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47 Cards in this Set

  • Front
  • Back
What is the active form of:
Thiamine
TPP
What is the active form of: pyroxidine
pyridoxal phosphate
What is the active form of: niacine
niacine and nicotinamide
What is the active form of: folate
tetrahydrofolate (THF)
What is the active form of: cobalamine
methylcobalamine
5-deoxyadenosylcobalamine
What is the active form of: riboflavin
Flavin Mononucleiotide (FNM),
Flavin adenine dinucleotide (FAD)
What is the active form of: Retinoid
retinol. retinal,retinoic acid
B1=
thiamine
B6=
pyroxidine
b3=
niacin
b12=
cobalamine
b2=
riboflavin
b5=
pantothenic acid
vitamin a=
retinoida
Thiamine function
transketolase activity and oxidative decarboxylation
involved in ATP production
Sx of thiamine deficiency
beriberi
werneki korsakoff
Pyroxidine function
(b6) transfer of amino grups
sx of pyroxidine deficincy
sideroblastic anemia
the body has iron available but cannot incorporate it into hemoglobin, which red blood cells need to transport oxygen efficiently.
niacin function
coenzymes NAD and NADP, mainly to accept or donate electrons for redox reactions
niacin deficiency disorders
pellagra
4d's
dermititis, diahrreah, death, dimentia
Folate function
one carbon metabolism
what vitamin can be synthesized from tryptophan?
niacin
Disorders resulting from folate def?
macrocytic, megaloblastoc anemia
Vitamin A function
Cell signaling, vision, reproduction
vitamin k function
coagulation
vitamin C active form?
ascorbate
Vitamin C function
reducing agent: minimize radical damage, recycles vitamin e
required as a cofactor in the hydroxylation of lysine and proline residues in collagen
#
oxidized to dehydroascorbic acid
Vitamin C def sx:
bleeding gums, loose teeth, fragile blood vessles., corkscrew hairs, problems with connective tissue such that collagen fibers can't be cross linked
toxicity of vitamin c
kidney stones and diahhrea
vitamin e active form
a-tocopherol
function of vitamin e
antioxidant
decreases lipid peroxidation
Vitamin E toxicity:
least common of fat soluble vitamins but can interact with vitamin k and may affect platelet activity leading to increased risk of bleeding
selenium function
(selenocystine) is required for synthesis and activity of glutathione peroxidase
True or false, vitamin A has antioxidant properties...
FALSE
G0-G1 signaling
by a mitogen to signal cell to make cyclin d wich will then activateCDK4/6 COmplex
G1 Restriction point enzymes
1) D4/D6 hypophosphorlates RB
2)E2 hyperphosphorilates RB causing it to releas E2F
Where can p16 act?
Where can p21 act?
p16 can only act at cyclinD/cdk4/6
P21 can act on any other cycling complex, like cyclinE/CDK2 later in G1
How does the cell get through the G2-M Checkpoint?
cdc25 is released by the cell when DNA dupication is complete. cdc25 activates the MPF (B/CDC2) complex. Active MPF signals events associated with mitosis.
What is the M/Spindle Assembly checkpoint?
APC gives the "all clear" when the chromosomes are properly aligned. APC then turns off MPF (b/cdc2) by degrading cyclin b and it also uiquinates securin which frees seperase to unglue the chromosomes so that they can be split
Daily Caloric Needs Formula
RMR + Physical Activity + TEF
RMR (Men & Women)
(wt in kg) x (1kcal/kg/hr, men, 0.9 women) x (24 hours)
IBW (men and women)
M= 106 + (6# for every inch over 5ft) +/- 10%

W= 100 +/- (5# above or below 5ft) +/- 10%
BMI=
wt in kg/ht in m2
Ergocalciferol
D2 (1/3 as active)
Vitamn D3 active name and formula
calcitriol 1,25(OH)2D3
Vitamn D3 made in liver (inactive) name and formula
calcidiol 1,25(OH)D3
Enzyme in kidney that makes D3 active?
1,25(OH)D3-1a-hydroxylase