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14 Cards in this Set

  • Front
  • Back
When is the outer envelope of HIV acquired?
During virion budding
Describe the outer envelope of HIV
Studded with ~72 oligomeric spikes formed by two major viral-envelope glycoproteins (gp120 and gp 41)
Describe the HIV genome
Two identical RNA strands, RNA polymerase, integrase, and two tRNAs base-paired to the genome within the protein core
What are the principal target cells for HIV infection
CD4+ T lymphocytes and cells of the monoctye/macrophage lineage
How does HIV enter cells
Via a direct pH-independent membrane fusion event between the virion and host cell membranes
What is the primary high-affinity cell surface receptor for HIV
The CD4 glycoprotein; CCR5 and CXCR4 are essential coreceptors
What is special about people who lack CCR5
They are highly resistant to HIV infection
What is the first step of HIV infection of a cell?
Binding of the gp120 subunit to CD4 is the first required step of virus infection
Why do patients with HIV experience long clinically quiescent periods?
Failure of the host to mount a sterilizing immune response
Which cells mount the internal immune response to HIV?
HIV-specific CD8+ T Cells (CTLs) are generated and kill virus infected cells
What is the first required step of HIV infection
Binding of the gp120 subunit to CD4
The R5 HIV strains typically infect what cells
Macrophages and primary T-cells. R5 is the virus type most commonly transmitted
What are the major HIV targets of neutralizing antibodies
Glycoproteins 120 and 41
What are two common tests used for HIV
HIV Western Blot