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44 Cards in this Set
- Front
- Back
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VP-16
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HSV: Turns on alpha (immediate early) genes - part of virion
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Zebra (Zta)
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EBV: triggers end of latency
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LMP-1
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EBV: immortalizes cell
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EBNA-1
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EBV: stabilizes vDNA in episomal state
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HSV
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LAT: ?
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E1A
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Adeno: binds Rb
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E1B
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Adeno: binds p53
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NS
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Parvo: non-structural Rep protein -> cutting & unwinding of vDNA
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CAP
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Parvo: structural
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E6
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HPV: binds p53
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E7
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HPV: binds Rb
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E1
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HPV: DNA binding protein
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E2
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HPV: transcription factor
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E4
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HPV: late expressed (?)
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large T
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SV40/Polyoma: Binds p53/pRb
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middle T
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Polyoma: Binds c-src
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small T
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SV40/polyoma: Binds protein phosphatase 2A
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VP4
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Rota: Outer capsid protein, cleavage -> infectious
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NS1
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Flavi: Express on infected cell surface, secreted
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Pre-S1
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HepB: Binds cell receptor, mediates entry
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core
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HepB: HBcAg + polymerase + DNA
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envelope
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HepB: HBsHg (pre-S1 + pre-S2)
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M
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Paramyxo: Budding
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HN
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Paramyxo: Hemagglutinin-neuraminidase (SA binding, measles lacks N)
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F
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Paramyxo: Fusion (cleavage->infectious)
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L
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Paramyxo: RdRP
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P
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Paramyxo: phosphorylation protein (needed for polymerase)
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E1/E2
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Rubella: Envelope proteins
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Vpg protein
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Picorna: 5' protein (3' is poly A)
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VP 0,1,2,3,4
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Picorna: Promoter proteins, 0=2+4, 4 is internal
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protease 2A
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Picorna: disrupts cellular Ribosomes (also 3C does something)
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gag
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HIV: core/capsid [p21,p17,p9,p7]
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pol
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HIV: RevTrans, Int, Prot
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env
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HIVL: envelope [gp120, gp41]
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HA
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Orthomyxo: Hemagglutinin - receptor binding, cleavage -> infectivity
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NA
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Orthomyxo: Neuraminidase - relasee of virus from cell
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NP
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Orthomyxo: Nucleocapsid - manage RNA synthesis mode
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PB1
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Orthomyxo: Catalyzes nucleotide addition (part of Poly)
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PB2
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Orthomyxo: binds mRNA
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M1
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Orthomyxo: Matrix protein (cell transport)
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M2
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Orthomyxo: M2 - ion channel
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NS-1
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Orthomyxo: inhibit mRNA export, RNA splicing of host
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tax
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HTLV: trans-activator
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rex
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HTLV: accessory gene
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