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7 Cards in this Set

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  • Back
How is Mo transported in plasma?
Bound to macroglobulin
Excretion of Mo?
Urine: by excretion
Name two Mo-dependent enzymes
& what are their rxns?
Xanthine Oxidase:
hypoxanthine-->xanthine-->uric acid
** for purine synthesis

Sulfite Oxidase:
Sulfite is toxic; sulfate needed in some rxns.
What genetic impairment can lead to a deficiency in Mo?
The inability to synthesize the cofactor which Mo is in. This is the form that is used in enzymes.
So what happens?
Well, there is no measured activity of the ezymes; as a result, high levels of hypoxnathine, xanthine, and sulfite and in urine.

Condition is deadly. Shrinkage of brain, dislocation of eye lens, neurological issues.
What is the Mo-cofactor?
It's the form of Mo which is used in enzymes. If you cannot produce the cofactor, you cannot use any of the enzymes. Not good!!