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38 Cards in this Set
- Front
- Back
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CD45
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ALL WBC
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CD34
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blood precursor
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CD30
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Reed-Sternberg
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CD10
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Burkitt/follicular lymphoma & lymphoblastic leukemia
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TdT
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nuclear deoxynucleotidyl transferase: B & T lymphoblasts
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ClclinD1 (bcl1)
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Mantle cell lymphoma
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CD3
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Pan-T cell
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CD5
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Pan T cell (and B-cell CLL)
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CD4
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helper T
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CD8
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suppressor/cytotoxic T
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CD19
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B cell
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CD20
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B cell
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CD14
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Monocyte
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CD15
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myeloid
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CD33
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meloid/monocyte; mature granulocyte
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CD19, CD34, TdT
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B lymphoblast
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CD3, CD34, TdT
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T lymphoblast
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CD33, CD14
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monocyte
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CD3, CD8
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mature T cell
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CD34, CD33
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myeloblast (because precursor 34)
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only place with co-expression of CD8/CD4
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upper right quadrant: THYMUS
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Neoplastic Langerhans histiocytes
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-nuclear grooving
-S100 antigen |
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3 forms of langerhans histiocytes
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1. eosinophilic granuloma
2. hand-schuler-christian Dz 3. lettetrer-Siwe Dz |
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Usually in adults, solitary bone lesion. Pretty benign
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Eosinophilic granuloma
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Mostly in kids, multifocal lesions; especially at base of skull. Can get diabetes insipidus if pituitary or calvarium is involved.
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Hand-Schuler Christian
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Mostly in infants. MALIGNANT! disseminated; multi system involvement.
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Letterer-Siwe Dz
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Neutrophils/Monocytes that aren't neoplastic -but genetically impaired
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1. Chronic granulomatous Dz
2. Chediak-Higashi Syndrome 3. Myeloperoxidase Deficiency 4. May-Hegglin Anomaly 5. Leukocyte Adhesion molecule deficiency (CD11/CD18) |
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can't generate burst because no NADPH. Kills Strep, but not Staph
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Chronic granulomatous X-linked
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normal looking neutrophils, negative NBT stain, recurent infections/absecces
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Chronic granulomatous X-linked
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abnormal giant lysosomes, with neutropenia and long bleeding time
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Chediak-Higashi Syndrome
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Impaired chemotaxis, degranulation and bactericidal activity
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Neutropenia in Chediak-Higashi
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Can make H202, but not Halide
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Myeloperoxidase Deficiency
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Increased risk of candida infections in DB
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myeloperoxidase deficiency
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no increasd risk of bacterial infections
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myeloperoxidase deficiency & May-Hegglin
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why do you have an positive NBT test with myeloperoxidase deficiency?
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because still making H202, just can't make halide
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thrombocytopenia, bizzare looking plateles, giant Dohle bodies
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May-Hegglin Anomaly
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reccurent infections, neutrophilia (because can't marginate), delayed wound healing & umbilical cord separation
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CD11/CD18 deficiency
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abnormal adhesion, chemotaxis, oxidative burst, degranulation
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CD11/18 deficiency
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