E2 Voltage-Gated Ion Channels I And Ii Review

Front 1

Ion channels are embedded in lipid bilayers and segregate different pools of ions. These ions (when these ion channels open) are able to move ________ their concentration gradients.

Back 1

Down

Front 2

What type of current does sodium generate?

Back 2

Inward Current

Front 3

What type of current does calcium generate?

Back 3

Inward Current

Front 4

What type of current does chloride generate?

Back 4

Inward Current

Front 5

What type of current does potassium generate?

Back 5

Outward Current

Front 6

Which ion has a higher concentration inside of the membrane as opposed to the outside of the membrane?

Back 6

Potassium

Front 7

Non-gated channels which are not regulated by voltage or other ligands are known as ________.

Back 7

Ionophores

Front 8

Gramicidin allows the passage of _____ and ____ ions.

Back 8

Na+
K+

Front 9

Nystatin allows the passage of ______ and ______ ions.

Back 9

Na+
K+

Front 10

Amphotericin allows the passage of _____ and _____ ions.

Back 10

Na+
K+

Front 11

Inward currents of Na+ would cause _____________ of the membrane potential.

Back 11

Depolarization

Front 12

Outward currents of K+ would cause _____________ of the membrane potential.

Back 12

Hyperpolarization

Front 13

The substrate of the Na+/K+ ATPase (pump) is ______.

Back 13

ATP

Front 14

The cofactors of the Na+/K+ ATPase are ______ and _____.

Back 14

Na+
K+

Front 15

The products of the Na+/K+ ATPase are ______ and _____.

Back 15

ADP
Pi

Front 16

Every time we run this pump and use up a molecule of ATP we move _____ sodium _____ and move _____ potassium _______ of the membrane.

Back 16

Three
Out
Two
Inside

Front 17

Digitalis
(Na+/K+ ATPase or Ca2+ ATPase?)

Back 17

Na+/K+ ATPase

Front 18

Ouabain
(Na+/K+ ATPase or Ca2+ ATPase?)

Back 18

Na+/K+ ATPase

Front 19

Thapsigargin

Back 19

Ca2+ ATPase

Front 20

Na+ Channels
(Depolarization/Hyperpolarization)

Back 20

Depolarization

Front 21

K+ Channels
(Depolarization/Hyperpolarization)

Back 21

Hyperpolarization

Front 22

Cl- Channels
(Depolarization/Hyperpolarization)

Back 22

Hyperpolarization

Front 23

Ca2+ Channels
(Depolarization/Hyperpolarization)

Back 23

Depolarization

Front 24

Aconitine
(Blocks Na+ channels/Stimulates Na+)
(Local Anesthetic/Cardiostimulant)

Back 24

Stimulates Na+ Channels
Cardiostimulant

Front 25

Saxitoxin
(Blocks Na+ channels/Stimulates Na+)

Back 25

Blocks Na+ Channels

Front 26

Tetrodotoxin
(Blocks Na+ channels/Stimulates Na+)

Back 26

Blocks Na+ Channels

Front 27

Cocaine
(Blocks Na+ channels/Stimulates Na+)
(Local Anesthetic/Cardiostimulant)

Back 27

Blocks Na+ Channels
Local Anesthetic

Front 28

Lidocaine
(Blocks Na+ channels/Stimulates Na+)
(Local Anesthetic/Cardiostimulant)

Back 28

Blocks Na+ Channels
Local Anesthetic

Front 29

Ropivacaine
(Blocks Na+ channels/Stimulates Na+)
(Local Anesthetic/Cardiostimulant)

Back 29

Blocks Na+ Channels
Local Anesthetic

Front 30

QX-314
(Blocks Na+ channels/Stimulates Na+)

Back 30

Blocks Na+ Channels

Front 31

Veratridine
(Blocks Na+ channels/Stimulates Na+)
(Local Anesthetic/Cardiostimulant)

Back 31

Stimulates Na+ Channels
Cardiostimulant

Front 32

IP3
(IP3 Receptor/Ryanodine Receptor)
(Agonist/Antagonist)

Back 32

IP3 Receptor
Agonist

Front 33

Ryanodine
(IP3 Receptor/Ryanodine Receptor)
(Agonist/Antagonist)

Back 33

Ryanodine Receptor
Agonist

Front 34

Free Ca2+
(IP3 Receptor/Ryanodine Receptor)
(Agonist/Antagonist)

Back 34

Ryanodine Receptor
Agonist

Front 35

Dantrolene
(IP3 Receptor/Ryanodine Receptor)
(Agonist/Antagonist)

Back 35

Ryanodine Receptor
Antagonist

Front 36

Heparin
(IP3 Receptor/Ryanodine Receptor)
(Agonist/Antagonist)

Back 36

IP3 Receptor
Antagonist

Front 37

T-type calcium channels are
(HVA/LVA)

Back 37

LVA

Front 38

L-type calcium channels are
(HVA/LVA)

Back 38

HVA

Front 39

N-type calcium channels are
(HVA/LVA)

Back 39

HVA

Front 40

P/Q-type calcium channels are
(HVA/LVA)

Back 40

HVA

Front 41

R-type calcium channels are
(HVA/LVA)

Back 41

HVA

Front 42

T-type calcium channels are
(FI/NI/SI)

Back 42

FI

Front 43

L-type calcium channels are
(FI/NI/SI)

Back 43

NI

Front 44

N-type calcium channels are
(FI/NI/SI)

Back 44

SI

Front 45

P/Q type calcium channels are
(FI/NI/SI)

Back 45

SI

Front 46

R-type calcium channels are
(FI/NI/SI)

Back 46

SI

Front 47

Verapamil

Back 47

L-type channels

Front 48

Nimodipidine

Back 48

L-type channels

Front 49

Omega-CTX-CVIA

Back 49

N-type channels

Front 50

Flunarizine

Back 50

T-type channels

Front 51

Omega-AGA-Ia

Back 51

P/Q type channels

Front 52

Inorganic Ions

Back 52

Blocks all channel types

Front 53

BAY-K-8644

Back 53

L-type channels

Front 54

Nifedipine

Back 54

L-type channels

Front 55

Diltiazem

Back 55

L-type channels

Front 56

Maitotoxin

Back 56

Stimulates all channels

Front 57

List a benzimidazole

Back 57

Flunarizine

Front 58

List a dihydropyrimidine

Back 58

Nifedipine or Nimodipine

Front 59

List an arylalkylamine

Back 59

Verapamil

Front 60

List a benzodiazepine

Back 60

Diltiazem

Front 61

There is not a known toxin or drug that can selectively block the ________ -type calcium channels.

Back 61

R