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54 Cards in this Set
- Front
- Back
- 3rd side (hint)
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What Baltimore group do baculoviruses belong to? |
1- dsDNA |
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How big is the genome of a baculovirus? |
90 000 - 230 000bp |
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How long is the baculovirus nucleocaspid? |
450nm |
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What is the general shape of baculoviruses? |
Pleomorphic around a brick shape |
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What are the genuses of baculoviruses? |
Granuloviruses, nucleopolyhedralviruses |
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How many virus bodies are occluded by a granulovirus? |
1 |
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What is the matrix protein of granuloviruses? |
Granulin |
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What are other terms for the granulo occlusion bodies? |
Granules, capsules |
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How many virus bodies are occluded by a nucleopolyhedralvirus? |
Many |
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What is the matrix protein of nucleopolyhedralvirus? |
Polyhedrin |
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What are peplomers? |
Viral proteins which form surface projections on host membranes |
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What is GP64? |
Glycoprotein - 64 000 Da |
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What is the function of GP64? |
Allows entry into new cell, aids attachment to vesicle wall |
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What is cathespin? |
General protease |
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What is chitinase? |
Dissolves insect skeleton allowing virus out |
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In what form do baculoviruses travel in the host cell? |
Budding virus |
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Are picorna viruses enveloped? |
No |
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Describe the internal structure of a picornavirus. |
Icosahedral |
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What Baltimore group do picornaviruses belong to? |
IV, +ssRNA |
+ssRNA |
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How big is the picornavirus genome? |
7-8kb, 10-11 genes |
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Give an example of a picornavirus |
Poliovirus |
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What is VP1 used for by the picorna virus? |
Receptor binding |
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Which picornavirus protein acts as a plug to allow RNA to leave the virion? |
VP4 |
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What are VP2 and VP3 used for? |
3 fold symmetry points |
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What is 2A? |
Proteinase - cleaves elF4G |
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What do 2BC do? |
Cause production of lipid membranes and prevention of protein secretion |
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What is 3AB? |
Polyprotein |
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What is 3CD? |
Proteinase |
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Describe the structure of B-jellyroll folds. |
2x 4-stranded B-sheets with 2a-helices at 1 end |
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What substitutes elF4G? |
Internal ribosome entry site |
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What prevents translation of mRNAs? |
7mG cap and poly A tail |
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What Baltimore group do poxviruses belong to? |
1 - ds DNA |
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How big is the small pox genome? |
250 000bp |
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What does vaccinia virus L1 bind to? |
Integrin and laminin receptors |
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What do vaccinia viral particles ride on? |
Actin comet tails |
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How does vaccinia virus leave the cell? |
Budding |
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How many vaccinia viral proteins form the entry complex? |
8 |
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Which 2 proteins are not needed to form the assembly complex but are required for entry? |
9th (F9) and 10th (I2) |
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Where does transcription of the vaccinia virus take place? |
Cytoplasm |
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Which 4 vaccinia viral enzymes are used to cap viral mRNA? |
Terminal phosphatase; Guanylyltransferase; N7-methyltransferase; 2'-O-methyltransferase |
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What is the shape of flaviviruses? |
Pleomorphic |
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What is the internal structure of a flavivirus? |
Icosahedral |
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Are flaviviruses enveloped? |
Yes |
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What Baltimore group do flaviviruses belong to? |
4, +ssRNA |
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How big is the flavivirus genome? |
11kb, 3400 AA |
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How are flaviviruses transmitted? |
Vector borne |
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What term describes the replication of flaviviruses? |
Asymmetric, semi-conservative |
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Describe the M protein? |
Membrane protein, embedded |
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What is another name for prM? |
Furin |
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Describe prM |
Intracellular, N-terminus extensions |
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What is the function of TGN? |
Cleaves prM |
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What is E? |
Envelope protein |
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What is the main function of holins? |
Disrupt membranes |
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What is the function of lysozymes? |
Degrade cell wall |
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