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15 Cards in this Set
- Front
- Back
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Functional Anemia
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decreased capacity for oxygen delivery
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Fetal Erythrocytes
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- Macrocytic
- Target Cells - Fetal Hemoglobin - Altered Enzyme Activities - Altered membrane antigen expression |
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Neonotal Period
and Erythrocytes |
Birth - 1 month
- marked erythropoietic activity at birth - increased reticulocytes - predominance of fetal erythrocytes - increased erythrocyte MCV (MCV=109) - Hgb = 18 |
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Early Infancy
and Erythrocytes |
2 – 6 months
- Physiologic (adaptational) anemia - Hemoglobin nadir @ 8-10 weeks of age - Hematopoietic recovery with increased reticulocytes at end of "physiologic" anemia |
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Effects of Prematurity on Erythrocytes
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- Physiologic anemia develops EARLIER and has a LOWER NADIR
- Increased risk for Iron Deficiency Anemia |
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Are bigger babies at less of a risk to have iron deficiency anemia?
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Yes because they are born with more iron
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Late Infancy
and Erythrocytes |
6-24 months
- rapid somatic growth, increased iron requirements - nutritional iron deficiency anemia prevalent - "adult-type" erythrocytes predominate |
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Childhood and Blood Composition
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- "Adult-type" erythrocytes predominant
- WBC differential shows increasing neutrophils and decreasing lymphocyte |
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During infancy, what WBC is most represented in blood?
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Lymphocytes
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Adolescense and Blood
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- Rapid Somatic growth
- Increased nutritional iron requirement - gender differences appear in hemoglobin levels (androgenic effect) |
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List the Neonatal Anemias
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Hemorrhage:
- Feto-Maternal Bleeding - Feto-fetal bleeding Hemolysis - Inherited Red Cell Disorders - Alloimmune |
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How do you dx Feto-Maternal Bleeding?
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by finding fetal RBCs in mom's blood
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Alloimmune Hemolytic Anemia of the Newborn
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IgG can cross the placenta and hemolyze fetal erythrocytes if mother is immunized to a red cell antigen inherited from the father
- dx with coombs test |
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Hereditary Shperocytosis
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- Most common hemolytic aremia due to a membrane defect
- The defects are mutations in proteins that link vertically with the lipid bilayer (BAND 3, ANKYRIN, BAND 4.1 and SPECTRIN) |
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Clinical and Laboratory findings in Hereditary Spherocytosis
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- Splenomegaly
- Neonatal Jaundice - Cholelithiasis - Autosomal Dominant (75%) - Response to splenectomy - Increased MCHC .: very dense cells - - |
