Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
75 Cards in this Set
- Front
- Back
|
name DNA viruses
|
Hepadno
Herpes Adeno Parvo Papova Pox |
|
|
qualities of DNA viruses
|
all dsDNA (exc Parvo)
all linear (exc hepadno) all icosahedral (exc Pox) all replicate in nu (exc Pox) |
|
|
name naked DNA viruses
|
Parvo
Adeno Papova |
|
|
name enveloped DNA viruses
|
Hepadno
Pox Herpes |
|
|
qualities of Pox
|
enveloped, dsDNA, linear
complex doesn't replicate in nu (it's own DNA dependent RNA polymerase) |
|
|
qualities Parvo
|
nakes
icosahedral dsDNA circular/supercoiled |
|
|
qualities Hepadno
|
enveloped dsDNA
icosahedral circular incomplete DNA |
|
|
qualities Herpes
|
enveloped, dsDNA linear, icoshedral, replicate in nu, but membrane is from nucleus
|
|
|
the naked DNA of which viruses are infxs
|
all except Pox and Hepadno
|
|
|
Adeno causes
|
febrile pharyngitis, PNA, conjunctivitis (pink eye)
|
|
|
Parvo causes
|
B19-aplastic crisis in SC
erythema infectiosum=5th dz with slapped cheek rash hydrops fetalis |
|
|
papovirus family includes
|
HPV-warts, CIN, cervical cancer
JC-PML in HIV |
|
|
Pox virus causes
|
smallpox
vaccinia (cowpox) molluscum contagiosum |
|
|
RNA viruses w/o envleope
|
Picorna, Calici, Reo
(naked CPR) |
|
|
all viruses ssRNA exc
|
Reo (dsRNA)
|
|
|
RNA viruses all replicate...exc
|
replicate in cytoplasm
exc influenza and retro |
|
|
in family of picorna (and assoc dz)
|
=PERCH
Polio Echo-a. meningitis Rhino-common cold Coxsackie-febrile pharyngitis and hand-foot-mouth Hep A |
|
|
in family of Calici
|
Hep E
Norwalk |
|
|
in family Reovirus
|
Reovirus-Colorado tick fever
Rotavirus-fatal diarrhea in children |
|
|
in family Flavi
|
Hep C
Yellow fever Dengue St Louis encephalitis W. Nile |
|
|
in family Toga
|
Rubella (german measles)
E. equine encephalitis W. equine encephalitis |
|
|
in family Ortho
|
influenza
|
|
|
in familiy Paramyxo
|
PRMM
Parainfluenza-croup (4 sero) RSV-(rx ribavirin) (2 sero) Measles (1 sero) Mumps (1 sero) (all childhood dzs) |
|
|
in family Filovirus
|
Ebola/Marburg-hemorrhagic fever
|
|
|
in family Arenavirus
|
LCV-lymphocytic choriomeningitis
Meningitis-spread by mice |
|
|
in family Bunya
|
CA encephalitis
Sandfly/Rift Valley F Crimean-Congo Hemorr F Hanta-hemorr F, PNA |
|
|
which viruses can immediately start translation
|
+ viruses exc Retro
Picorna Calici Flavi Toga Corona (Reo is DS) |
|
|
Yellow fever is in
|
Flavi
|
|
|
St. Louis encephalitis is in
|
Flavi
|
|
|
Dengue is in
|
Flavi
|
|
|
Sanfly/Rift Valley is in
|
bunya
|
|
|
CA encephalitis is in
|
bunya
|
|
|
crimean-congo is in
|
bunya
|
|
|
hanta is in
|
bunya
|
|
|
rubella is in
|
toga
|
|
|
W,E equine is in
|
toga
|
|
|
measles is in
|
Paramyxo
|
|
|
Ebola/Marburg is in
|
Filo
|
|
|
Hep A is in
|
Picorna
|
|
|
Hep E is in
|
Calici
|
|
|
Hep C is in
|
Flavi
|
|
|
hemorr F can be caused by
|
Ebola/Marbug (Filo)
Hanta, Crimean (Bunya) |
|
|
