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6 Cards in this Set
- Front
- Back
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Characteristics of P. aeruginosa
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- gram negative bacillus
- highly motile with polar flagella - fluorescent under UV light and has colored pigments - smells like grapes or corn chips to some people - ubiquitous in environemtn and can survive on pretty much anything |
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What are two differenes between P. aeruginosa and enterobacteriaceae?
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- P aeruginosa is lactose negative on MacConkey and Oxidase +
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Why is p. aeruginosa considered to have intrinsic antibiotic resistance?
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The cell wall and outer membrane are "impervious" to antibiotics
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Diseases caused by p. aeruginosa
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- UTIs
- wound infections - sepsis - pneumonia - endocarditis (particularly in immunocompromised patients) - requires a breach in the immune system |
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What is the relationship between P. aeruginosa and CF?
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- CF lung selects for P. aeruginosa with increased alginate and decreased digestive enzymes
- leads to chronic inflammation and damage - not a good mucociliary removal of bacteria * PA will preferentially bind to damaged epithelial tissue! |
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Virulence factors of P. aeruginosa
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- pili (adherence)
- flagella (spread) - toxins (like LPS) for damage / nutrient acquisition - Exotoxin A - type III secretion system - capsule (undergoes phase variation) |
