Wbc

Front 1

Nuclear abnormality:

Back 1

Hypersegmented neutrophil

Hint 1

More than 5 lobes

Problem: DNA synthesis

Vitamin b12 and folate deficiency

Pernicious anemia

Megaloblastic andmia

Front 2

Nuclear abnormality:

Back 2

Pegler-Huet Anomaly

Hint 2

Hyposegmented neutrophil

Nucleus: dumbbell, pair of glasses, spectacle, peanut

Benign anomaly

Acquired-autosomal dominant disorder

Front 3

Nuclear abnormality:

Back 3

Barr Body/ Sex-Chromatin bodies

Hint 3

Small round projection of nuclear chromatin

2nd X chromosome of females (<20% of females)

2-3% female

Front 4

Nuclear abnormality:

Back 4

Giant Neutrophil

Hint 4

Larger

Occasionally seen in normal peripheral circulation

Often observed in hypersegmented neutrophils

Front 5

Cytoplasmic abnormality:

Back 5

Alder-reilly inclusions

Hint 5

Granules: Purple-red, precipitated mucopolysaccharides

Found in:

1. granulocytes

2.monocytes/lymphocytes

Larger than toxic granulation

Test: CTAB --- (+) white turbidity

-Hurler's and Hunter's syndrome

Front 6

Cytoplasmic abnormality:

Back 6

Auer rods

Hint 6

Reddish-purple, rod-like bodies

Represents: primary granules

Test: peroxidase

Normal: low number

Abnormal: high number

-Acute myelogenous leukemia

Front 7

Cytoplasmic abnormality:

Back 7

Chediak-Higashi granules

Hint 7

Impaired chemotaxis

Granules: large reddish-purple

Lysosomal granules

test: peroxidase, sudan black B

-Hereditary disease (autosomal recessive)

Front 8

Cytoplasmic abnormality:

Back 8

Dohle bodies/Amato bodies

Hint 8

Single/multiple at periphery of cytoplasm

1. Neutrophil

2. Monocytes/Lymphocytes

Wright stain: light blue

Represents: aggregation of RER

-Burns, viral infxn, certain drug therapy

Front 9

Cytoplasmic abnormality:

Back 9

Toxic granulation

Hint 9

Granules: dark blue-black

RNA precipitation

Test: peroxidase

Seen in: band & segmented neutrophils

-burns, drugs therapy/poisoning

Front 10

Cytoplasmic abnormality:

Back 10

Jordan's anomaly/ Toxic vacuolation

Hint 10

Vacuolation in phagocytes (granulocytes, monocytes)

Aging and active phagocytosis

Increased lysosomal activity - fatty degeneration & glycogen

-septicemia, severe infxn

Front 11

Cytoplasmic abnormality:

Back 11

May-hegglin anomaly

Hint 11

Platelets and granulocyte anomaly

With dohle like inclusion granulocytes

-giant platelets, thrombocytopenia

Front 12

Phagocytes abnormality:

Back 12

LE cells

Hint 12

NEUTROPHIL w/ large purple homogenous round inclusion w/ nucleus wrapped around

Smooth and evenly stained

-Lupus eythematosus (autoimmune)

Front 13

Phagocytes abnormality:

Back 13

Tart cells

Hint 13

MONOCYTES with ingested lymphocyte

Rough and unevenly stained

Front 14

Lymphocyte abnormality:

Back 14

Downey cells/Atypical lymphocytes

(Reactive/Variant/Transformed lymphocytes, Leukocytoid)

Hint 14

Type 1: Turk's irritation cells/plasmacytoid lymphocytes with large block chromatin

Type 2: Infectious Mononucleosis (ballerina skirt appearance)

Type 3: (swiss cheese/moth-eaten appearance)

Front 15

Lymphocyte abnormality:

Back 15

Basket cell/smudge cell

Hint 15

Squashed degenerative nuclei

-chronic lymphocytic leukemia

Front 16

Lymphocyte abnormality:

Back 16

Hairy cells

Hint 16

B- lymphocyte with hair-like cytoplasmic projections

Test: TRAP

-Hairy cell leukemia

Front 17

Lymphocyte abnormality:

Back 17

Sezary cells

Hint 17

Have T cell characteristics

Grooved nucleus

Brain-like convolutions (cerebri form)

-sezary syndrome, mycosis fungiodes, cutaneous T cell lymphoma

Front 18

Plasma abnormality:

Back 18

Flame cell

Hint 18

Red to pink cytoplasm

Increased IgA

-multiple myeloma

Front 19

Plasma abnormality:

Back 19

Russell antibodies

Hint 19

Individual globules of Igs

-multiple myeloma, reactive state

Front 20

Plasma abnormality:

Back 20

Morula cell/Molt cell/Grape cell/Berry cell

Hint 20

Vacuoles and large protein globules

Grape-like

-multiple myeloma, reactive state

Front 21

Plasma abnormality:

Back 21

Dutcher's bodies

Hint 21

Intranuclear inclusions

Front 22

Back 22

1. Neutrophil

2. Monocytes

3. Lymphocyte

4. Erythrocyte

5. Platelet

6. Eosinophil

7. Neutrophil

8. Basophil

Front 23

Back 23

Front 24

Back 24

Front 25

Back 25

Front 26

Back 26

Hypersegmented neutrophil

Front 27

Back 27

Pegler-Huet anomaly (dumbbell)

Front 28

Back 28

Pseudo Pegler-Huet (round)

Front 29

Back 29

Alder-reilly inclusions

Front 30

Back 30

Chediak-Higashi granules

Front 31

Back 31

Dohle bodies

Front 32

Back 32

Toxic granulation

Front 33

Back 33

May-Hegglin anomaly

Hint 33

Abnormally Large platelet

Front 34

Back 34

Basket cell/Smudge cell

Front 35

Back 35

Downey cell/atypical lymphocyte

Front 36

Back 36

Hairy cell

Front 37

Back 37

Sezary cell

Front 38

Back 38

Flame cell

Front 39

Back 39

Russel bodies

Front 40

Back 40

Grape/Berry/Morula/Molt cell

Front 41

Back 41

Dutcher's bodies