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5 Cards in this Set
- Front
- Back
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What enzyme is required for pyruvate carboxylase (gluconeogenesis), Acetyl CoA carboxylase (FA synthesis) and Propionyl CoA synthesis (odd carbon FAs, Val, Met, Ile, Thr)?
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Biotin
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What are the SEs of biotin deficiency?
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MCC: excessive raw egg consumption (avidin binds biotin)
SEs: alopecia, muscle pain, bowel inflammation |
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What enzymes require thiamine (B1)?
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Pyruvate dehydrogenase (PDH)
alpha-ketoglutarate dehydrogenase (TCA) Transketolase (HMP Shunt) |
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What is the MCC and SEs of thiamin deficiency?
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MCC: alcoholism (interferes w/ absorption)
Wernicke's: ataxia, nystagmus, opthalmoplegia Korsakoff: confabulation, psychosis Wet Beri-Beri: high CO failure, Dry Beri-Beri (no fluid retention) |
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Niacin (B3)
NAD(H) NADP(H) |
Enzyme: Dehydrogenases
Pathway: Many DZ: Pellara (diarrhea, demetia, dermatitis, death w/o tx) pellagra also related to tryptophan deficiency (related to corn = staple) |
