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47 Cards in this Set
- Front
- Back
What is the active form of:
Thiamine |
TPP
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What is the active form of: pyroxidine
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pyridoxal phosphate
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What is the active form of: niacine
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niacine and nicotinamide
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What is the active form of: folate
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tetrahydrofolate (THF)
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What is the active form of: cobalamine
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methylcobalamine
5-deoxyadenosylcobalamine |
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What is the active form of: riboflavin
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Flavin Mononucleiotide (FNM),
Flavin adenine dinucleotide (FAD) |
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What is the active form of: Retinoid
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retinol. retinal,retinoic acid
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B1=
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thiamine
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B6=
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pyroxidine
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b3=
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niacin
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b12=
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cobalamine
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b2=
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riboflavin
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b5=
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pantothenic acid
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vitamin a=
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retinoida
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Thiamine function
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transketolase activity and oxidative decarboxylation
involved in ATP production |
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Sx of thiamine deficiency
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beriberi
werneki korsakoff |
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Pyroxidine function
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(b6) transfer of amino grups
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sx of pyroxidine deficincy
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sideroblastic anemia
the body has iron available but cannot incorporate it into hemoglobin, which red blood cells need to transport oxygen efficiently. |
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niacin function
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coenzymes NAD and NADP, mainly to accept or donate electrons for redox reactions
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niacin deficiency disorders
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pellagra
4d's dermititis, diahrreah, death, dimentia |
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Folate function
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one carbon metabolism
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what vitamin can be synthesized from tryptophan?
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niacin
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Disorders resulting from folate def?
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macrocytic, megaloblastoc anemia
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Vitamin A function
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Cell signaling, vision, reproduction
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vitamin k function
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coagulation
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vitamin C active form?
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ascorbate
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Vitamin C function
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reducing agent: minimize radical damage, recycles vitamin e
required as a cofactor in the hydroxylation of lysine and proline residues in collagen # oxidized to dehydroascorbic acid |
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Vitamin C def sx:
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bleeding gums, loose teeth, fragile blood vessles., corkscrew hairs, problems with connective tissue such that collagen fibers can't be cross linked
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toxicity of vitamin c
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kidney stones and diahhrea
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vitamin e active form
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a-tocopherol
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function of vitamin e
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antioxidant
decreases lipid peroxidation |
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Vitamin E toxicity:
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least common of fat soluble vitamins but can interact with vitamin k and may affect platelet activity leading to increased risk of bleeding
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selenium function
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(selenocystine) is required for synthesis and activity of glutathione peroxidase
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True or false, vitamin A has antioxidant properties...
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FALSE
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G0-G1 signaling
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by a mitogen to signal cell to make cyclin d wich will then activateCDK4/6 COmplex
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G1 Restriction point enzymes
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1) D4/D6 hypophosphorlates RB
2)E2 hyperphosphorilates RB causing it to releas E2F |
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Where can p16 act?
Where can p21 act? |
p16 can only act at cyclinD/cdk4/6
P21 can act on any other cycling complex, like cyclinE/CDK2 later in G1 |
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How does the cell get through the G2-M Checkpoint?
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cdc25 is released by the cell when DNA dupication is complete. cdc25 activates the MPF (B/CDC2) complex. Active MPF signals events associated with mitosis.
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What is the M/Spindle Assembly checkpoint?
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APC gives the "all clear" when the chromosomes are properly aligned. APC then turns off MPF (b/cdc2) by degrading cyclin b and it also uiquinates securin which frees seperase to unglue the chromosomes so that they can be split
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Daily Caloric Needs Formula
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RMR + Physical Activity + TEF
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RMR (Men & Women)
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(wt in kg) x (1kcal/kg/hr, men, 0.9 women) x (24 hours)
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IBW (men and women)
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M= 106 + (6# for every inch over 5ft) +/- 10%
W= 100 +/- (5# above or below 5ft) +/- 10% |
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BMI=
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wt in kg/ht in m2
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Ergocalciferol
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D2 (1/3 as active)
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Vitamn D3 active name and formula
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calcitriol 1,25(OH)2D3
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Vitamn D3 made in liver (inactive) name and formula
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calcidiol 1,25(OH)D3
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Enzyme in kidney that makes D3 active?
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1,25(OH)D3-1a-hydroxylase
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