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13 Cards in this Set

  • Front
  • Back
Acute lung injury may be cause by pulm. or extrapulm. causes.
What is ARDS?
Diffuse pulm. injury,characterised by rapidly progressive:-
-reduced lung volumes
-reduced compliance
-refractory hypoxemia
When does ARDS occur?
Within 24-48 hrs of the precipitating lung injury.
In ARDS,epithelium and endothelium are both usually damaged.
Inhalational injury causes damage to
Air/epithelial interface
Septic shock causes damage to
Blood capillary surface.
What is the role of inflammation in ARDS?
It may be a precipitant(like in SIRS) or consequence of the injury(epithelial injury following gastric acid secretion)-always worsen condition.
In sepsis,lung injury is not that important in the multiple organ failure that may cause death.
False.It is critically important.
Neutrophils may be primed by
Neutrophils may be activated by
-phagocytic stimuli
What are the leukocyte responses?
-Superoxide anion generation(tissue/macromolecule damage)
-Myeloperoxidase release
-Glycosidases/proteases(ECM breakdown)
-LTB4 and PAF(further leukocyte recruitment and macrophage activation)
For how long do neutrophils generally survive in the a/w?
less than 24 hrs.
What are neutrophils numbers dictated by?
1.Rates of recruitment due to levels of chemoattractants and level of activation of endothelium.
2.Rates of apoptosis via G-CSF and GM-CSF