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89 Cards in this Set

  • Front
  • Back

Vitamin C

Antiscorbutic factor


Cevitamic acid


Hexuronic acid

Vitamin C

Most unstable vitamin

Adrenal gland and retina of the eyes

Vitamin C has high concentrations in the ______ and ______.

Watery stools or diarrhea

Unabsorbed vitamin C can lead to ____ or ____

Blood

Vitamin C is free flowing and transported through the ____

Vitamin C

Prevents oxidation of Vitamin A, Folic Acid, PUFA and THF

Vitamin C

Increases Iron and Calcium absorption

Vitamin C

Increases utilization of Iron, Calcium and Folic Acid

Vitamin C

Collagen formation


Carnitine synthesis


Hormone and neurotransmitter synthesis


Immunity


Amino acid metabolism


Antioxidant

Scurvy

Deficiency of vitamin C causes ___

35mg

Smoking increases Vitamin C requirements by __mg

Male: 70mg


Female: 60mg

Vitamin C RENI for adult male & female (mg)

Vitamin B1

Anti-neuritic factor


Anti-beriberi factor

Thiamin

Has both sulfur and nitrogen

TPP (thiamin pyrophosphate)

___ in food must be dephosphorylated to thiamin

Muscles

1/2 of thiamin in the body is stored in the __

Vitamin B1

Energy transformation thru oxidative decarboxylation of pyruvate & alpha ketoglutarate


NADH & pentose synthesis thru TPP in hexose monophosphate shunt





Vitamin B1

Membrane & nerve conductionTransketolationConversion of tryptophan to niacinRegulation of appetite and muscle tone

Beriberi (wet, dry, infantile)

Deficiency in thiamin and types

Wernicke korsakoff syndrome

Beriberi deficiency usually among alcohol abusers

Thiamin

Alcoholism


Pregnancy


Sulfonamide drugs


Sugars, starch, refined grains



These increase requirement for __

Fat

Thiamin requirement decreases as __ intake increases

Male: 1.2 mg


Female: 1.1 mg

Adult male & female RENI for Thiamin (mg)

Niacin

Nicotinamide acid


Nicotinamide


Niacinamide


Pellagra-preventive factor

Niacin

Converted to NAD, NADH, NADP, NADPH

60 mg dietary tryptophan = 1 mg niacin

__ mg dietary tryptophan = __ mg niacin

Niacin

Energy release of CPF


DNA formation thru protein, fat and pentose synthesis


Electron acceptor in catabolic reactions


Synthesis of FA, chol, steroid, glutamate, deoxyribonucleotide)

Pellagra

Niacin deficiency

Diarrhea, dermatitis, dementia, death

4Ds of pellagra

Niacin

Deficiency occurs to those with diets that rely mostly on untreated maize and barley and chronic alcoholics

Male: 16mg NE


Female: 14mg NE

Niacin RENI of Adult male & female (mg NE)

Vitamin B5

Pantothenic acid


Pantotheine


Pantothenol


Anti-chromotrichial factor

B5

Stable in moist heat but unstable in dry heat

Calcium pantothenate

Synthetic crystalline form of B5 usually in dietary supplements

B5

Vitamin which is a part of CoA

B5

Acetylation reactions (CoA cpt)


Energy production from CPF


Fat, chol, steroid synthesis

B5

Formation of heme grp in hemoglobin


Synthesis of acetyl choline for nerve impulse transmission


Branched chain AA metabolism


Maintenance and repair of tissues and cdlls of skin, hair, wounds, lesions

Pantheine

Cpt of b5 that normalizes blood lipid profiles

B5

Very rare to be deficient, can cause failure of all organ systems and burning feet syndrome

B5

Requirements are increased for alcoholics, DM and ulcerative colitis pxs

B6

Pyridoxine


Pyridoxal


Pyridoxamine

Pyridoxic acid

B6 is degraded into ___ acid to be excreted in the urine

PLP (Pyridoxal 5 phosphate)

Active form of B6 used to make non essential AA

B6

Isonicotinic acid hydrazide (INH) is an antagonist of __

B6

Coenzyme of 60+ enzymes


Transamination & deamination carboxylation


Carpal tunnel syndrome


PMS

B6

Synthesis of neurotransmitters, sphingolipids and delta-amino levulinic acid (heme precursor)


