W 2011 Pharm Gi Drugs For Pas

Front 1

Cimetidine
famotidine
ranitidine

Back 1

H2 receptor antagonists

Front 2

-inhibit meal-related and basal secretion of gastric acid

Reduces
~Pepsin
~Intrinsic Fctr
secretion

Back 2

H2-receptor antagonists.

Cimetidine
Famotidine
Ranitidine

Front 3

Can also use to tx allergies when the primary drugs aren't working

Back 3

H2-receptor antagonists. (representative drugs: cimetidine
famotidine
ranitidine)

Front 4

Most effective when taken 30 min prior to a provoking meal

Back 4

H2-receptor antagonists. (representative drugs: cimetidine
famotidine
ranitidine)

Front 5

PUD tx: how often to take H2 blockers?

Back 5

Once or twice daily
single dose at bedtime is good to keep acid secretion down all night
ppis preferred

Front 6

How long does it take h2 blockers to heal a peptic ulcer?

Back 6

6-8 weeks
better to use a PPI- only takes 4 weeks

Front 7

CP450 enzymes inhibitor

inhibits:
~Lovastatin
~Warfarin
~Other Rx-s in its class don't.

Back 7

Cimetidine

Inhibitor of: (enzyme)

Inhibits 2 Rx-s?

Hint 7

CP450 enzymes inhibitor


~Lovastatin
~Warfarin

Front 8

These drugs suppress IF
but not enough to cause B12 deficiency.

Back 8

H2-receptor antagonists. (representative drugs: cimetidine
famotidine
ranitidine)

Front 9

Low dose
OTC drugs to tx dyspepsia

Back 9

H2-receptor antagonists.

Front 10

Displays anti androgenic activity and can cause gynecomastia
uncommon in other drugs in its class

Back 10

Cimetidine- alts are famotidine
ranitidine

Front 11

These drugs can produce a dose dependent 95% inhibition of gastric acid secretion

Back 11

Ppis (omeprazole)

Front 12

Drug of choice for Zollinger Ellison syndrome

Back 12

Ppis (omeprazole)

Front 13

T or F- you can use the same dose PPI for ZE syndrome

Back 13

F
you usually need more

Front 14

Most effective drug for tx of GERD

Back 14

Ppis

Front 15

What does the nonprescription strength ppis tx?

Back 15

Dyspepsia and heartburn

Front 16

Used in preventing damage from long-term NSAID use

Back 16

Ppis (omeprazole)

Front 17

S/E:

Minor GI
CNS side effects
Rash
LFT elevations
can occur

Nm Rx Class?
Nm Rx?

Back 17

PPIs
Omeprazole


S?E?
4ct

Hint 17

Minor GI
CNS side effects
Rash
LFT elevations
can occur

Front 18

Neutralize stomach acid

Back 18

Antacids

(caco3)
AKA?

Hint 18

Calcium Carbonate

Front 19

Can cause constipation or rebound in acid secretion

Back 19

Antacids

Front 20

Available OTC in combination with an h2 antagonist

Back 20

Antacids

Front 21

Reason antacids no longer used for PUD

Back 21

Do not control nocturnal acid secretion
had to be taken in large doses


What type of Rx-s?

Hint 21

antacids

Front 22

Nm Class
Nm Rx
2ct

Adheres to Ulcer Craters
and
Inhibits Pepcid digestion of mucosal proteins

Back 22

Cytoprotective Rx

~Sucralfate
~Misoprostol

Front 23

Stimulates prostaglandin synthesis in mucosal cells

Back 23

Sucralfate

Stimulates ?

Hint 23

prostaglandin synthesis in mucosal cells

Front 24

Patients absorb a small amount of aluminum from the drug
so this drug should be used cautiously in renal patients

Back 24

Sucralfate

What is the concern
& for what impaired Pts?

Hint 24

Patients absorb a small amount of aluminum from Rx

So this drug should be used cautiously in
~Renal patients

Front 25

Used as a tx for
PUD

if H2 blockers
or
PPIs

cannot be used

Back 25

Sucralfate


Used as a tx for ?

