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89 Cards in this Set
- Front
- Back
Vitamin C |
Antiscorbutic factor Cevitamic acid Hexuronic acid |
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Vitamin C |
Most unstable vitamin |
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Adrenal gland and retina of the eyes |
Vitamin C has high concentrations in the ______ and ______. |
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Watery stools or diarrhea |
Unabsorbed vitamin C can lead to ____ or ____ |
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Blood |
Vitamin C is free flowing and transported through the ____ |
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Vitamin C |
Prevents oxidation of Vitamin A, Folic Acid, PUFA and THF |
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Vitamin C |
Increases Iron and Calcium absorption |
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Vitamin C |
Increases utilization of Iron, Calcium and Folic Acid |
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Vitamin C |
Collagen formation Carnitine synthesis Hormone and neurotransmitter synthesis Immunity Amino acid metabolism Antioxidant |
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Scurvy |
Deficiency of vitamin C causes ___ |
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35mg |
Smoking increases Vitamin C requirements by __mg |
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Male: 70mg Female: 60mg |
Vitamin C RENI for adult male & female (mg) |
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Vitamin B1 |
Anti-neuritic factor Anti-beriberi factor |
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Thiamin |
Has both sulfur and nitrogen |
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TPP (thiamin pyrophosphate) |
___ in food must be dephosphorylated to thiamin |
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Muscles |
1/2 of thiamin in the body is stored in the __ |
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Vitamin B1 |
Energy transformation thru oxidative decarboxylation of pyruvate & alpha ketoglutarate NADH & pentose synthesis thru TPP in hexose monophosphate shunt |
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Vitamin B1 |
Membrane & nerve conductionTransketolationConversion of tryptophan to niacinRegulation of appetite and muscle tone |
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Beriberi (wet, dry, infantile) |
Deficiency in thiamin and types |
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Wernicke korsakoff syndrome |
Beriberi deficiency usually among alcohol abusers |
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Thiamin |
Alcoholism Pregnancy Sulfonamide drugs Sugars, starch, refined grains These increase requirement for __ |
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Fat |
Thiamin requirement decreases as __ intake increases |
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Male: 1.2 mg Female: 1.1 mg |
Adult male & female RENI for Thiamin (mg) |
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Niacin |
Nicotinamide acid Nicotinamide Niacinamide Pellagra-preventive factor |
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Niacin |
Converted to NAD, NADH, NADP, NADPH |
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60 mg dietary tryptophan = 1 mg niacin |
__ mg dietary tryptophan = __ mg niacin |
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Niacin |
Energy release of CPF DNA formation thru protein, fat and pentose synthesis Electron acceptor in catabolic reactions Synthesis of FA, chol, steroid, glutamate, deoxyribonucleotide) |
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Pellagra |
Niacin deficiency |
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Diarrhea, dermatitis, dementia, death |
4Ds of pellagra |
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Niacin |
Deficiency occurs to those with diets that rely mostly on untreated maize and barley and chronic alcoholics |
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Male: 16mg NE Female: 14mg NE |
Niacin RENI of Adult male & female (mg NE) |
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Vitamin B5 |
Pantothenic acid Pantotheine Pantothenol Anti-chromotrichial factor |
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B5 |
Stable in moist heat but unstable in dry heat |
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Calcium pantothenate |
Synthetic crystalline form of B5 usually in dietary supplements |
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B5 |
Vitamin which is a part of CoA |
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B5 |
Acetylation reactions (CoA cpt) Energy production from CPF Fat, chol, steroid synthesis |
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B5 |
Formation of heme grp in hemoglobin Synthesis of acetyl choline for nerve impulse transmission Branched chain AA metabolism Maintenance and repair of tissues and cdlls of skin, hair, wounds, lesions |
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Pantheine |
Cpt of b5 that normalizes blood lipid profiles |
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B5 |
Very rare to be deficient, can cause failure of all organ systems and burning feet syndrome |
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B5 |
Requirements are increased for alcoholics, DM and ulcerative colitis pxs |
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B6 |
Pyridoxine Pyridoxal Pyridoxamine |
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Pyridoxic acid |
B6 is degraded into ___ acid to be excreted in the urine |
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PLP (Pyridoxal 5 phosphate) |
Active form of B6 used to make non essential AA |
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B6 |
Isonicotinic acid hydrazide (INH) is an antagonist of __ |
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B6 |
Coenzyme of 60+ enzymes Transamination & deamination carboxylation Carpal tunnel syndrome PMS |
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B6 |
Synthesis of neurotransmitters, sphingolipids and delta-amino levulinic acid (heme precursor) Conversion of tryptophan to niacin |
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B6 |
