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31 Cards in this Set
- Front
- Back
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Vitamin D is AKA |
Calciferol |
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Disease in kids characterized by altered bone development, could be prevented by Vit D supplementation or sunlight exposure |
Rickets |
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Vitamin D is a _____ steroid because one ring is broken |
Seco |
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D2 and D3 differ in the structure of the ____ |
Side chain |
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Found in the skin and produced by the sebaceous gland, precursor to D3 |
7-dehydrocholesterol |
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Allows for the absorption of wavelengths in UV range (285-325nm) forming previtamin D |
Double bonds in Ring B |
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D3 then Diffuses from the skin into blood and binds the |
Vitamin D Binding Protein |
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In SI is digestion needed for absorption? |
No |
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Vit D is absorped in _____ by ____ |
micelles by passive diffusion |
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In the blood Chylomicrons transport ____% of vitamin D |
40 |
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____ deliver Vit D to the liver |
Chylo Remnants |
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Vitamin D is hydroxylated by NADPH dependent enzyme called |
25-Hydroxylase |
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25-hydroxylaseis mostly found in the ___ in the _____ and produces 25-OH vitamin D |
liver, mito |
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Main form of Vitamin D in the body |
25-OH Vit D |
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Major storage site of 25-OH D |
Blood |
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25-OH D binding to DBP is taken up by binding to receptors: |
Cubilin and Megalin |
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Uptake of 25-OH D in kidney and other tissues is upregulated by an increase in concentration of this hormone |
Parathyroid |
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PTH is secreted when calcium and Phos levels are high or low? |
Low |
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PTH increases the synthesis of ____ which produces ____ |
1 Hydroxylase, 1,25-OH D |
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Stimulates the production of PTH to increase Ca |
Hypocalcemia |
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Increased 1,25-OH D ____ synthesis of 1 Hydroxylase and stimulates expression of 24 Hydroxylase inactivating Vit D |
Inhibits |
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Decreased 1,25-OH ____ the synthesis of 1 hydroxylase |
Stimulates |
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Binding to membrane associated rapid steriod (MARRS) binding protein stimulates signal transduction to increase calcium uptake |
Nongenomic function of Calcitriol |
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Vitamin D in nucleus acts as hormone by binding the vitamin D nuclear receptor (VDR) |
Genomic function of Calcitriol |
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1,25-OH D is known as |
Calcitriol |
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In the kidney Calcitrol increases the transcription of ____ |
Calbindin D28K |
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Vitamin D is used in the treatment of ___ condition in which differentiation of keratinocytes is reduced and proliferation is increased |
Psoriasis |
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Calicitriol decreases the expression of ___ and therefore Ang II levels and BP |
Renin |
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25-OH decreases ____ increases ____, thus decreasing risk of heart disease |
LDL, HDL |
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Symptoms of Rickets |
Bowed legs, spinal, pelvic, thoracic deformities |
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Vit D deficiency in adults = soft bones |
Osteomalacia |