Hint 25

Used as a tx for
PUD

if H2 blockers
or
PPIs

cannot be used

Front 26

Impairs absorption of fluoroquinolones

Back 26

Misoprostol


Impairs ?

Hint 26

Impairs absorption of fluoroquinolones

Front 27

~Inhibits gastric acid secretion

~Promotes the secretion of:
-Bicarb
-Mucus

Back 27

Misoprostol

~Inhibits?
~Promotes?

Hint 27

~Inhibits gastric acid secretion

~Promotes the secretion of bicarb and mucus

Front 28

For long term NSAID users who are at risk for getting PUD

Back 28

Misoprostol

Hint 28

For long term NSAID users
who are at risk for getting
~PUD

Front 29

Can induce labor

Back 29

Misoprostol


Can Induce ?

Hint 29

Can Induce labor

Front 30

-Increases esophageal sphincter pressure
-Blocks d2 receptors
(Dopa delays stomach emptying - this blocks Dopamine)
-Increases GI tone
-Increases mobility in Esophagus
-Increases Stomach Motility

Back 30

Prokinetics (metoclopramide)

How does it work?
5ct

Hint 30

-Increases esophageal sphincter pressure
-Blocks d2 receptors
(Dopamine delays stomach emptying - this blocks Dopamine)
-Increases GI tone
-Increases mobility in Esophagus
-Increases mobility in Stomach

Front 31

Used for
acute chronic and diabetic gastroparesis
as well as
GERD
intractable hiccup
facilitation of intubation of the small bowel
antiemetic

Back 31

Prokinetic (metoclopramide)


Used for ?
5ct

Hint 31

~Gastroparesis (acute chronic & diabetic )
~GERD
~Intractable hiccup
~Facilitation of intubation of the small bowel
~Antiemetic

Front 32

CONTRAINDICATED in Pts with

-GI Mechanical obstruction
-GI Hemorrhage
-Pheos
-Seizures

Back 32

(Metoclopramide)
(is also classified as a ?)


CONTRAINDICATED in Pts with

Hint 32

~Prokinetic

-GI Mechanical obstruction
-GI Hemorrhage
-Pheo-s
-Seizures

Front 33

Prokinetic

Back 33

Metoclopramide

Nm Receptor

Agonist or Antagonist

Hint 33

D2

Antagonist

Front 34

Indigestible hydrophilics that absorb and retain water resulting in distention in the intestines
which stimulates peristalsis

Back 34

Bulk-forming laxatives (psyllium)

Front 35

Preferred drugs for chronic constipation
also used in tx of diarrhea

Back 35

Bulk-forming laxatives (psyllium)

Front 36

Aka surfactant laxatives
these drugs facilitate the absorption of water into fatty intestinal material and soften the feces

Back 36

Stool softeners (docusate sodium)

Front 37

Stool softener

Back 37

Docusate sodium

Front 38

Indicated for hard and dry stool
painful passage: avoidance of straining necessary EX. Hemorrhoids
post-surgery

Back 38

Stool softeners (docusate sodium)

Front 39

Osmotic laxative

Back 39

Milk of magnesia

Front 40

Poorly absorbed inorganic salts retain water in lumen
stimulating peristalsis

Back 40

Osmotic laxatives (milk of magnesia)

Front 41

Evacuation of the bowel prior to surgery or diagnostic imaging
prevent constipation in pts taking opioids

Back 41

Osmotic laxatives (milk of magnesia)

Front 42

Can lead to Excessive loss of fluids/ electrolytes: NOT good for chronic constipation
renal impairment

Back 42

Osmotic laxatives (milk of magnesia)

Front 43

Senna

Back 43

Stimulant laxatives

Front 44

Bisacodyl

Back 44

Stimulant laxatives

Front 45

Act on intestinal mucosa to alter fluid secretion/ stimulate peristalsis

2ct

Back 45

Stimulant laxatives

-senna
-bisacodyl

MOA?

