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58 Cards in this Set
- Front
- Back
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What indicator is diagnostic of recovery from acute hepatitis caused by hepatitis B
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Anti-Hbs IgG
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What is an approved and effective therapy for RSV infection in the young and in bone marrow transplant recipients
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Treatment with a polyclonal anti-RSV IgG
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How might disease be prevented from rabies virus
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Active and passive immunization
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What type of viral vaccine is most likely to induce cytotoxic T lymphocyte activity
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Live attenuated virus vaccine
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The tumor suppressors targeted by DNA viruses regulate what cellular process
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Cell cycle progression
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What viral gene is most likely to be mutated in influenza viruses that are resistant to rimantidine
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M2 ion channel gene
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What virus establishes latent infection in humans
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Epstein-Barr virus
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The humanized monoclonal antibody preparation developed as a prophylactic therapy for RSV infection is directed against what viral protein
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The F glycoprotein
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In what virus is viremia an important event in the pathogenesis
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Measles virus
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What serological indicator in a person predicts development of fulminant hepatitis after infection by hepatitis D
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HbeAg
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A 40 year old woman with a 2 year history of HIV infection presented with Stage IV squamous cell carcinoma of the cervix. What is the cancer most likely caused by
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Human papilloma virus
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A large outbreak of acute respiratory disease (ARD) occurred at Fort Jackson, South Carolina, in 1997. Members of the virus family to which the causative agent of ARD belong can also cause what disease
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Gastroenteritis
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Some of the nucleoside analogs used to inhibit HIV replication may also be efficacious against what virus
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Hepatitis B virus
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Severe Shock Syndrome after re-infection is caused by a virus that belongs to what family
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Flaviruses. Dengue and Hepatitis C are flavorful viruses
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The appearance of drug-resistant variants of a virus is most likely to develop due to what
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Patients chronically treated with sub-optimal doses of a drug
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What is the target of Zanamivir (Relenza), the newly approved drug for influenza virus infection
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Neuraminidase
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What would be the best treatment for a bite wound from a raccoon in New Jersey on the hand of an unvaccinated individual
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Wound cleansing, administration of anti-rabies immunoglobulin, and vaccination
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What is the number one military mission-aborting viral disease
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Dengue virus
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How are the majority of new HIV-1 infections transmitted on a global scale
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Heterosexual sex
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What makes Poxviruses exceptional
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They are DNA viruses that can replicate in the cytoplasm
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What does type 1 interferon do
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Inhibits mRNA translation
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A 27-year-old female who contracts human papilloma virus type 16 is at risk for developing what
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A chronic active viral infection
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A positive result from an HIV-1 ELISA assay would most likely be verified by what assay
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Western Blot
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Viremia occurs following infection with which one of the following viruses?
(A) Human papilloma virus (B) Influenza A virus (C) Norwalk virus (D) Rotavirus (E) West Nile virus |
E, West Nile virus
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Progressive multifocal leukoencephalopathy (PML) in AIDS patients is caused by a virus that belongs to what family
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Papova viruses. Human papilloma virus is another example
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Which one of the following is an important goal for viral vaccine development today?
(A) A killed oral vaccine for VZV (B) A killed trivalent vaccine for measles, mumps, and rubella (C) A live-attenuated viral vaccine for hepatitis B virus (D) A recombinant protein-subunit vaccine for poliovirus (E) A vaccine for RSV and human parainfluenza type 3 ANS: |
E, a vaccine for RSV md human parainfluenza type 3
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The viral oncogene, v-src, of Rous sarcoma virus encodes what
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Tyrosine kinase
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Children undergoing chemotherapy can be given immunoglobulins for certain common childhood diseases such as chickenpos (VZV). What is this procedure and example of
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Passive immunization
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What is AIDS defined by
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CD+4 T cell count is less than 200 per mm3 and opportunistic infections are present
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What is Hanta virus pulmonary syndrome transmitted by
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Deer mice
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The current poliovirus vaccine recommended for healthy children in the US is what type of vaccine
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Killed virus vaccine
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What is an important and immediated concern to the hospital staff with a newborn that has been diagnosed with congenital rubella syndrome
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The high probability that the child is excreting infectious virus
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What do the envelope glycoproteins of HIV-1 and HIV-2 do
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They bind to cellular receptors and mediate membrane fusion at the cell-surface
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What type of antibody is diagnostic of an acute primary viral infection
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Anti-virus IgM antibody
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Which one of the following viruses is inactivated following chloroform treatment?
