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18 Cards in this Set

  • Front
  • Back
the basic structure of human viruses
1. icosahedral
2. helical
3. complex
4. obligate intracellular parasites
5. chemical makeup-DNA OR RNA (ss or ds)
6. capsid (made of capsomeres); gycloprotiens, phsophorprotens
7. nucleoocapisid : capsid +nucleic acid core
8. lipid envelopes (or are naked)
obligate intracellular parasite
doesn't divide; no ability to make more of them o/side cell; genetic bombs
can be naked & envelope viruses; 12 points/20 sides/very stable
MOST nucleic acid/prtoein subnuis assoicated w/nuclic acids/asmelbe in anature into helicals
only POX virus has this shape/has a central dense area called a nuclosome with lateral bodies that contrain ribsomes and trna's
Are human virus naked?
No, have envelope
2. the nature of viral replication
Relates to pathogenieis:
1. adsorption--->attachment
2. penetration...>endocytosis or fusion
3. uncoating...>release n.acid..either goes into mRNA or DNA (n.acid to ncls)
4. biosynthesis..viral gene expression: bomb explodes
5. maturation and release..simple cell autolysis or evagination
how do naked viruses get into cells verses envelope viruses?
1. naked-engulfment; invagination all cells capable of this
2. infusion- envelope viruses-get in-outer membrane mocks cell membrane and fuses w/this-
3. factors that lead to viral pathogenesis?
1. cell destruction-by inhibition of host DNA, RNA and or/protein synthesis (immune evasion)
2. transformation-cancer viruses
3. Latent or peristant infection-dormant (herpes)/persistnat viruses have very slow growth rates so no immune response-adenovirus
4. immune mediated-causes the SYMPTOMS of viurs; arthirists
5. imune evasion
6. subclinical or inapparent-2nd time of virus intrdouction/naturally immune
There are 7 classes of virus : name ex and imp ones
2. ssDNA
3. dsRNA
4. ss+RNA-Hep C; where geonme is mRNA
5. ssRNA-influezna
6. ssRNA-uses reverse transciption-dsDNA-cromsomal intergration-HIV
7. dsDNA-Hep B-usues reverse transcitpion
5 effects of immune evasion:
1. infection & destructio of immune cells (HIV +CD4 cells)
2. block MHC I and II, presentation of viral antigens
3. blocks production or activation of complement, cytokines, interferon
4. prevents proliferaton of activated T-cells; stimulates production of null cells
5. antigenic variation (mutation)
4. Epidemoiological consideration w/respect to the transmission and dissemaination of viral diseases
Transmitted by:
1. person to person
2. blood
3. vectors--mosquitos
4. food/water
Dissemantiaon factors?
1. age-newborn/ped/adult?
2. gender
3. geographic distribution (local.Us. world)
4. prevlance-local,
Basic methods of viral identification:
1. clinical symptoms-pt interivew and hx
2. diagnositic tests: v.isolation (rare); serologic-elisa,wb, n.acid, hybrid capture, sens &spec
6. the availabity of treatments or preventatives for this disease?
1. treametnments: antivirals target inhibition of n.acid synthesis inhibition
2. prevention: vaccination, repellants, barriers
3 types of viral vaccines:
1. inactivated-by heat, UV-POLIO
2. live, attentuated--MEASLES, MYMPS< RUBELLA
3. Subunit-dsrupted virus, recbominbant DNA--HEPATTITS B (flu can be any of the three types)
alternatives to the primary disease manifestations of viral disease:
1. latent=herpes
2. peristant=adeno
3. mutation=flu
4. abundance of substrains=rhino
5. oncogenic-papilloma
6.evading immune system-HIV
7. subviral=prion
8.animal resovir/bioterriosm
Ex of how different diseases can present different clinically:
1. koplick spots-white spots on buccal mucosa-measles
2. giant multinucleated-genital herpes
3. councilman bodies-yellow fever
4. negri bodies-rabies