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9 Cards in this Set
- Front
- Back
Influenza target cells
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respiratory tract
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What are the two types of anti-viral drugs?
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1. Virus uncoating inhibitors (amantidine, rimantidine)
2. Viral NA inhibitors (tamiflu) |
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When were the three major flu pandemics and what strains were they?
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1918 H1N1
1957 H2N2 1968 H3N2 (still active) |
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What protein do all non-segmented minus strand viruses encode?
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RNA - dep RNA polymerase. encapsidated in the virion
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What compartment do all minus strand viruses replicate in?
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cytoplasm
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What specific protein is used by influenza to bypass your immune response?
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NS1 - disrupts interferon pathway that blocks translation
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Who invented the IPV polio vaccine? What are the pros/cons?
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Salk
Could revert back to virulent strain. SV40 contamination. Requires trained medical personnel;. |
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Who invented the OPV polio vaccine? What are the pros/cons?
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Sabin
Responsible for the herd effect. Problems include a slight risk of paralysis. |
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What are polio's strategies to overcome host immune response?
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2Apro and 3Cpro viral proteases cleave cell’s eIF4G (cap-binding protein). This prevents the host machinery from translating capped mRNA.
Dephosphorylation of 4EBP1 allows it to bind to eIF4e. Once bound, this prevents eIF4E from binding to eIF4G, which is used for translation. |