cell stops rearranging after productively rearranging one heavy chain and one light chain gene
|
|
|
True or False? Each antigen-binding site on an antibody molecule is identical (each site binds same antigen)
|
True
|
|
|
What determines an isotype(antibody class)?
|
the type of constant regions on the heavy chain
|
|
|
Define avidity
|
Cumulative strength of all the antigen-binding sites on an antibody molecule
|
|
|
Define affinity
|
Strength of interaction between an antigen-binding site and an antigen
|
|
|
Which is normaly the first antibody produced in responses?
|
IgM(the first antibody produced has low affinity for the antigen)
|
|
|
What is the normal serum level and half life for IgA?
|
3.5mg/ml and 6 days
|
|
|
What is the normal serum level and half life for IgG?
|
13.5mg/ml 23 days
|
|
|
What is the normal serum level and half life for IgM?
|
1.5mg/ml and 5 days
|
|
|
How does IgM compensate for its lack of affinity?
|
its is a pentamer, therefore it has 10 binding sites making it have a high avidity
|
|
|
Define Epitope or antigenic determinant
|
the exact part of the antigen that binds to the antibody
|
|
|
Define Immunogen
|
an antigen that is capable of producing an immune response
|
|
|
True or False? IgA is usually dimeric
|
True
|
|
|
Which isotypes activate the classical complement pathway?
|
IgG and IgM
|
