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7 Cards in this Set
- Front
- Back
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How are prions different from viruses?
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No nucleic acid genome or capsid structure
Prions are not inactivated by formaldehyde, protease, heat, or UV, but viruses are. Prions can have a very long incubation period. |
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What are the differences between normal and scrapie prion proteins?
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The abnormals have more beta sheets. They are not sensitive to protease, and localize to the cytoplasm instead of the plasma membrane.
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What diseases are caused by prions?
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vCJD, Kuru
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What diseases are caused by animal prions?
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Scrapie, mink encephalopathy, BSE, chronic wasting disease of deer and elk, and feline enceph
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Who is at risk of prion infection?
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People that are in direct contact with animals that have prion disease. There is a link between BSE and vCJD.
Transmission possible with surgical instruments and contaminated vaccines. |
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How can you test for the presence of prion diseases?
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Histology (post mortem)
Detection of PrPres in the brain by IHC, WB, or ELIZA (post mortem) Tonsillar biopsy for vCJD Western blot for protease resistance |
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How do you treat prions?
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No treatment available
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