segmented viruses
|
BOAR
Bunya Ortho Arena Reo |
|
|
which family starts as 1 large polypeptide
|
Picorna
|
|
|
key to dx measles
also look for |
Koplik spots-bluish-gray spots on buccal mucosa
+CCC Cough Coryza Conjunctivitis |
|
|
mumps causes
|
MOP
meningitis orchitis parotitis |
|
|
name some arboviruses
|
flavi
toga bunya |
|
|
yellow fever-transmission, presentation
|
transmitted by Aedes mosquito
hi F, black vomit, jaundice |
|
|
histol finding dx of yellow fever
|
Councilman bodies (acidophilic inclusions in liver)
|
|
|
how influenza causes repeat infxns
|
8 segments of - RNA, when reassort cause antigenic shift
note: flu also deadly bc fatal bac infxns that come after |
|
|
genetic shift v drift
|
shift=reassortment of viral genome-human flu A virus combines w swine flu A
drift=minor changes, random mutation |
|
|
heterophil Ab
|
used to dx Mono (EBV)
Monospot test-heterophil Ab detected by agglutination of sheep RBC |
|
|
histol of mono
|
atypical lymphocytes
|
|
|
transmission Hep B
|
hi risk-
IVDA mltpl partners transfusion/dialysis mother to child low risk razor toothbrush needlestick |
|
|
cxn Hep A
|
fulminant
cholestatic (dep bile, itchy) relaps Hep |
|
|
qualities Mono
|
F, HS, pharyngitis, p auricular LAD
|
|
|
which Toga virus is not an arbo virus
|
Rubella
|
|
|
describe 3 classes of Influenza
|
A=8 seg, 10 viral proteins
B=8 seg, 11 viral proteins C=7 seg, (no NA), 9 viral proteins |
|
|
describe role of influenza proteins
|
hemoglutinin-att to sialic NANA
NA=clips sialic so release M2=proton channel for endosome |
|
|
rx for influenza and where act
|
M2 inhib=Amantadine, Rimant (can't use for B)
NA inhib=Zanamivir |
|
|
extra hep Hep C
|
Sjorgen
globulin abnl vasculitis GN erythema nodosum neuropathy |
|
|
"env" makes HIV
|
gp120, gp41
|
|
|
"gag" makes HIV
|
capsid (p24)
core nuclear capsid matric proteins (p17) |
|
|
"pol" gene makes HIV
|
protease
integrase RT |
|
|
name three impt genes to HIV
|
env, gag, pol
|
|
|
role of gp41
|
fusion
|
|
|
what detect in ELISA for HIV
|
p24 (then confirm with Western)
|
|
|
describe Ab reponse to HIV
|
first: p 24Ag and Ab (but p24Ag can take 1-2 mos)
then: gp120 Ab late: p17, p24 Abs eventually disappear, but envelope (gp41,120) continue (would have negative ELISA) |
|
|
name 2 mutations that give difft course to HIV
|
CCR5=homo=immunity (1% US cauc)
=hetero=slower course (20% US cauc) CXCR1 mutation=rapid progression to AIDS |
|
|
how are pathol prion distinct from normal prions
|
normal=alpha helix
path (CJD)=beta pleated sheet |
|
|
HPV strains assoc GYN cancer? which cancers
|
16, 18
cervical, penile, anal |
|
|
CMV can cause
|
congenital, mono, PNA
|
|
|
VZV can cause
|
zoster, encephalitis, PNA
|
|
|
HSV1 can cause
|
gingiostomatitis, keratoconjunctivitis, temporal lobe encephalitis, herpes labialis
|
|
|
herpes viruses transmitted sexually
|
HSV2, CMV, HHV-8 (HSV and EBV by saliva/respir)
|