Hint 45

Act on intestinal mucosa to alter fluid secretion/ stimulate peristalsis

Front 46

Used for short term tx of constipation
presurgical bowel evacuation

(Not MOM)

-Nm Class
-Nm Rx-s 2ct

Back 46

Stimulant Laxatives

senna
bisacodyl

Used for short term tx of

Hint 46

-constipation
-presurgical bowel evacuation

Front 47

Serotonin 5-HT3 receptor antagonist

Back 47

Ondansetron

Front 48

During CA chemo

-Serotonin is released from ...
-Entero chromaffin cells...

-What receptors are stimulated?
-Where are they located?

Back 48

~ 5 HT3 receptors
in the
~ CTZ and the
~ Solitary Tract Nucleus

Front 49

Chemo stimulates the CTZ. What drug competes and inactivates the receptors involved?

Back 49

5-HT3 receptor antagonists

Nm Rx?

Hint 49

~Ondansetron

Front 50

What drug has been confirmed to control post-op nausea and vomiting?

Back 50

Ondansetron

Front 51

Adverse effects: anaphylactoid reactions

Back 51

Ondansetron


A/E:

Hint 51

anaphylactoid reactions
for what anti-Emetic?

Front 52

(prochlorperazine)

Nm Class?

Back 52

Phenothiazines (Class)


(Sound alike Rx)
-Promethazine
Nm Class?

Hint 52

-Antihistamines

Front 53

Inhibit stimulation of CNS vomiting center
d2 receptor blockers
2ct

Back 53

-Prochlorperazine
-Metoclopramide


Inhibit stimulation of ?

Hint 53

CNS vomiting center
-D2 receptor blockers


CLARIFICATION POINT:

RX ............. ......... Class
~Prochlorperazine - (Phenothiazines )

~Promethazine - (Antihistamines )

Front 54

Receptors found in the CTZ and solitary tract nucleus

3ct

Back 54

~ 5ht3
~ D2
~ M1

Where are they found?

Hint 54

Receptors found in the CTZ and solitary tract nucleus

Front 55

Found in CTZ...
Solitary tract nucleus

& between the

Vestibular apparatus and vomiting center

Back 55

M1

Found Where?

Hint 55

Found in CTZ...
Solitary tract nucleus

& between the

Vestibular apparatus and vomiting center

Front 56

Non-Chemotherapy N/V

What Rx
2ct

Back 56

~Prochlorperazine (Nm Class?)
~Metoclopramide (Nm Class)

What do they not cover?

Hint 56

~Phenothiazines

~D2 Antagonist


~Not for Chemotherapy N/V

Front 57

Non Rx derivative
Inhibits CNS vomiting center

Back 57

Marijuana derivatives

Nm Rx-Nm

• Also used for?
Inhibits what part of the Brain?

Hint 57

-Dronabinol

Inhibits CNS vomiting center (Medulla)

• Also an appetite stimulant for anorexic pts with AIDS

Front 58

Chemotherapy-induced emesis

not as good as serotonin 5ht3 antagonists
but
about as effective as:

-Phenothiazines
(Prochlorperazine)

Back 58

Marijuana derivatives

Rx Nm?

Hint 58

-Dronabinol

Front 59

MOA is
~H1 receptor blocker

but also has significant

~antimuscarinic activity

Back 59

~Promethazine
What Over All Class?

MOA ?
Also has what anti ______ activity

Hint 59

Antihistamines

~H1 receptor blocker

~Anti Muscarinic

Front 60

Used to tx N/V induced by

~Meds
~Anesthetics
and
~a wide variety of stimuli.

Rx is Usually administered by
~Rectal
~Injection.

Back 60

Promethazine
(Nm Class?)

-Used to tx N/V induced by

Rx is Usually administered by ?
2ct

Hint 60

-Antihistamines

Used to tx N/V induced by
~Meds
~Anesthetics
~a wide variety of stimuli.

Administration Rts:
~Rectal
~Injection

Front 61

Used to tx motion sickness
is an m1 receptor agonist

Back 61

Scopolamine

What receptor?

Hint 61

an m1 receptor agonist