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12 Cards in this Set
- Front
- Back
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describe the structure and biological properties of Retroviridae.
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enveloped
spherical (+) ssRNA diploid genome |
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True or False
Retroviridae carries 10-50 copies of reverse transcriptase. |
True
-tRNA is found in the viron |
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What type of capsids are found on Retroviridae?
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B,C,D, Lentivirinae, Spunivirine, Endogenous viruses
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what could be a potential problem in association with xenotransplants and retroviruses?
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Retroviruses from other species could integrate themselves into a human disease.
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What are the components of a Retrovirus?
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Simple Retrovirus:
gag pol env LTR 2. Complex Genomes -extra regulatory genes -tax-transactivator -rex regulation of splicing |
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Describe the HIV life cycle.
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1. Attachment & Penetration
2. Genome replication 3. Assembly and release |
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describe the attachment and penetration of HIV.
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-HIV attaches to host cell CD4 molecule
-CCR5 & CXCR4 involved -VAP is gp120/gp41 after fusion with viral envelope and host cell membrane the viral RNA carried to the nucleus |
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Describe genome replication due to a retrovirus.
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Reverse transcriptase makes DNA copy of viral genome
becomes integrated into host cell chromosomes *** LTR is promotor -- promotes RNA production and mRNA, Genomic RNA |
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how does the RNA travel from the nucleus to the cytoplasm?
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RNA exported from nucleus into cytoplasm
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Describe the assembly and release of HIV?
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RNA complex with viral proteins forming RNP capsid
-associated with the matrix protein -virus buds out through plasma membrane which acquires envelope and glycoproteins |
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Do simple retroviruses produce any disease symptoms?
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NO
oncogenic potential |
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Do complex retrovirus infect immune system cells and have the potential to be an oncogene.
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True
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