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13 Cards in this Set
- Front
- Back
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Acute lung injury may be cause by pulm. or extrapulm. causes.
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True
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What is ARDS?
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Diffuse pulm. injury,characterised by rapidly progressive:-
-reduced lung volumes -reduced compliance -refractory hypoxemia -dyspnoea -tachypnoea |
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When does ARDS occur?
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Within 24-48 hrs of the precipitating lung injury.
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In ARDS,epithelium and endothelium are both usually damaged.
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True
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Inhalational injury causes damage to
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Air/epithelial interface
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Septic shock causes damage to
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Blood capillary surface.
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What is the role of inflammation in ARDS?
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It may be a precipitant(like in SIRS) or consequence of the injury(epithelial injury following gastric acid secretion)-always worsen condition.
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In sepsis,lung injury is not that important in the multiple organ failure that may cause death.
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False.It is critically important.
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Neutrophils may be primed by
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-TNFaplha
-GM-CSF -G-CSF -endotoxin |
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Neutrophils may be activated by
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-PAF
-LTB4 -phagocytic stimuli |
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What are the leukocyte responses?
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-Superoxide anion generation(tissue/macromolecule damage)
-Myeloperoxidase release -Glycosidases/proteases(ECM breakdown) -LTB4 and PAF(further leukocyte recruitment and macrophage activation) |
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For how long do neutrophils generally survive in the a/w?
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less than 24 hrs.
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What are neutrophils numbers dictated by?
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1.Rates of recruitment due to levels of chemoattractants and level of activation of endothelium.
2.Rates of apoptosis via G-CSF and GM-CSF |
