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44 Cards in this Set

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VP-16
HSV: Turns on alpha (immediate early) genes - part of virion
Zebra (Zta)
EBV: triggers end of latency
LMP-1
EBV: immortalizes cell
EBNA-1
EBV: stabilizes vDNA in episomal state
HSV
LAT: ?
E1A
Adeno: binds Rb
E1B
Adeno: binds p53
NS
Parvo: non-structural Rep protein -> cutting & unwinding of vDNA
CAP
Parvo: structural
E6
HPV: binds p53
E7
HPV: binds Rb
E1
HPV: DNA binding protein
E2
HPV: transcription factor
E4
HPV: late expressed (?)
large T
SV40/Polyoma: Binds p53/pRb
middle T
Polyoma: Binds c-src
small T
SV40/polyoma: Binds protein phosphatase 2A
VP4
Rota: Outer capsid protein, cleavage -> infectious
NS1
Flavi: Express on infected cell surface, secreted
Pre-S1
HepB: Binds cell receptor, mediates entry
core
HepB: HBcAg + polymerase + DNA
envelope
HepB: HBsHg (pre-S1 + pre-S2)
M
Paramyxo: Budding
HN
Paramyxo: Hemagglutinin-neuraminidase (SA binding, measles lacks N)
F
Paramyxo: Fusion (cleavage->infectious)
L
Paramyxo: RdRP
P
Paramyxo: phosphorylation protein (needed for polymerase)
E1/E2
Rubella: Envelope proteins
Vpg protein
Picorna: 5' protein (3' is poly A)
VP 0,1,2,3,4
Picorna: Promoter proteins, 0=2+4, 4 is internal
protease 2A
Picorna: disrupts cellular Ribosomes (also 3C does something)
gag
HIV: core/capsid [p21,p17,p9,p7]
pol
HIV: RevTrans, Int, Prot
env
HIVL: envelope [gp120, gp41]
HA
Orthomyxo: Hemagglutinin - receptor binding, cleavage -> infectivity
NA
Orthomyxo: Neuraminidase - relasee of virus from cell
NP
Orthomyxo: Nucleocapsid - manage RNA synthesis mode
PB1
Orthomyxo: Catalyzes nucleotide addition (part of Poly)
PB2
Orthomyxo: binds mRNA
M1
Orthomyxo: Matrix protein (cell transport)
M2
Orthomyxo: M2 - ion channel
NS-1
Orthomyxo: inhibit mRNA export, RNA splicing of host
tax
HTLV: trans-activator
rex
HTLV: accessory gene