Ethanolamine & taurine production MUFA & PUFA metabolism Glucocorticoid action |
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Microcytic anemia |
Deficiency in B6 leads to ______ |
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Male: 1.3-1.7mg Female: 1.3-1.6mg |
Adult RENI of B6 for Male & Female (mg) |
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B6 |
Requirements increase if taking oral contraceptives, on dialysis, breastfed infants, elderly and alcoholics |
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INH and Penicillamine |
B6 requirements increase if taking ___ (B6 antagonist and medicine for tuberculosis) and ___ (medicine for wilson's disease, cystinuria, rheumatoid arthritis) |
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B9 Folate |
Citrovorum factor Pteroyl glutamic acid Lactobacillus casei factor Vitamin M Vitamin Bc Factor U |
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PGA (pteroylmonoglutamic acid) |
Simplest form of folate |
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THF |
PGA, when combined with Vitamin C and Niacin, converts to __ |
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B9 Folate |
Coenzyme when in THF form AA synthesis Conversion of phenylalanine to tyrosine Formation of heme grp in hemoglobin |
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B9 folate |
Formation of purine & pyrimidine bases for DNA & RNA Formation of choline from ethanolamine Conversion of niacin to N-methyl nicotinamide for excretion |
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B9 folate |
For breast cancer and pancreatic illness Protect heart from homocysteine which causes blood clotting |
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Vitamin C |
Oxidation of folate is prevented by __ |
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Vitamin B12 |
Folate is aided by ___ to form methionine from homocysteine |
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Zinc |
Increase in folate supplement decreases absorption of __ |
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Folate |
Deficiency usually occurs when diet lacks green leafy veg and legumes |
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Folate |
Deficiency can cause neural tube defects for baby like spina bifida or anecephaly |
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B12 |
Decrease in ___ also decreases folate because __ can't donate methyl group to convert folate to its active form |
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Megaloblastic or macrocytic anemia |
Decrease in folate can cause __ or __ anemia |
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400ug DFE |
RENI of Adult male & female for folate |
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1ug DFE = 0.6ug synthetic folic acid = 0.5ug synthetic folic acid taken on empty stomach |
1ug DFE = __ug synthetic folic acid = __ug synthetic folic acid taken on empty stomach |
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B12 cobalamin |
Anti-pernicious anemia factor Erythrocyte maturation factor Animal pro factor |
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Corrinoids |
___ or cobalamins has a cobalt atom in its nucleus center |
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Cyanocobalamin |
Pharmaceutical form of B12 |
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Cobalamin |
Active form of b12 |
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Trypsin |
B12 is digested by enzyme __ |
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B12 |
It combines with intrinsic factor (IF) in the stomach |
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B12 |
Absorption rate decreases if intake increases, aging d/t lack of gastric acid, with B6 deficiency d/t lack of released IF, Iron deficiency, hyperthyroidism, gastritis, taking anticonvulsants & antibiotics |
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B12 |
DNA synthesis Cell growth & division Myelin synthesis |
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B12 |
Conversion of malonyl CoA to succinyl CoA Homocysteine to methionine via methyl group donation Conversion of folate to active form for DNA synthesis |
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Pernicious anemia |
B12 deficiency leads to ____ d/t IF deficiency |
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B12 |
Deficiency can cause neurologic changes due to demyelination |
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B12 |
Deficiency commonly in elderly, alcoholics, gastrectomy patients and vegans because it's naturally found in animal and animal products |
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2.4ug for both |
Adult RENI of male & female for B12 (ug) |
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Biotin |
Anti-egg white injury factor Bios I |
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Biotin |
Vitamin HCoenzyme RVitamin B7 |
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Biocytin |
Biologically active derivative of biotin produced in stomach |
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Avidin |
Protein in raw egg whites that inactivates biotin by binding with it, making it unable to be utilized |
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Upper small intestine |
Biotin is absorbed in the upper __ |
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Biotin |
Coenzyme of carboxylates (pyruvate in gluconeogenesis, acetyl CoA in FA synthesis, and both propionyl CoA and Beta-methyl crotonyl CoA or MCC in AA metab) |
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Biotin |
Deamination of aspartic acid, threonine and serine Synthesis of pancreatic amylase & nicotinic acid |
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Biotin |
Formation of antibodies Fat & protein metabolism of hair roots, fingernails, skin |
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Biotin |
Deficiency is rare and can be caused by genetic defect or consumption of 6 or more raw eggs daily |
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Biotin |
Increase requirements if with achlorydia, alcoholism, increase in egg white consumption, sulfonamide therapy, pregnant, lactating, epileptic, elderly |