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54 Cards in this Set

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Picorna
RNA is translated into 1 large polypeptide that is cleaved by proteases into functional viral proteins
can cause aspetic meningitis
Rotavirus MOA
villous destruction with atrophy leads to decreased absorption of Na and water
Mumps
parotitis (increased amylase), orchitis (inflammation of testes), aseptic meningitis
Measles
Cough, coryza, conjunctivitis, koplik spots
Subacute sclerosing panencephalitis
influenza
contains hemagglutin and neuraminidase antigens, winter epidemics
genetic shift
reassortment of viral genome; big deal, deadly
pandemic
genetic drift
minor changes based on random mutation- change in virus every year
epidemic
Treatment of flu
amantidine and rimantidine
Do not give aspirin to kids if...
flu or chickenpox; causes Reye's- mito dysfunction of liver and brain
Rabies
see negri bodies- characteristic cytoplasmic inclusions in neurons
long incubation period
fetal encephalitis with seizures and hydrophobia
travels to CNS retrograde up axons
Yellow fever symptoms
high fever, black vomitus, jaundice
counsilman bodies (acidophilic inclusiosn) may be seen in the liver
HSV1
gingivostomatitis, keratoconjunctivitis, temporal lobe encephalitis, herpes labialis
HSV2
herpes genitalis, neonatal herpes
EBV
infectious mono, Burkitts; respiratory transmission
VZV
shingles, encephalitis, pneumonia; respiratory transmission
CMV
congenital infection, mono, pneumo
enlarged cells with owls eye inclusions
HHV8
Kaposi's
HHV 6
roseola infantum- children with high fever for days, goes away and body breaks out in a rash
may act completely normal
Mono
caused by EBV- infects CD21 B cells, response by T cells (Downy cells- with foamy cytoplasm)
pharyngitis, fever, hepatosplenomeg, LAD
heterophil negative mono
CMV
listeria
toxoplasma
EBV cancer associations
thymic carc
Burkitts
nasopharnygeal carc
Monospot test
heterophil AB detected by agglutination of sheep RBCs (IgM)
EBV mono only
Tzanck test
opened skin vesicle to detect MNGCs
assay for HSV1, HSV2, VZV
HAV
fecal oral
short incubation
no carriers
HBV
parenteral, sexual, maternal-fetal
carriers
reverse transcription occurs; virion enzyme is a DNA dependent DNA pol
HCV
blood; carriers, IV drug abusers
hepatocellular carcinoma
HBV/HCV; monitor AFP
HDV
must have HBV infection, carriers
HEV
enteric transmission; high mortality in pregnant women
HBsAg
active disease
HBsAb
recovered
HBcAg
new disease
HBcAB
history of disease
HBeAg
contagious
Acute disease
HBsAg, HBcAb
Window phase
HBcAb only
Complete recovery
HBsAg, HBcAb
Chronic carrier
HBsAg, HBcAb
Immunized
HBsAb
Reverse transcriptase
synthesizes dsDNA from RNA; dsDNA integrates into host genome
HIV diagnosis
ELISA (rules out), Western blot (rules in)
Viral load test
confirmatory; allow physician to monitor effect of drug therapy on viral load
ELISA/WeBlo limitations
falsely negative in first 1-2 months of infection, falsely positive initially in babies born to infected mothers (anti-gp 120 crosses placenta)
CCR5 mutation
homozygous- immunity
heterozygous- slower course
CXCR1 mutation
rapid progression to AIDS
HIV encephalitis
late in HIV infection; virus gains access to CNS via infected macrophages; microglial nodules with MNGC
Prions
b pleated sheet proteins
if CD 4 < 50
fluconazole to prevent fungal infections
if CD 4 < 200
TMP-SMX or dapsone to prevent PCP
if CD4 < 75
clarithromycin to prevent MAC
hides in trigeminal ganglia
HSV1
hides in doral root ganglia
VZV
hides in sensory ganglia or S2 and S4
HSV2
asthma sounding infection in infants
RSV