W 2011 Pharm Analgesics For Pas

Front 1

Amplifies pain impulses
promote inflammation and fever

Back 1

Prostaglandins

Front 2

Catalyzes the formation of prostaglandins

Back 2

Cyclooxygenase

Front 3

Decreases prostaglandin production through non selective cyclooxygenase inhibition

Back 3

Nsaids

Front 4

GI tract
platelet aggregation
hemostasis
cox 1 or 2?

Back 4

Cox 1

Nm S/E
3ct

Hint 4

GI tract
platelet aggregation
hemostasis

Front 5

Up regulated during inflammatory process

Back 5

Cox 2

Front 6

Analgesic
anti-inflammatory
and antipyretics

2ct

Back 6

Nsaids

including cox 2 inhibitors

Front 7

Other positive effects of

NSAIDS

Back 7

~Delays or slows alzheimer’s development

~Decreases risk Colon CA

What Rx

Hint 7

NSAIDS

Front 8

• GI bleed • peptic ulcers • renal and hepatic dysfunction

Back 8

Nsaids

Front 9

Indications of APAP

Back 9

Mild pain and fever

Front 10

Has only a weak antiinflammatory effect because it is inactivated by peroxides of inflamed tissues

Back 10

APAP

Front 11

Has little effect on cox 1 or 2
only use for mild pain and fever

Back 11

APAP

Front 12

Sufficient to cause life threatening hepatotoxicity

Back 12

20 to 30 tablets of acetaminophen

Front 13

Nonspecific inhibition of COX
used for thromboembolic disorders
high doses cause tinnitus or hyperventilation or bleeding
hypersensitivity in some

Back 13

ASA

Front 14

Inhibit cox; used for pain and inflammation caused by most anything;

Name Specific Rx
2ct


A/E

-GI upset
- renal toxicity
-hepatic toxicity

Back 14

Ibu

naproxen

Front 15

One of the most potent inhibitors of COX;

used for moderate to severe acute inflammation;

causes closure of PDA in infants

Back 15

Indomethacin

ketorolac

Use for Peds?

Hint 15

causes closure of PDA in infants

Front 16

Associated with hematologic toxicity; limit to short term use

Back 16

Indomethacin

Associated with

Hint 16

Associated with hematologic toxicity;

limit to short term use

Front 17

Available parenterally; used for

moderate Px
~dental surgery
~migraines
~allergic conjunctivitis
~postop ocular inflammation
~less GI effects

More Hematologic

Back 17

Ketorolac

Rt
Nm uses
4ct

SE 1ct

Hint 17

Available parenterally; used for

moderate Px
~dental surgery
~migraines
~allergic conjunctivitis
~postop ocular inflammation
~less GI effects

More Hematologic

Front 18

Potent analgesic
antipyretic
antiinflammatory;

does not inhibit platelet aggregation
low incidence of GI effects

Back 18

Celecoxib

Info points
2ct

Hint 18

does not inhibit platelet aggregation

low incidence of GI effects



Potent analgesic
antipyretic
antiinflammatory;

Front 19

Act primarily in peripheral tissues to inhibit the formation of algogenic or pain producing substances

Back 19

Nonopioid analgesics

Front 20

Class of Rx primarily in the
spinal cord and brain
to inhibit the
neurotransmission of pain

Back 20

Opioid analgesics

Front 21

Results for down regulation of opioid receptors

Back 21

Tolerance

Front 22

These sx are not effected by tolerance

Back 22

Constipation and miosis

Front 23

Rebound hyperexcitability is associated with this phenomenon

Back 23

Physical dependence

Front 24

The basis for outpatient tx with methadone or bupreorphine

Back 24

Cross tolerance

Front 25

Morphine
Methadone
Meperidine
Fentanyl
Oxycodone

Back 25

Strong opiod agonists

Mepiridine (Trade Nm?)

Hint 25

(Demerol) Generic Nm?

Front 26

Codeine
hydrocodone

Back 26

Moderate opioid agonists

Front 27

Pentazocine
butorphanol

Back 27

Mixed opioid agonist-antagonists

Front 28

Naloxone

Naltrexone


Agonist or Antagonists or Both
for what kind of receptor

Back 28

Opioid antagonists


Nm Rx
2ct

Hint 28

Naloxone

Naltrexone

Front 29

Strong opioid agonist
not parenteral

Back 29

Oxycodone

Trade Nm?

Hint 29

(Oxycontin)

Front 30

Strong opioid
can be used transdermal and transmucosal

Back 30

Fentanyl

Front 31

Can codeine or hydrocodone be given parenterally?

Back 31

No

Front 32

Can be given
Intranasally and parenterally

~for Pre and Post-op
~OB during Labor and delivery

moderate to severe pain

Back 32

Butorphanol

Trade Nm

Rt
Used for 2ct
Type of Px coverage

Hint 32

(Stadol)

Intranasally and parenterally

~for Pre and Post-op
~OB during Labor and delivery

moderate to severe pain

Front 33

Oral and Parenteral

~Pre and Post-op
~OB during Labor & Delivery

moderate to severe pain

Back 33

Pentazocine

route
uses 2ct
type of Px coverage

Hint 33

Oral and Parenteral

~Pre and Post-op
~OB during Labor & Delivery

moderate to severe pain

Front 34

Parenteral (opioid overdose and dependence)

Back 34

Naloxone

Front 35

Oral (opioid overdose and dependence)

Back 35

Naltrexone

Front 36

Used in many
chronic pain syndromes
causes little
~constipation
~respiratory depression
~drug dependence.

Adverse effects are

-memory loss.
-nausea
-vomiting

Back 36

Tramadol

-Used in?
-causes little: (3ct)
-Adverse effects are: (3ct)

Hint 36

Used in many
chronic pain syndromes

causes little
~constipation
~respiratory depression
~drug dependence.

A/E
-memory loss.
-nausea
-vomiting

Front 37

Helpful if pain is associated with peripheral nerve or nerve root sensitization. Found in some creams. It activates peripheral nociceptors on primary sensory neurons.

Back 37

Capsaicin

Front 38

Particularly effective in
pain syndromes with an intermittent lancinating quality
such as
trigeminal
postherpetic neuralgia
syndromes characterized by continuous burning neuropathic pain.

Back 38

Antiepileptics

useed for 3ct

Hint 38

trigeminal
postherpetic neuralgia
burning neuropathic pain.

Front 39

Most widely used
antidepressants for the Tx of chronic pain

may be more effective than SSRI.

beneficial in management of Px assoc w chronic fatigue syndrome.

Back 39

Tricyclic antidepressant drugs

Nm the info 3ct

Hint 39

Most widely used
antidepressants for the Tx of chronic pain

may be more effective than SSRI.

beneficial in management of Px assoc w chronic fatigue syndrome.