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13 Cards in this Set

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Acute lung injury may be cause by pulm. or extrapulm. causes.
True
What is ARDS?
Diffuse pulm. injury,characterised by rapidly progressive:-
-reduced lung volumes
-reduced compliance
-refractory hypoxemia
-dyspnoea
-tachypnoea
When does ARDS occur?
Within 24-48 hrs of the precipitating lung injury.
In ARDS,epithelium and endothelium are both usually damaged.
True
Inhalational injury causes damage to
Air/epithelial interface
Septic shock causes damage to
Blood capillary surface.
What is the role of inflammation in ARDS?
It may be a precipitant(like in SIRS) or consequence of the injury(epithelial injury following gastric acid secretion)-always worsen condition.
In sepsis,lung injury is not that important in the multiple organ failure that may cause death.
False.It is critically important.
Neutrophils may be primed by
-TNFaplha
-GM-CSF
-G-CSF
-endotoxin
Neutrophils may be activated by
-PAF
-LTB4
-phagocytic stimuli
What are the leukocyte responses?
-Superoxide anion generation(tissue/macromolecule damage)
-Myeloperoxidase release
-Glycosidases/proteases(ECM breakdown)
-LTB4 and PAF(further leukocyte recruitment and macrophage activation)
For how long do neutrophils generally survive in the a/w?
less than 24 hrs.
What are neutrophils numbers dictated by?
1.Rates of recruitment due to levels of chemoattractants and level of activation of endothelium.
2.Rates of apoptosis via G-CSF and GM-CSF