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75 Cards in this Set

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name DNA viruses
Hepadno
Herpes
Adeno
Parvo
Papova
Pox
qualities of DNA viruses
all dsDNA (exc Parvo)
all linear (exc hepadno)
all icosahedral (exc Pox)
all replicate in nu (exc Pox)
name naked DNA viruses
Parvo
Adeno
Papova
name enveloped DNA viruses
Hepadno
Pox
Herpes
qualities of Pox
enveloped, dsDNA, linear
complex
doesn't replicate in nu (it's own DNA dependent RNA polymerase)
qualities Parvo
nakes
icosahedral
dsDNA
circular/supercoiled
qualities Hepadno
enveloped dsDNA
icosahedral
circular
incomplete DNA
qualities Herpes
enveloped, dsDNA linear, icoshedral, replicate in nu, but membrane is from nucleus
the naked DNA of which viruses are infxs
all except Pox and Hepadno
Adeno causes
febrile pharyngitis, PNA, conjunctivitis (pink eye)
Parvo causes
B19-aplastic crisis in SC
erythema infectiosum=5th dz with slapped cheek rash
hydrops fetalis
papovirus family includes
HPV-warts, CIN, cervical cancer
JC-PML in HIV
Pox virus causes
smallpox
vaccinia (cowpox)
molluscum contagiosum
RNA viruses w/o envleope
Picorna, Calici, Reo
(naked CPR)
all viruses ssRNA exc
Reo (dsRNA)
RNA viruses all replicate...exc
replicate in cytoplasm
exc influenza and retro
in family of picorna (and assoc dz)
=PERCH
Polio
Echo-a. meningitis
Rhino-common cold
Coxsackie-febrile pharyngitis and hand-foot-mouth
Hep A
in family of Calici
Hep E
Norwalk
in family Reovirus
Reovirus-Colorado tick fever
Rotavirus-fatal diarrhea in children
in family Flavi
Hep C
Yellow fever
Dengue
St Louis encephalitis
W. Nile
in family Toga
Rubella (german measles)
E. equine encephalitis
W. equine encephalitis
in family Ortho
influenza
in familiy Paramyxo
PRMM
Parainfluenza-croup (4 sero)
RSV-(rx ribavirin) (2 sero)
Measles (1 sero)
Mumps (1 sero)
(all childhood dzs)
in family Filovirus
Ebola/Marburg-hemorrhagic fever
in family Arenavirus
LCV-lymphocytic choriomeningitis
Meningitis-spread by mice
in family Bunya
CA encephalitis
Sandfly/Rift Valley F
Crimean-Congo Hemorr F
Hanta-hemorr F, PNA
which viruses can immediately start translation
+ viruses exc Retro
Picorna
Calici
Flavi
Toga
Corona
(Reo is DS)
Yellow fever is in
Flavi
St. Louis encephalitis is in
Flavi
Dengue is in
Flavi
Sanfly/Rift Valley is in
bunya
CA encephalitis is in
bunya
crimean-congo is in
bunya
hanta is in
bunya
rubella is in
toga
W,E equine is in
toga
measles is in
Paramyxo
Ebola/Marburg is in
Filo
Hep A is in
Picorna
Hep E is in
Calici
Hep C is in
Flavi
hemorr F can be caused by
Ebola/Marbug (Filo)
Hanta, Crimean (Bunya)
segmented viruses
BOAR
Bunya
Ortho
Arena
Reo
which family starts as 1 large polypeptide
Picorna
key to dx measles
also look for
Koplik spots-bluish-gray spots on buccal mucosa
+CCC
Cough
Coryza
Conjunctivitis
mumps causes
MOP
meningitis
orchitis
parotitis
name some arboviruses
flavi
toga
bunya
yellow fever-transmission, presentation
transmitted by Aedes mosquito
hi F, black vomit, jaundice
histol finding dx of yellow fever
Councilman bodies (acidophilic inclusions in liver)
how influenza causes repeat infxns
8 segments of - RNA, when reassort cause antigenic shift
note: flu also deadly bc fatal bac infxns that come after
genetic shift v drift
shift=reassortment of viral genome-human flu A virus combines w swine flu A
drift=minor changes, random mutation
heterophil Ab
used to dx Mono (EBV)
Monospot test-heterophil Ab detected by agglutination of sheep RBC
histol of mono
atypical lymphocytes
transmission Hep B
hi risk-
IVDA
mltpl partners
transfusion/dialysis
mother to child

low risk
razor
toothbrush
needlestick
cxn Hep A
fulminant
cholestatic (dep bile, itchy)
relaps Hep
qualities Mono
F, HS, pharyngitis, p auricular LAD
which Toga virus is not an arbo virus
Rubella
describe 3 classes of Influenza
A=8 seg, 10 viral proteins
B=8 seg, 11 viral proteins
C=7 seg, (no NA), 9 viral proteins
describe role of influenza proteins
hemoglutinin-att to sialic NANA
NA=clips sialic so release
M2=proton channel for endosome
rx for influenza and where act
M2 inhib=Amantadine, Rimant (can't use for B)
NA inhib=Zanamivir
extra hep Hep C
Sjorgen
globulin abnl
vasculitis
GN
erythema nodosum
neuropathy
"env" makes HIV
gp120, gp41
"gag" makes HIV
capsid (p24)
core nuclear capsid
matric proteins (p17)
"pol" gene makes HIV
protease
integrase
RT
name three impt genes to HIV
env, gag, pol
role of gp41
fusion
what detect in ELISA for HIV
p24 (then confirm with Western)
describe Ab reponse to HIV
first: p 24Ag and Ab (but p24Ag can take 1-2 mos)
then: gp120 Ab
late: p17, p24 Abs eventually disappear, but envelope (gp41,120) continue
(would have negative ELISA)
name 2 mutations that give difft course to HIV
CCR5=homo=immunity (1% US cauc)
=hetero=slower course (20% US cauc)

CXCR1 mutation=rapid progression to AIDS
how are pathol prion distinct from normal prions
normal=alpha helix
path (CJD)=beta pleated sheet
HPV strains assoc GYN cancer? which cancers
16, 18
cervical, penile, anal
CMV can cause
congenital, mono, PNA
VZV can cause
zoster, encephalitis, PNA
HSV1 can cause
gingiostomatitis, keratoconjunctivitis, temporal lobe encephalitis, herpes labialis
herpes viruses transmitted sexually
HSV2, CMV, HHV-8 (HSV and EBV by saliva/respir)