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5 Cards in this Set

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Acute Lymphoblastic Leukemia/Lymphoma
(Precursor B and T cell Neoplasm)
Mostly of B cell origin
PAS positive
TdT - a specialized DNA polymerase used for detection as it is only on pre-B abd T lymphoblasts
Pre-B have CD19
Pre-T have CD1A
Philadelphia Chromosome t(9,22) common cause
Acute Lymphoblastic Leukemia/Lymphoma Symptoms
Abrupt onset
Fatigue due to anemia
Bleeding due to dec. plateletes
Bone Pain and tenderness due to marrow expansion
Chronic Lyphocytic Leukemia (CLL) and Small Lymphocytic Lymphoma (SLL)
Dividing cells aggregate in proliferation centers

Smudge Cells are seen in CLL which are small lymphocytes that are disrupted

CD19 and CD20

Late onset 50 years and more common in men
Follicular Lymphoma
Most common of NHL

t(14;18) and is due to BCL@ increase
Diffuse Large B-Cell Lymphoma
(DLBCL)
Show a relatively large