(A) Hepatitis A virus (E) Human papilioma virus (C) Measles virus (D) Poliovirus (E) Rotavirus ANS: |
C. Measles virus
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Immediately after viral entry, what happens to the RNA genome of mumps virus
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It is copied into anti-genome RNA by the viral RNA polymerase
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Clinical manifestations of military relevant arboviral infections present in 4 major categories. Which form of infectious presentation is most common
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Asymptomatic or subclinical
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How may suspected CMV infection in immune compromised patients with pneumia be quickly verified in the laboratory
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By testing for viral early antigens in cultured cells infected with respiratory aspirates by immunofluorescence
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A 9-year-old girl was involved in a traffic accident and suffered from traumatic damage to the left kidney and diaphragm and received a pelvic bone fracture. At emergency surgery she was transfused with 1200 ml of fresh whole donor blood. She was hospitalized and abnormal liver function was observed 10 days after surgery. Serology at this time indicated that she was positive for HBsIgG. The histology of liver biopsy at 23 weeks after operation showed the findings of acute hepatitis. What virus is most likely to be the cause
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Cytomegalovirus
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Two kidney transplant recipients developed symptomatic anemia requiring blood transfusions. Common causes of anemia, such as gastrointestinal bleeding, iron vitamin deficiencies, hemolysis, and drug toxicities, were ruled out. A peripheral smear revealed low reticulocyte count. Bone marrow examination showed hypoplastic bone marrow with intranuclear inclusions, suggestive of viral infection. What virus is most likely to be the cause of the disease
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Parvovirus B19
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A 33-year-old pregnant woman delivered a baby boy via a normal vaginal delivery. Neither she nor the father has a history of genital or oral herpes. She had chickenpox as a child and was exposed to a child with chickenpox about 10 days before delivery. There was no
evidence of vesicular skin lesions on either the mother or the child at the time of delivery. Three days afier birth, the baby developed vesicular skin lesions on his back, accompanied by a fever. What virus is most likely to be the cause of the baby's infection |
Herpes simplex virus type 2
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You are stationed in Japan. A 3112-month-old male presents in August with a history of
diarrhea and fever. On physical examination, he is irritable and has tachycardia with a pulse of 180 beatslmin. Vesicular lesions are observed on his mouth, hands and feet. The virus responsible for the disease (A) causes chronic and persistent infection. (B) causes latent infection. (C) contains a segmented RNA genome. (D) contains a single-stranded RNA genome that is infectious. (E) replicates in the nucleus of an infected cell.«3 |
D contains a single-stranded RNA genome that is infectious
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An outbreak of a respiratory virus disease in chickens occurred in Hong Kong in 1998. This
virus was transmitted to the human population, resulting in several deaths. What is responsible for the emergence of epidemic outbreaks caused by this virus |
Reassortment of viral genome segments in animal hosts
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A 42-yr-old Haitian-American woman was diagnosed with T-cell leukemia. According to her sister, their deceased mother breast-fed all the children. The sister of the patient also reported that their mother had suffered from progressive difficulty walking over a period of several years, and was finally unable to walk. The 38-year-old brother of the patient had also developed paralysis of the lower limbs 2 years previously. The leukemia cells of the patient
are MOST LIKELY to be (A) CD4-positive. (B) CD8-positive. (C) infected with HHV-8. (D) infected with HIV. (E) transfornled by HPV- 16. ANS: |
A, CD4-positive
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A 17-year-old high school girl presents to your office with cervical lymphadenopathy, a sore throat, and fever. On her peripheral blood smear, you notice an atypical lymphocytosis.
Physical examination of her abdomen shows an enlarged spleen. The virus responsible for her condition can also cause what type of cancer |
Nasopharyngeal carcinoma
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A 30-year-old male patient presented to the clinic with jaundice, malaise, weakness and nausea. He related a two month-long illness with the same symptoms. His blood tests revealed the presence of a high level of hepatitis B surface antigen and high titers of antibodies against
hepatitis B core antigen. What does this mean |
He is acutely infected by hepatitis B virus
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Ten servicemen report to your infirmary on a Monday morning complaining of mild fever,
nausea, vomiting and in some individuals, diarrhea. They had all attended a local bar and grill the previous Saturday night where the evening's special was peel-n-eat shrimp. Their symptoms abate approximately 24 hours after you see them. Which viral agent is the MOST LIKELY cause of this episode? |
Norwalk Virus
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The world-wide eradication of smallpox results from of all of the following factors EXCEPT
(A) An effective and stable vaccine was available. (B) Smallpox disease was readily identifiable in the field. (C) The effectiveness of the surveillance-containment strategy. (D) The existence of only one viral serotype. (E) The presence of only 2 animal reservoirs. ANS: |
E, The presence of only 2 animal reservoirs.
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Live attenuated virus vaccines are used for all of the following viral diseases EXCEPT
(A) chickenpox. (B) hepatitis B. (C) measles. (D) mumps. (E) rubella. ANS: |
B, hepatitis B.
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Cytopathic effect (CPE) is easily measured in tissue culture in all of the following viruses
EXCEPT (A) enterovirus 7 1. (B) herpes simplex vin~tsy pe 2. (C) HIV-1. (D) respiratory syncytial virus. (E) rubella virus. ANS: |
E, rubella virus
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All of the following diseases are thought to be caused by prions EXCEPT
(A) Bovine spongiform encephalopathies. (B) Creutzfeldt-Jakob disease. (C) Kuru. (D) Scrapie. (E) Subacute sclerosing panencephalitis (SSPE). ANS: |
E, Subacute sclerosing panencephalitis (SSPE).
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A newborn baby presenting with heart murmur and cataracts is associated with what virus
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Rubella virus
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A newborn presenting with hepatosplenomegaly, jaundice, and petechial rash is associated with what virus
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CMV
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CD4+ T cell depletion is associated with what virus
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HIV-1
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What virus is associated with no viremia and giant cells are present in the lung
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RSV
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What would be the treatment for an animal technician that has been bitten by a herpse B-infected monkey
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Acyclovir
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What would be the treatment for an HIV infected individual with CMV retinitis
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Ganciclovir
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What would be the treatment for a 30 year old woman with chronic hepatitis C infection
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Interferon plus ribavirin
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