Conversion of tryptophan to niacin

B6

Ethanolamine & taurine production


MUFA & PUFA metabolism


Glucocorticoid action

Microcytic anemia

Deficiency in B6 leads to ______

Male: 1.3-1.7mg


Female: 1.3-1.6mg

Adult RENI of B6 for Male & Female (mg)

B6

Requirements increase if taking oral contraceptives, on dialysis, breastfed infants, elderly and alcoholics

INH and Penicillamine

B6 requirements increase if taking ___ (B6 antagonist and medicine for tuberculosis) and ___ (medicine for wilson's disease, cystinuria, rheumatoid arthritis)

B9 Folate

Citrovorum factor


Pteroyl glutamic acid


Lactobacillus casei factor


Vitamin M


Vitamin Bc


Factor U

PGA (pteroylmonoglutamic acid)

Simplest form of folate

THF

PGA, when combined with Vitamin C and Niacin, converts to __

B9 Folate

Coenzyme when in THF form


AA synthesis


Conversion of phenylalanine to tyrosine


Formation of heme grp in hemoglobin

B9 folate

Formation of purine & pyrimidine bases for DNA & RNA


Formation of choline from ethanolamine


Conversion of niacin to N-methyl nicotinamide for excretion

B9 folate

For breast cancer and pancreatic illness


Protect heart from homocysteine which causes blood clotting

Vitamin C

Oxidation of folate is prevented by __

Vitamin B12

Folate is aided by ___ to form methionine from homocysteine

Zinc

Increase in folate supplement decreases absorption of __

Folate

Deficiency usually occurs when diet lacks green leafy veg and legumes

Folate

Deficiency can cause neural tube defects for baby like spina bifida or anecephaly

B12

Decrease in ___ also decreases folate because __ can't donate methyl group to convert folate to its active form

Megaloblastic or macrocytic anemia

Decrease in folate can cause __ or __ anemia

400ug DFE

RENI of Adult male & female for folate

1ug DFE = 0.6ug synthetic folic acid = 0.5ug synthetic folic acid taken on empty stomach

1ug DFE = __ug synthetic folic acid = __ug synthetic folic acid taken on empty stomach

B12 cobalamin

Anti-pernicious anemia factor


Erythrocyte maturation factor


Animal pro factor

Corrinoids

___ or cobalamins has a cobalt atom in its nucleus center

Cyanocobalamin

Pharmaceutical form of B12

Cobalamin

Active form of b12

Trypsin

B12 is digested by enzyme __

B12

It combines with intrinsic factor (IF) in the stomach

B12

Absorption rate decreases if intake increases, aging d/t lack of gastric acid, with B6 deficiency d/t lack of released IF, Iron deficiency, hyperthyroidism, gastritis, taking anticonvulsants & antibiotics

B12

DNA synthesis


Cell growth & division


Myelin synthesis

B12

Conversion of malonyl CoA to succinyl CoA


Homocysteine to methionine via methyl group donation


Conversion of folate to active form for DNA synthesis

Pernicious anemia

B12 deficiency leads to ____ d/t IF deficiency

B12

Deficiency can cause neurologic changes due to demyelination

B12

Deficiency commonly in elderly, alcoholics, gastrectomy patients and vegans because it's naturally found in animal and animal products

2.4ug for both

Adult RENI of male & female for B12 (ug)

Biotin

Anti-egg white injury factor


Bios I



Biotin

Vitamin HCoenzyme RVitamin B7

Biocytin

Biologically active derivative of biotin produced in stomach

Avidin

Protein in raw egg whites that inactivates biotin by binding with it, making it unable to be utilized

Upper small intestine

Biotin is absorbed in the upper __

Biotin

Coenzyme of carboxylates (pyruvate in gluconeogenesis, acetyl CoA in FA synthesis, and both propionyl CoA and Beta-methyl crotonyl CoA or MCC in AA metab)

Biotin

Deamination of aspartic acid, threonine and serine


Synthesis of pancreatic amylase & nicotinic acid

Biotin

Formation of antibodies


Fat & protein metabolism of hair roots, fingernails, skin

Biotin

Deficiency is rare and can be caused by genetic defect or consumption of 6 or more raw eggs daily

Biotin

Increase requirements if with achlorydia, alcoholism, increase in egg white consumption, sulfonamide therapy, pregnant, lactating, epileptic, elderly