Virology

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genetic variability in HIV is due to:

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envelope protein genes

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foamy, lace-like appearance with syncytium formation

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spumavirus-part of lentivirus fam. (note: doesn't cause cx. or any disease)

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binds LTRs and upregulates transcription in HIV

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Tat gene

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regulates expression of viral mRNA so that structural genes are turned on (HIV)

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Rev gene

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downregulates host immune response in HIV

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Nef gene

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p24

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comprises the core protein of the capsid for HIV; encoded by the gag gene

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CT/MRI changes

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JC polyoma virus ID

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plantar and common wart

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HPV 1 and 2

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condylomata and laryngeal warts

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HPV 6 and 11

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anogenital malignancy and other pre-malignant warts

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HPV 16 and 18

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most common viral std

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HPV

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E6

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degrades p53 in papillomavirus

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E7

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inhibits Rb in papillomavirus

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HPV 11

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oral/laryngeal warts and genital warts (condylomata)

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HPV 16

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anogenital malignancies

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HPV 18

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anogenital malignancies

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HPV 2

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common wart

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HPV 1

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common wart

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HPV 6

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condylomata and laryngeal warts

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2nd most common malignancy in females

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cervical cx

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dx of HPV

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pap smear, dna hybridization or PCR, Ab's against HPV DNA

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CIN Grading System

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used in cervical biopsy; based on degree of dysplasia in the basal layer of cells at the squamous-columnar jxn in the cervix

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ASCUS, LGSIL, HGSIL

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system used with interpreting a pap smear; ASCUS = atypical cells present so do a HPV DNA test; LG = low grade

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VLP

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virus like particle-used to create the HPV vaccine

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CAR

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receptor on host cell for coxsackie and adenovirus

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adenovirus type that causese Acute Respiratory Illness

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1, 2, 3, 4, 5, 7, 10, 11, 13, 14, 21

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adenovirus type that causes gastroenteritis

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40, 41

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military recruit and acute respiratory distress

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adenovirus 14 is the major one

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erythema infectiosum

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parvovirus B19-slapped face appearance

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aplastic crisis

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parvovirus B19-B19 infx of an ICd pt causes them to have bone marrow suppression

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hydrops fetalis

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parvovirus B12

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arthritis in young adults

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parvovirus B12

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HSV 1

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cold sores

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2nd most common cause of corneal blindness

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HSV 1

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LATs

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HSV 1 and 2-genes expressed only during the latency period of infection

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gB

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HSV-binds heparin sulfate and mediates initial attachment

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gC

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HSV-binds C3 and prevents opsonization

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gD

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HSV-binds specific receptors involved in cell-cell contacts and signaling

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gE

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HSV-works with gI to bind to IgG to evade the immune system

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gH and gL

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HSV-form a complex and mediate fusion

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VP16

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HSV-tegument protein transported to the nucleus of epithelial cells and causes them to turn on transcription of immediate early genes

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immediate early genes

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HSV-regulatory genes that allow virus to take over the host

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MC congenital infection

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CMV

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MC cause of infx in transplant pt

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CMV

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retinitis and pneumonia in a newborn

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CMV

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roseola

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HHV 6 and 7

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Infects erythroid progenitor cells

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parvovirus

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erythema infectiosum

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parvovirus; "slapped face"

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Parvovirus Sx in Young Adult

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RA

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Parvovirus Sx in Child

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Hepatitis

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Parvovirus Sx in HIV Pt

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Idiopathic RBC Aplasia

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Parvovirus Sx. in Sickle Cell Pt

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Aplastic crisis

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E1A

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Adenovirus; similar to E7 on HPV thrf it binds Rb

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E1B

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Adenovirus; similar to E6 on HPV thrfr binds p53

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#3 cause of pediatric diarrhea

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adenovirus 40, 41

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largest virus

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poxvirus

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molluscum contagiosum

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poxvirus

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keratoconjunctivitis

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adenovirus 8, 19 and HSV 1

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pharyngo-conjunctivitis

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adenovirus

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ARD

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adenovirus; military recruit

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#1 infectious agent in transplant pt

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CMV

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mono

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CMV or EBV

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most common congenital infx

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CMV

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reservior for EBV

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memory B cells

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which virus causes problems only when it comes out of latency

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EBV

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roseola

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HSV 6 and 7

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HSV 6 and 7

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roseola

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guanieri body

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poxvirus-molluscum contagiosum

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post-transplant mono

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CMV

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AIDS pt. w/ mono

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CMV

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MC infx. in transplant pt.

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CMV

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CMT tx.

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gancyclovir

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retinitis

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CMV

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herpangina

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Grp A Coxsackie

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hand, foot, and mouth disease

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Grp A coxsackie; rash

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myocardial infection

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Grp B coxsackie

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black vomit

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yellow fever

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17D vaccine

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yellow fever vaccine-live attenuated

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croup

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Parainfluenza Types 3 and 1; child barks like a dog

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binds to sialic acid

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influenza

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binds to NANA

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influenza

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influenza type assoc. with pandemic

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Type A

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cilia denudition that sets stage for s. pneumo infx.

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influenza virus

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San Joachin Valley virus

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California encephalitis

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Upper Midwest virus

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LaCrosse encephalitis

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SW USA virus

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Hantavirus-causes severe pulmonary infx